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The map label for this gene is gyrA [H]

Identifier: 195952749

GI number: 195952749

Start: 325358

End: 327658

Strand: Direct

Name: gyrA [H]

Synonym: HY04AAS1_0371

Alternate gene names: 195952749

Gene position: 325358-327658 (Clockwise)

Preceding gene: 195952745

Following gene: 195952750

Centisome position: 20.86

GC content: 36.25

Gene sequence:

>2301_bases
ATGGAAATATTGGAAATCCCTATAGAAGAAGAGGCAAGACAATCTTATCTTGACTATGCGATGTCTGTTATAGTTGGTAG
GGCTATACCAGACGTTAGAGATGGCCTTAAGCCGGTTCAAAGAAGAATACTGTATGCAATGTATGAAATGGACCTAACCC
CAGATAAACCCTTTAAAAAATGTGCCCGTATCGTAGGGGATACTATGGGAAGATATCATCCCCATGGAGATCAAGCTATA
TACGATGCTCTTGTAAGAATGGCTCAGGATTTCAACCTTAGATATCCTCTTGTAATAGGACAGGGAAATTTTGGTTCTAT
AGATGGAGACCCTCCTGCTGCAATGAGATATACAGAGGCAAAGCTATCTAAGATAACCCTTAGCTTATTGGAAGATATAG
AAAACGATACTGTAGATTTTGTACCAAATTTTGATGAGAGTGTCATGGAGCCTCAGGTTCTTCCGGCAAAGATGCCAAAC
CTTCTTTGCAACGGTACTACAGGCATAGCGGTAGGGCTTGCTACTTCTATCCCCCCTCACAATCTAAAAGAAGTTTGCGA
TGCGTTGGTGGCTTTGGCTCAAAACCAAGATATAACTGTAGAAGAGCTTATGCAATATATAAAAGGACCAGATTTTCCCA
CAGGCGGTATAATAGTGGGGGAAGTATCGCCAGAGGTTTACAAAACCGGAAGAGGACAAGTTACTGTTCAAGCAAAGGCA
AGAGTAGAAAAAACAAGCTCTGGAAGAGAACAAATAATAATAACAGAAATCCCTTACATGGTCAACAAAGCAGAGCTTAT
AAAAAAGATAGCAGAACTAGCAAGGTCTGGTAAGCTAAAAGAGATTTCTGACTTAAGAGACGAATCTGACAAAGAAGGTA
TAAGAATAGTAATAGAACTAAAGAGAGATGCTAAAGGAGAGGCTGTATTAAAAAAACTTTACAAAAATACATCCCTTAGA
AAAAACTTTCCTATAAATATGGTGGCTTTGGTGGGACTTGAACCAAAGCTTTTAAATCTAAAAGATATTTTGCTGGAATT
TTTCAAACATAGGCTAAATGTGATCTATAGAAGGACTGAGTTTTTCTTAAGAAAAGCCGAAGAAAGACTTCATATAGTAG
AAGGACTTTTGATTTGTATAAAAGATATAGACAAAATTATAGAAACCATTAGAGCTTCACAAGACACCCAAGAGGCTAAA
GAAAAGCTCATGAGTGGCTGGAATCTAACTGAAAAGCAAGCTCAAGCAATACTTGATTTAAGATTACAAAGACTTACATC
CTTAGAAACTTCTAAGCTTCAAAAAGAACACGATGAGCTTATAGAAAATATCAAGACTTATAAAAATATATTGGAAAACA
AACAAGAAAGGATAAACATCTTTATAAAAGAGACAAAAGAACTTGCAGATCGTTTCAAAGACCCAAGAAGAACTTTCATC
GAAGGTATGATAAAAGAAGATACCTATGTGGATGTTTTTGTCACGAGAAATGGATTTGTAAAACCTATAGAGCTTTTAGA
AGAGGAAAAATCTCCTATTGTTAATGTGGCAAGTTTGAAGTTTACAGAAGGCCTTTTCATAGTATCAAATAAAGGAAGAG
TTTATTGGACTGCTGGGTCAGAAGCTTTGTCTGGAAGCTCCATTCATATGAAGGATACCGACGAGCACGTTGTAGGTGCC
TTTGTGAGAGAGCAATACAACTCAAGACTTCTTATCTTGACAAATAAAGGCTCTATAAAGAAGATACCTCTTGTGGAGTT
TGAATACAAAACCCAAGGCTTTCAAATATTGAAGCTCTCAGAAGGTGAAGAGGTGGTTTATATAAGCGGTTCTCAAGATG
AGAGCGAAATACTTATTTTAACCAAGAAAGGTTATATAAATAGAATTCAAACCCAGGATGTAGGAGCAACCACATCTAGC
TCAAAAGCCATTCAATGTATAAAGCTTAATGAAAATGATGAGGCTATCTCGGTGAGAGCTTTAGATGACAAGATTTTTGG
GCTTTTGATAACAGAAGAAGGATACGCTAAAAAGATAAAGCTAGAGGATATTCCAAAAAAATCTAGAACATCTCAAGGTA
TAAACGTATTAAAGCAAAAGTTTTTAAACGCTTGCGATTTGATATTTTACAACGATGACGATAATTTTGATGTGTTGATA
TCCACTTTTAACGGCTCTCATATAAAATTTGATATTAAAAGCCTAATACAGCGTATAAAAGTACCTGCTGGTATAGGCGT
GCCTGAGGAAAAAGTTATCGATTTAAAAGACGACAAGATATATAAGGTGGTATCATTATGA

Upstream 100 bases:

>100_bases
ACCCTATAACTGGCTCAAATTCCATAGCCATTACATTATAGCATAAAGCTTTATTAAAGTTTAATTGGTTTTATGCTTTT
AGTATGATAAAATTTTAATT

Downstream 100 bases:

>100_bases
TTAGTATAGAGCTTATAAGAAAAAATCCAGAGTATGTAAAAGAAAACTTAGCCAAAAGAGATATGTTTTTGAAAGACAGG
ATAGATGACATACTAAAACT

Product: DNA topoisomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 766

Protein sequence:

>766_residues
MEILEIPIEEEARQSYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMYEMDLTPDKPFKKCARIVGDTMGRYHPHGDQAI
YDALVRMAQDFNLRYPLVIGQGNFGSIDGDPPAAMRYTEAKLSKITLSLLEDIENDTVDFVPNFDESVMEPQVLPAKMPN
LLCNGTTGIAVGLATSIPPHNLKEVCDALVALAQNQDITVEELMQYIKGPDFPTGGIIVGEVSPEVYKTGRGQVTVQAKA
RVEKTSSGREQIIITEIPYMVNKAELIKKIAELARSGKLKEISDLRDESDKEGIRIVIELKRDAKGEAVLKKLYKNTSLR
KNFPINMVALVGLEPKLLNLKDILLEFFKHRLNVIYRRTEFFLRKAEERLHIVEGLLICIKDIDKIIETIRASQDTQEAK
EKLMSGWNLTEKQAQAILDLRLQRLTSLETSKLQKEHDELIENIKTYKNILENKQERINIFIKETKELADRFKDPRRTFI
EGMIKEDTYVDVFVTRNGFVKPIELLEEEKSPIVNVASLKFTEGLFIVSNKGRVYWTAGSEALSGSSIHMKDTDEHVVGA
FVREQYNSRLLILTNKGSIKKIPLVEFEYKTQGFQILKLSEGEEVVYISGSQDESEILILTKKGYINRIQTQDVGATTSS
SKAIQCIKLNENDEAISVRALDDKIFGLLITEEGYAKKIKLEDIPKKSRTSQGINVLKQKFLNACDLIFYNDDDNFDVLI
STFNGSHIKFDIKSLIQRIKVPAGIGVPEEKVIDLKDDKIYKVVSL

Sequences:

>Translated_766_residues
MEILEIPIEEEARQSYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMYEMDLTPDKPFKKCARIVGDTMGRYHPHGDQAI
YDALVRMAQDFNLRYPLVIGQGNFGSIDGDPPAAMRYTEAKLSKITLSLLEDIENDTVDFVPNFDESVMEPQVLPAKMPN
LLCNGTTGIAVGLATSIPPHNLKEVCDALVALAQNQDITVEELMQYIKGPDFPTGGIIVGEVSPEVYKTGRGQVTVQAKA
RVEKTSSGREQIIITEIPYMVNKAELIKKIAELARSGKLKEISDLRDESDKEGIRIVIELKRDAKGEAVLKKLYKNTSLR
KNFPINMVALVGLEPKLLNLKDILLEFFKHRLNVIYRRTEFFLRKAEERLHIVEGLLICIKDIDKIIETIRASQDTQEAK
EKLMSGWNLTEKQAQAILDLRLQRLTSLETSKLQKEHDELIENIKTYKNILENKQERINIFIKETKELADRFKDPRRTFI
EGMIKEDTYVDVFVTRNGFVKPIELLEEEKSPIVNVASLKFTEGLFIVSNKGRVYWTAGSEALSGSSIHMKDTDEHVVGA
FVREQYNSRLLILTNKGSIKKIPLVEFEYKTQGFQILKLSEGEEVVYISGSQDESEILILTKKGYINRIQTQDVGATTSS
SKAIQCIKLNENDEAISVRALDDKIFGLLITEEGYAKKIKLEDIPKKSRTSQGINVLKQKFLNACDLIFYNDDDNFDVLI
STFNGSHIKFDIKSLIQRIKVPAGIGVPEEKVIDLKDDKIYKVVSL
>Mature_766_residues
MEILEIPIEEEARQSYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMYEMDLTPDKPFKKCARIVGDTMGRYHPHGDQAI
YDALVRMAQDFNLRYPLVIGQGNFGSIDGDPPAAMRYTEAKLSKITLSLLEDIENDTVDFVPNFDESVMEPQVLPAKMPN
LLCNGTTGIAVGLATSIPPHNLKEVCDALVALAQNQDITVEELMQYIKGPDFPTGGIIVGEVSPEVYKTGRGQVTVQAKA
RVEKTSSGREQIIITEIPYMVNKAELIKKIAELARSGKLKEISDLRDESDKEGIRIVIELKRDAKGEAVLKKLYKNTSLR
KNFPINMVALVGLEPKLLNLKDILLEFFKHRLNVIYRRTEFFLRKAEERLHIVEGLLICIKDIDKIIETIRASQDTQEAK
EKLMSGWNLTEKQAQAILDLRLQRLTSLETSKLQKEHDELIENIKTYKNILENKQERINIFIKETKELADRFKDPRRTFI
EGMIKEDTYVDVFVTRNGFVKPIELLEEEKSPIVNVASLKFTEGLFIVSNKGRVYWTAGSEALSGSSIHMKDTDEHVVGA
FVREQYNSRLLILTNKGSIKKIPLVEFEYKTQGFQILKLSEGEEVVYISGSQDESEILILTKKGYINRIQTQDVGATTSS
SKAIQCIKLNENDEAISVRALDDKIFGLLITEEGYAKKIKLEDIPKKSRTSQGINVLKQKFLNACDLIFYNDDDNFDVLI
STFNGSHIKFDIKSLIQRIKVPAGIGVPEEKVIDLKDDKIYKVVSL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=359, Percent_Identity=25.9052924791086, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19913406, Length=353, Percent_Identity=26.0623229461756, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1788562, Length=807, Percent_Identity=41.1400247831475, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1789396, Length=697, Percent_Identity=36.5853658536585, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=469, Percent_Identity=25.5863539445629, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=32.9341317365269, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=164, Percent_Identity=31.0975609756098, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI115534553, Length=161, Percent_Identity=29.8136645962733, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=398, Percent_Identity=27.6381909547739, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136538, Length=359, Percent_Identity=24.7910863509749, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 86757; Mature: 86757

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILEIPIEEEARQSYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMYEMDLTPDKPFKK
CCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
CARIVGDTMGRYHPHGDQAIYDALVRMAQDFNLRYPLVIGQGNFGSIDGDPPAAMRYTEA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHH
KLSKITLSLLEDIENDTVDFVPNFDESVMEPQVLPAKMPNLLCNGTTGIAVGLATSIPPH
HHHHHHHHHHHHCCCCCEECCCCCCHHHCCCCCCCHHCCCCEECCCCCEEEEEECCCCCC
NLKEVCDALVALAQNQDITVEELMQYIKGPDFPTGGIIVGEVSPEVYKTGRGQVTVQAKA
CHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCEEEEEEEH
RVEKTSSGREQIIITEIPYMVNKAELIKKIAELARSGKLKEISDLRDESDKEGIRIVIEL
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEE
KRDAKGEAVLKKLYKNTSLRKNFPINMVALVGLEPKLLNLKDILLEFFKHRLNVIYRRTE
CCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FFLRKAEERLHIVEGLLICIKDIDKIIETIRASQDTQEAKEKLMSGWNLTEKQAQAILDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
RLQRLTSLETSKLQKEHDELIENIKTYKNILENKQERINIFIKETKELADRFKDPRRTFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHHHCCCHHHHHH
EGMIKEDTYVDVFVTRNGFVKPIELLEEEKSPIVNVASLKFTEGLFIVSNKGRVYWTAGS
HHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCEEEEEEEEECCEEEEECCCEEEEECCC
EALSGSSIHMKDTDEHVVGAFVREQYNSRLLILTNKGSIKKIPLVEFEYKTQGFQILKLS
CCCCCCEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCEEECCEEEEEECCCCEEEEEEC
EGEEVVYISGSQDESEILILTKKGYINRIQTQDVGATTSSSKAIQCIKLNENDEAISVRA
CCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEE
LDDKIFGLLITEEGYAKKIKLEDIPKKSRTSQGINVLKQKFLNACDLIFYNDDDNFDVLI
ECCCEEEEEEECCCCCEEEECCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEE
STFNGSHIKFDIKSLIQRIKVPAGIGVPEEKVIDLKDDKIYKVVSL
EECCCCEEEEHHHHHHHHHCCCCCCCCCHHHEEECCCCCEEEEECC
>Mature Secondary Structure
MEILEIPIEEEARQSYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMYEMDLTPDKPFKK
CCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
CARIVGDTMGRYHPHGDQAIYDALVRMAQDFNLRYPLVIGQGNFGSIDGDPPAAMRYTEA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHH
KLSKITLSLLEDIENDTVDFVPNFDESVMEPQVLPAKMPNLLCNGTTGIAVGLATSIPPH
HHHHHHHHHHHHCCCCCEECCCCCCHHHCCCCCCCHHCCCCEECCCCCEEEEEECCCCCC
NLKEVCDALVALAQNQDITVEELMQYIKGPDFPTGGIIVGEVSPEVYKTGRGQVTVQAKA
CHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCEEEEEEEH
RVEKTSSGREQIIITEIPYMVNKAELIKKIAELARSGKLKEISDLRDESDKEGIRIVIEL
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEE
KRDAKGEAVLKKLYKNTSLRKNFPINMVALVGLEPKLLNLKDILLEFFKHRLNVIYRRTE
CCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FFLRKAEERLHIVEGLLICIKDIDKIIETIRASQDTQEAKEKLMSGWNLTEKQAQAILDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
RLQRLTSLETSKLQKEHDELIENIKTYKNILENKQERINIFIKETKELADRFKDPRRTFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHHHCCCHHHHHH
EGMIKEDTYVDVFVTRNGFVKPIELLEEEKSPIVNVASLKFTEGLFIVSNKGRVYWTAGS
HHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCEEEEEEEEECCEEEEECCCEEEEECCC
EALSGSSIHMKDTDEHVVGAFVREQYNSRLLILTNKGSIKKIPLVEFEYKTQGFQILKLS
CCCCCCEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCEEECCEEEEEECCCCEEEEEEC
EGEEVVYISGSQDESEILILTKKGYINRIQTQDVGATTSSSKAIQCIKLNENDEAISVRA
CCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEE
LDDKIFGLLITEEGYAKKIKLEDIPKKSRTSQGINVLKQKFLNACDLIFYNDDDNFDVLI
ECCCEEEEEEECCCCCEEEECCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEE
STFNGSHIKFDIKSLIQRIKVPAGIGVPEEKVIDLKDDKIYKVVSL
EECCCCEEEEHHHHHHHHHCCCCCCCCCHHHEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]