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The map label for this gene is dxr [H]

Identifier: 195952475

GI number: 195952475

Start: 87770

End: 88906

Strand: Direct

Name: dxr [H]

Synonym: HY04AAS1_0095

Alternate gene names: 195952475

Gene position: 87770-88906 (Clockwise)

Preceding gene: 195952474

Following gene: 195952476

Centisome position: 5.63

GC content: 35.97

Gene sequence:

>1137_bases
ATGACAAGGCTTGGTGTACTTGGTTCTACGGGGACTATTGGGAAAAATGCCCTTGATATTGTTAGATCAAACAAAGATAA
GATAGAGCTTATAGGTATAGGTGCATATCGATCATCCAAAGGGCTTTTAGAAGAGGTTAAAGAGTTTAGACCTAAGTTTG
TTTTTAGTGTAGAAACCCCTACAAAAGACTGGATTGATGAGGTTTCAAAATATTCTACATACCTTAACGAAGAAGAGGGA
CTTCAGGCTATTATAGAAAACTCCGATAGGATTTTAAACGCTATATCTGGGACCTCTGGCATAAAAGCCACTTACAGCAT
ACTAAAAGCTAAAAAAATACTTCTTGCTTCCAACAAGGAATCAATCCTTTGTATGCCAAACCTAATAAGAGAAAATATTG
AGCTAGTGATACCGGTAGACAGCGAACACAATGCCGCTTTTGAGCTTCTTAAAAGCCACAAAACTGTGAAAAACCTTTAT
ATAACAGCTTCAGGTGGTCCTTTCAGAGGGTATTCCAAAGAACAGCTAAAAACTGTAAGCAAAGAAGAGGCTCTTAAACA
CCCAAATTGGAAGATGGGTCCAAAGATAACCATAGACTCTGCAACACTTATGAACAAAGGATTTGAACTTGTAGAAGCCA
GTGTATTGTTTAATATACCACTTGAACGCATAAAGATATTGATACATCCTCAAAGTATAGTGCATGCCATAGTTGAACTT
GAAAACGGCTCTTTTATAGCAAATATGTCGCTTCCAGATATGAGGCTTCCTATTCAAAACGCTATTTTTTATCCAGAGAT
GGTAAATTATACCTTCAATAGGTTAGATTTAACATCTATTTCTTGTCTTACTTTTGAAAAGCCTAAAAGGGATTTGTTTA
GGGCTATCGATGTTTGTGAATGGGTAGCCTCTATGGGAAACCCTTATGTATCTGTGCTTTTAGGAGCTGATGATAAAGCT
GTAGAGCTTTTTTTAGAAGGGAAAATTGGATTTCTTGATATACCAGTTTTGATAGAGAGCGTACTTTCTTCGGTGAATTT
TCATATAGAAGAGAATCTTGAAGATATTTTAAGGGCTGTGGAGTTTGGTAAAAACAAATTACTAGAATTATCAAATCATA
GGCTAACTAACTGTTAA

Upstream 100 bases:

>100_bases
AACATACAGATTATCACGCATTCCTTCGTTTACACGCTTTTAGTATGGTATTAAATCTTATACAAATGATAAATAGCTTT
TTTATAATACTAAGTTTGAT

Downstream 100 bases:

>100_bases
AACTTTCCTTCTTTTTTCTACTATTTTGTGCTTGAAAAAATTAGAATTTATACTATATTTAAAGTATGTATAAGATAAGA
AAATTTTCTAAGCTTACAGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTRLGVLGSTGTIGKNALDIVRSNKDKIELIGIGAYRSSKGLLEEVKEFRPKFVFSVETPTKDWIDEVSKYSTYLNEEEG
LQAIIENSDRILNAISGTSGIKATYSILKAKKILLASNKESILCMPNLIRENIELVIPVDSEHNAAFELLKSHKTVKNLY
ITASGGPFRGYSKEQLKTVSKEEALKHPNWKMGPKITIDSATLMNKGFELVEASVLFNIPLERIKILIHPQSIVHAIVEL
ENGSFIANMSLPDMRLPIQNAIFYPEMVNYTFNRLDLTSISCLTFEKPKRDLFRAIDVCEWVASMGNPYVSVLLGADDKA
VELFLEGKIGFLDIPVLIESVLSSVNFHIEENLEDILRAVEFGKNKLLELSNHRLTNC

Sequences:

>Translated_378_residues
MTRLGVLGSTGTIGKNALDIVRSNKDKIELIGIGAYRSSKGLLEEVKEFRPKFVFSVETPTKDWIDEVSKYSTYLNEEEG
LQAIIENSDRILNAISGTSGIKATYSILKAKKILLASNKESILCMPNLIRENIELVIPVDSEHNAAFELLKSHKTVKNLY
ITASGGPFRGYSKEQLKTVSKEEALKHPNWKMGPKITIDSATLMNKGFELVEASVLFNIPLERIKILIHPQSIVHAIVEL
ENGSFIANMSLPDMRLPIQNAIFYPEMVNYTFNRLDLTSISCLTFEKPKRDLFRAIDVCEWVASMGNPYVSVLLGADDKA
VELFLEGKIGFLDIPVLIESVLSSVNFHIEENLEDILRAVEFGKNKLLELSNHRLTNC
>Mature_377_residues
TRLGVLGSTGTIGKNALDIVRSNKDKIELIGIGAYRSSKGLLEEVKEFRPKFVFSVETPTKDWIDEVSKYSTYLNEEEGL
QAIIENSDRILNAISGTSGIKATYSILKAKKILLASNKESILCMPNLIRENIELVIPVDSEHNAAFELLKSHKTVKNLYI
TASGGPFRGYSKEQLKTVSKEEALKHPNWKMGPKITIDSATLMNKGFELVEASVLFNIPLERIKILIHPQSIVHAIVELE
NGSFIANMSLPDMRLPIQNAIFYPEMVNYTFNRLDLTSISCLTFEKPKRDLFRAIDVCEWVASMGNPYVSVLLGADDKAV
ELFLEGKIGFLDIPVLIESVLSSVNFHIEENLEDILRAVEFGKNKLLELSNHRLTNC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=31.9095477386935, Blast_Score=226, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42333; Mature: 42201

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLGVLGSTGTIGKNALDIVRSNKDKIELIGIGAYRSSKGLLEEVKEFRPKFVFSVETP
CCCEECCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCC
TKDWIDEVSKYSTYLNEEEGLQAIIENSDRILNAISGTSGIKATYSILKAKKILLASNKE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCC
SILCMPNLIRENIELVIPVDSEHNAAFELLKSHKTVKNLYITASGGPFRGYSKEQLKTVS
CEEECCHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHH
KEEALKHPNWKMGPKITIDSATLMNKGFELVEASVLFNIPLERIKILIHPQSIVHAIVEL
HHHHHCCCCCCCCCEEEECCHHHHHCCHHHHEEHHHCCCCHHHEEEEECCHHHHHHHHEE
ENGSFIANMSLPDMRLPIQNAIFYPEMVNYTFNRLDLTSISCLTFEKPKRDLFRAIDVCE
CCCCEEEECCCCCCCCCHHHHCCCHHHHCCCCCCEEECEEEEEECCCCHHHHHHHHHHHH
WVASMGNPYVSVLLGADDKAVELFLEGKIGFLDIPVLIESVLSSVNFHIEENLEDILRAV
HHHHHCCCEEEEEECCCCCEEEEEEECCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHH
EFGKNKLLELSNHRLTNC
HHCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TRLGVLGSTGTIGKNALDIVRSNKDKIELIGIGAYRSSKGLLEEVKEFRPKFVFSVETP
CCEECCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCC
TKDWIDEVSKYSTYLNEEEGLQAIIENSDRILNAISGTSGIKATYSILKAKKILLASNKE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCC
SILCMPNLIRENIELVIPVDSEHNAAFELLKSHKTVKNLYITASGGPFRGYSKEQLKTVS
CEEECCHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHH
KEEALKHPNWKMGPKITIDSATLMNKGFELVEASVLFNIPLERIKILIHPQSIVHAIVEL
HHHHHCCCCCCCCCEEEECCHHHHHCCHHHHEEHHHCCCCHHHEEEEECCHHHHHHHHEE
ENGSFIANMSLPDMRLPIQNAIFYPEMVNYTFNRLDLTSISCLTFEKPKRDLFRAIDVCE
CCCCEEEECCCCCCCCCHHHHCCCHHHHCCCCCCEEECEEEEEECCCCHHHHHHHHHHHH
WVASMGNPYVSVLLGADDKAVELFLEGKIGFLDIPVLIESVLSSVNFHIEENLEDILRAV
HHHHHCCCEEEEEECCCCCEEEEEEECCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHH
EFGKNKLLELSNHRLTNC
HHCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]