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The map label for this gene is sumT [H]

Identifier: 195952721

GI number: 195952721

Start: 302467

End: 303213

Strand: Direct

Name: sumT [H]

Synonym: HY04AAS1_0343

Alternate gene names: 195952721

Gene position: 302467-303213 (Clockwise)

Preceding gene: 195952720

Following gene: 195952722

Centisome position: 19.39

GC content: 37.35

Gene sequence:

>747_bases
ATGGGTAAAGTATATTTAGTGGGTGCTGGTCCCGGTGATCCTGAGCTACTTACTCTAAAAGCAATAAAAGCCCTTGAGCG
ATCTGATGTTGTGTTGTATGACAAGCTTGTAAACAAAGATATACTATCTTATGCGAAAAAAGAGGCAATAAAAATATGCG
TTGGAAAAGAAAGAGGATTTCATTCTATAGAACAAGATAATATAAACGATCTTATCTTGGAATACGCACATTTAGGATAC
GATGTAACAAGGCTTAAAAGCGGCGATCCTTTTGTATTTGGAAGAGGTGGAGAGGAGGCTTTGTTTCTTAAAAATCATGG
TGTAGAGTTTGAGGTGATACCTGGAGTCACATCTGCCGTTGGTTTACCTACTCATGCGTATATCCCTATTACCTACAGAG
GGATATCATCTTCCTTCGCTGTTATAACGGGACATAAAGAAAATGGTAGTCTAAAGCATATAAATTGGGATAAGATAGTT
GGCGTAGATACGCTTGTTTTTTTAATGGCTGTCTCTTCAAGACAGGAGATAGCAAAGCACCTTATAGATGCAGGAAGAGA
TCCGAATGAGCCAGTTGCGTTTGTAGAAAATGGTTTTAGTCAAAACGAAAAAATAATAATAACCAATTTAAAAGACTTAC
TACACAACAATATAGAAGTAAATACCCCTGCTGTGATGATAGTAGGTCAGGTGGTAAACATGAGAGATAAATTAAGATCC
ATGGAGGTGGCTTTATGCAAGTGTTAA

Upstream 100 bases:

>100_bases
GTAAAAATCCTTGATACTTCAGATTTTAAAATAATAAAAGAGATAACCGTACCTCAACCCTCAGGTATCTTCAGATTACC
AGAAAGACTGGAGGAGTGTC

Downstream 100 bases:

>100_bases
AACAAAAATTAATTGATGTAATCCAGCAAGATATACCCATACAAGAAAACCCTTTTCAGTGGATAGCCGAACAGCTTAAT
ACGGATTTAGACAATGTTTT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MGKVYLVGAGPGDPELLTLKAIKALERSDVVLYDKLVNKDILSYAKKEAIKICVGKERGFHSIEQDNINDLILEYAHLGY
DVTRLKSGDPFVFGRGGEEALFLKNHGVEFEVIPGVTSAVGLPTHAYIPITYRGISSSFAVITGHKENGSLKHINWDKIV
GVDTLVFLMAVSSRQEIAKHLIDAGRDPNEPVAFVENGFSQNEKIIITNLKDLLHNNIEVNTPAVMIVGQVVNMRDKLRS
MEVALCKC

Sequences:

>Translated_248_residues
MGKVYLVGAGPGDPELLTLKAIKALERSDVVLYDKLVNKDILSYAKKEAIKICVGKERGFHSIEQDNINDLILEYAHLGY
DVTRLKSGDPFVFGRGGEEALFLKNHGVEFEVIPGVTSAVGLPTHAYIPITYRGISSSFAVITGHKENGSLKHINWDKIV
GVDTLVFLMAVSSRQEIAKHLIDAGRDPNEPVAFVENGFSQNEKIIITNLKDLLHNNIEVNTPAVMIVGQVVNMRDKLRS
MEVALCKC
>Mature_247_residues
GKVYLVGAGPGDPELLTLKAIKALERSDVVLYDKLVNKDILSYAKKEAIKICVGKERGFHSIEQDNINDLILEYAHLGYD
VTRLKSGDPFVFGRGGEEALFLKNHGVEFEVIPGVTSAVGLPTHAYIPITYRGISSSFAVITGHKENGSLKHINWDKIVG
VDTLVFLMAVSSRQEIAKHLIDAGRDPNEPVAFVENGFSQNEKIIITNLKDLLHNNIEVNTPAVMIVGQVVNMRDKLRSM
EVALCKC

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=238, Percent_Identity=42.436974789916, Blast_Score=204, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6322922, Length=235, Percent_Identity=35.3191489361702, Blast_Score=128, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27313; Mature: 27182

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLVGAGPGDPELLTLKAIKALERSDVVLYDKLVNKDILSYAKKEAIKICVGKERGF
CCEEEEEECCCCCCCEEEHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHEEEEECCCCCC
HSIEQDNINDLILEYAHLGYDVTRLKSGDPFVFGRGGEEALFLKNHGVEFEVIPGVTSAV
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEECCCCEEEEEECCCCEEEECCCCHHHH
GLPTHAYIPITYRGISSSFAVITGHKENGSLKHINWDKIVGVDTLVFLMAVSSRQEIAKH
CCCCEEEEEEEEECCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHH
LIDAGRDPNEPVAFVENGFSQNEKIIITNLKDLLHNNIEVNTPAVMIVGQVVNMRDKLRS
HHHCCCCCCCCEEEEECCCCCCCEEEEEEHHHHHCCCCEECCCEEEEEHHHHHHHHHHHH
MEVALCKC
HHHHEECC
>Mature Secondary Structure 
GKVYLVGAGPGDPELLTLKAIKALERSDVVLYDKLVNKDILSYAKKEAIKICVGKERGF
CEEEEEECCCCCCCEEEHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHEEEEECCCCCC
HSIEQDNINDLILEYAHLGYDVTRLKSGDPFVFGRGGEEALFLKNHGVEFEVIPGVTSAV
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEECCCCEEEEEECCCCEEEECCCCHHHH
GLPTHAYIPITYRGISSSFAVITGHKENGSLKHINWDKIVGVDTLVFLMAVSSRQEIAKH
CCCCEEEEEEEEECCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHH
LIDAGRDPNEPVAFVENGFSQNEKIIITNLKDLLHNNIEVNTPAVMIVGQVVNMRDKLRS
HHHCCCCCCCCEEEEECCCCCCCEEEEEEHHHHHCCCCEECCCEEEEEHHHHHHHHHHHH
MEVALCKC
HHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]