Click here to switch to the map view.

The map label for this gene is serS

Identifier: 195952750

GI number: 195952750

Start: 327655

End: 328920

Strand: Direct

Name: serS

Synonym: HY04AAS1_0372

Alternate gene names: 195952750

Gene position: 327655-328920 (Clockwise)

Preceding gene: 195952749

Following gene: 195952751

Centisome position: 21.01

GC content: 35.23

Gene sequence:

>1266_bases
ATGATTAGTATAGAGCTTATAAGAAAAAATCCAGAGTATGTAAAAGAAAACTTAGCCAAAAGAGATATGTTTTTGAAAGA
CAGGATAGATGACATACTAAAACTAGACGAAGAAAGAAGGCATAAGATAAAAAGAATTGAGGATTTGAGGGCTCTCAGAA
ACGCTAAAAGCAAGGAGATAGGTAGTTTAAAAAAACAAGGACTAAACACGGAATCCCTTGAAGAAGAGATAAGGTTAATT
AAAGAAGAAATATCAAAGTTAGAGGAAGAGTTAGCCCGCATAGAAAAATATACAGAAGACCTTCTTCTTAGAGTACCAAA
TTTATTACACGAAAGTGTTCCTTACGGTAAGGATGAAAACGATAACGTAGAGATTAAAAGATGGGGTGAAATACCAAAGT
TTGATTTTGGAATAAAAGACCATGCTGATCTTGGTGTTTTGAGAGGTTTTATAGATTTTGACCAAGCTACCGCTATATCT
GGTAGTAGGTTTAGCATATTGAAAGGTCCTTTGGCAAAGCTAGAAAGGGCTCTTATAAACTTTATGCTTGAGATAAATGC
GAAGAATGGCTATCAGGAAATGATAGTGCCTCATCTTGTAAAACCTCAAACGTTAGTGGGCACTGGGCAGCTTCCAAAAT
TTCAAGAAGAGCTTTACTATGTAAAAGATGATGATCTTTATCTTATACCTACTGCTGAAGTACCTCTTGTAAACGTATTT
AAAGACACCATATTAAAAGAAGATGATTTGCCCATTAACCTTACAGCTTATACTCCTTGTTATAGGAGAGAGGCGGGTTC
TCATGGAAAAGATGTGAAAGGGCTTATTAGACAACACCAGTTTGATAAAGTAGAGCTTGTAAAAATAGTTCATCCAGATA
GTTCTTACGACGAGCTAGAAAGGCTTTTGTCAAATGCAGAGGAGATTTTACAACTTTTAGAACTTCCCTACAGAGTAGTG
GCTCTTTGTTCTGGTGATATAGGTTTTTCAGCTTCTAAAACTTACGATATAGAGGTATGGATACCTTCTCAAAATAAGTA
TAGAGAAATATCTTCTTGTTCTAACTGTGAAGATTTTCAAGCAAGGAGGGCAAACATGAGGTTTAAAGATAAAACTGGCA
AAAATAGGTTTGTTCACACTCTAAACGGTTCTTCTTTGGCGGTAGGTAGGACGTTGGTGGCTATTATGGAAAATTATCAA
ACGAAAGATCACAAAATTAGAATACCAAAGGTTTTAAAAGATTACATAAAGGGAGAGTGTATATGA

Upstream 100 bases:

>100_bases
AAAGCCTAATACAGCGTATAAAAGTACCTGCTGGTATAGGCGTGCCTGAGGAAAAAGTTATCGATTTAAAAGACGACAAG
ATATATAAGGTGGTATCATT

Downstream 100 bases:

>100_bases
GAAAGGCACATATTTTTAGACAGACAAAAGAAACGGCTATAGATATGGAGATTGACCTAGATGGTTCTGGTGTTTATCAA
ATAGAGACACCTGTAGGTTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MISIELIRKNPEYVKENLAKRDMFLKDRIDDILKLDEERRHKIKRIEDLRALRNAKSKEIGSLKKQGLNTESLEEEIRLI
KEEISKLEEELARIEKYTEDLLLRVPNLLHESVPYGKDENDNVEIKRWGEIPKFDFGIKDHADLGVLRGFIDFDQATAIS
GSRFSILKGPLAKLERALINFMLEINAKNGYQEMIVPHLVKPQTLVGTGQLPKFQEELYYVKDDDLYLIPTAEVPLVNVF
KDTILKEDDLPINLTAYTPCYRREAGSHGKDVKGLIRQHQFDKVELVKIVHPDSSYDELERLLSNAEEILQLLELPYRVV
ALCSGDIGFSASKTYDIEVWIPSQNKYREISSCSNCEDFQARRANMRFKDKTGKNRFVHTLNGSSLAVGRTLVAIMENYQ
TKDHKIRIPKVLKDYIKGECI

Sequences:

>Translated_421_residues
MISIELIRKNPEYVKENLAKRDMFLKDRIDDILKLDEERRHKIKRIEDLRALRNAKSKEIGSLKKQGLNTESLEEEIRLI
KEEISKLEEELARIEKYTEDLLLRVPNLLHESVPYGKDENDNVEIKRWGEIPKFDFGIKDHADLGVLRGFIDFDQATAIS
GSRFSILKGPLAKLERALINFMLEINAKNGYQEMIVPHLVKPQTLVGTGQLPKFQEELYYVKDDDLYLIPTAEVPLVNVF
KDTILKEDDLPINLTAYTPCYRREAGSHGKDVKGLIRQHQFDKVELVKIVHPDSSYDELERLLSNAEEILQLLELPYRVV
ALCSGDIGFSASKTYDIEVWIPSQNKYREISSCSNCEDFQARRANMRFKDKTGKNRFVHTLNGSSLAVGRTLVAIMENYQ
TKDHKIRIPKVLKDYIKGECI
>Mature_421_residues
MISIELIRKNPEYVKENLAKRDMFLKDRIDDILKLDEERRHKIKRIEDLRALRNAKSKEIGSLKKQGLNTESLEEEIRLI
KEEISKLEEELARIEKYTEDLLLRVPNLLHESVPYGKDENDNVEIKRWGEIPKFDFGIKDHADLGVLRGFIDFDQATAIS
GSRFSILKGPLAKLERALINFMLEINAKNGYQEMIVPHLVKPQTLVGTGQLPKFQEELYYVKDDDLYLIPTAEVPLVNVF
KDTILKEDDLPINLTAYTPCYRREAGSHGKDVKGLIRQHQFDKVELVKIVHPDSSYDELERLLSNAEEILQLLELPYRVV
ALCSGDIGFSASKTYDIEVWIPSQNKYREISSCSNCEDFQARRANMRFKDKTGKNRFVHTLNGSSLAVGRTLVAIMENYQ
TKDHKIRIPKVLKDYIKGECI

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=455, Percent_Identity=34.2857142857143, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI8923421, Length=399, Percent_Identity=32.8320802005013, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI225579074, Length=399, Percent_Identity=32.0802005012531, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=50.1170960187354, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=456, Percent_Identity=32.4561403508772, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=327, Percent_Identity=29.3577981651376, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6320226, Length=428, Percent_Identity=32.9439252336449, Blast_Score=229, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6321799, Length=426, Percent_Identity=31.4553990610329, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24581334, Length=453, Percent_Identity=32.8918322295806, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI17737985, Length=280, Percent_Identity=33.2142857142857, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HYDS0 (B4U7F1)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002121040.1
- ProteinModelPortal:   B4U7F1
- SMR:   B4U7F1
- GeneID:   6743166
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0372
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48636; Mature: 48636

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIELIRKNPEYVKENLAKRDMFLKDRIDDILKLDEERRHKIKRIEDLRALRNAKSKEI
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHH
GSLKKQGLNTESLEEEIRLIKEEISKLEEELARIEKYTEDLLLRVPNLLHESVPYGKDEN
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DNVEIKRWGEIPKFDFGIKDHADLGVLRGFIDFDQATAISGSRFSILKGPLAKLERALIN
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCHHHHHCHHHHHHHHHHH
FMLEINAKNGYQEMIVPHLVKPQTLVGTGQLPKFQEELYYVKDDDLYLIPTAEVPLVNVF
HHEEECCCCCHHHHHHHHHCCCCEEECCCCCCCHHHHEEEEECCCEEEEECCCCCHHHHH
KDTILKEDDLPINLTAYTPCYRREAGSHGKDVKGLIRQHQFDKVELVKIVHPDSSYDELE
HHHHCCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
RLLSNAEEILQLLELPYRVVALCSGDIGFSASKTYDIEVWIPSQNKYREISSCSNCEDFQ
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCHHHH
ARRANMRFKDKTGKNRFVHTLNGSSLAVGRTLVAIMENYQTKDHKIRIPKVLKDYIKGEC
HHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCC
I
C
>Mature Secondary Structure
MISIELIRKNPEYVKENLAKRDMFLKDRIDDILKLDEERRHKIKRIEDLRALRNAKSKEI
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHH
GSLKKQGLNTESLEEEIRLIKEEISKLEEELARIEKYTEDLLLRVPNLLHESVPYGKDEN
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DNVEIKRWGEIPKFDFGIKDHADLGVLRGFIDFDQATAISGSRFSILKGPLAKLERALIN
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCHHHHHCHHHHHHHHHHH
FMLEINAKNGYQEMIVPHLVKPQTLVGTGQLPKFQEELYYVKDDDLYLIPTAEVPLVNVF
HHEEECCCCCHHHHHHHHHCCCCEEECCCCCCCHHHHEEEEECCCEEEEECCCCCHHHHH
KDTILKEDDLPINLTAYTPCYRREAGSHGKDVKGLIRQHQFDKVELVKIVHPDSSYDELE
HHHHCCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
RLLSNAEEILQLLELPYRVVALCSGDIGFSASKTYDIEVWIPSQNKYREISSCSNCEDFQ
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCHHHH
ARRANMRFKDKTGKNRFVHTLNGSSLAVGRTLVAIMENYQTKDHKIRIPKVLKDYIKGEC
HHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA