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The map label for this gene is hisC [H]

Identifier: 194738143

GI number: 194738143

Start: 2171195

End: 2172274

Strand: Direct

Name: hisC [H]

Synonym: SeSA_A2301

Alternate gene names: 194738143

Gene position: 2171195-2172274 (Clockwise)

Preceding gene: 194734077

Following gene: 194737825

Centisome position: 46.11

GC content: 55.56

Gene sequence:

>1080_bases
ATGAGCACTGAAAACACTCTCAGCGTCGCTGACTTAGCCCGTGAAAATGTCCGCAACCTGGTACCGTATCAGTCCGCCCG
CCGTCTGGGCGGTAACGGCGATGTCTGGCTGAACGCGAATGAATTCCCGACAGCGGTGGAGTTTCAGCTCACCCAACAAA
CGCTTAACCGCTACCCGGAATGCCAGCCAAAGGCCGTGATTGAAAACTACGCGCAATATGCTGGCGTAAAGCCGGAGCAG
GTGCTGGTCAGCCGCGGCGCGGATGAAGGGATCGAGCTGGTGATCCGCGCCTTCTGTGAACCGGGGAAAGACGCCATTCT
CTACTGTCCGCCCACTTACGGTATGTACAGCGTCAGCGCCGAAACCATTGGTGTAGAGCGCCGGACGGTTCCCGCGCTTG
AAAACTGGCAGCTGGATCTACAGGGGATTTCCGACAACCTTGACGGCACAAAAGTGGTGTTCGTTTGTAGCCCCAATAAT
CCTACCGGGCAACTTATCAACCCGCAGGATCTGCGCACGCTGCTGGAGTTGACACGCGGTAAAGCGATAGTCGTCGCCGA
CGAAGCTTATATTGAGTTTTGCCCACAGGCCACGCTGACAGGCTGGCTGGTTGAATATCCTCATCTGGTTATCCTGCGCA
CATTGTCGAAAGCTTTTGCGCTGGCTGGTCTGCGCTGCGGCTTTACTCTGGCTAATGAAGAGGTGATCAACCTGCTGTTA
AAAGTGATCGCCCCTTATCCGCTTTCTACGCCAGTGGCGGATATCGCCGCCCAGGCGCTGAGCCCGCAGGGAATAAACGC
AATGCGCGATCGCGTGGCGCAGACAGTGCAGGAACGTCAGTATCTGGTGAATGCCCTGCAACAGACCGCCTGCGTAGAAC
ACGTCTTTGACTCTGAAACCAACTATATTCTGGCGCGATTTACTGCCTCCAGCAGCGTGTTTAAATCCTTATGGGATCAG
GGCATTATCTTACGCGATCAGAATAAACAACCTTCTTTAAGCGGCTGCCTGCGGATTACGGTCGGCACCCGCCAGGAAAA
CCAGCGCGTCATTGACGCCTTACGTGCGGAGCCAGTATGA

Upstream 100 bases:

>100_bases
CCGCTCTGGCATCAACCATTGAAACATTGGCGGCGGCAGAACGTCTGACCGCCCATAAAAATGCCGTGACCCTGCGCGTA
AACGCCCTCAAGGAGCAAGC

Downstream 100 bases:

>100_bases
GTCAGAAGTATCTTTTCATTGACCGGGACGGTACCTTAATTTCCGAACCGCCGAGCGATTTTCAGGTAGACCGCTTTGAT
AAACTGGCCTTTGAGCCAGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSTENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQ
VLVSRGADEGIELVIRAFCEPGKDAILYCPPTYGMYSVSAETIGVERRTVPALENWQLDLQGISDNLDGTKVVFVCSPNN
PTGQLINPQDLRTLLELTRGKAIVVADEAYIEFCPQATLTGWLVEYPHLVILRTLSKAFALAGLRCGFTLANEEVINLLL
KVIAPYPLSTPVADIAAQALSPQGINAMRDRVAQTVQERQYLVNALQQTACVEHVFDSETNYILARFTASSSVFKSLWDQ
GIILRDQNKQPSLSGCLRITVGTRQENQRVIDALRAEPV

Sequences:

>Translated_359_residues
MSTENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQ
VLVSRGADEGIELVIRAFCEPGKDAILYCPPTYGMYSVSAETIGVERRTVPALENWQLDLQGISDNLDGTKVVFVCSPNN
PTGQLINPQDLRTLLELTRGKAIVVADEAYIEFCPQATLTGWLVEYPHLVILRTLSKAFALAGLRCGFTLANEEVINLLL
KVIAPYPLSTPVADIAAQALSPQGINAMRDRVAQTVQERQYLVNALQQTACVEHVFDSETNYILARFTASSSVFKSLWDQ
GIILRDQNKQPSLSGCLRITVGTRQENQRVIDALRAEPV
>Mature_358_residues
STENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQV
LVSRGADEGIELVIRAFCEPGKDAILYCPPTYGMYSVSAETIGVERRTVPALENWQLDLQGISDNLDGTKVVFVCSPNNP
TGQLINPQDLRTLLELTRGKAIVVADEAYIEFCPQATLTGWLVEYPHLVILRTLSKAFALAGLRCGFTLANEEVINLLLK
VIAPYPLSTPVADIAAQALSPQGINAMRDRVAQTVQERQYLVNALQQTACVEHVFDSETNYILARFTASSSVFKSLWDQG
IILRDQNKQPSLSGCLRITVGTRQENQRVIDALRAEPV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=89.2957746478873, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1788722, Length=228, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=376, Percent_Identity=33.7765957446808, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39700; Mature: 39568

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPTAVEFQLTQQTLNRYPE
CCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCCEEEEEEHHHHHHCCCC
CQPKAVIENYAQYAGVKPEQVLVSRGADEGIELVIRAFCEPGKDAILYCPPTYGMYSVSA
CCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEECH
ETIGVERRTVPALENWQLDLQGISDNLDGTKVVFVCSPNNPTGQLINPQDLRTLLELTRG
HHCCCCCCCCCCHHCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCC
KAIVVADEAYIEFCPQATLTGWLVEYPHLVILRTLSKAFALAGLRCGFTLANEEVINLLL
CEEEEECHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHH
KVIAPYPLSTPVADIAAQALSPQGINAMRDRVAQTVQERQYLVNALQQTACVEHVFDSET
HHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NYILARFTASSSVFKSLWDQGIILRDQNKQPSLSGCLRITVGTRQENQRVIDALRAEPV
CEEEEEECCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
STENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPTAVEFQLTQQTLNRYPE
CCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCCEEEEEEHHHHHHCCCC
CQPKAVIENYAQYAGVKPEQVLVSRGADEGIELVIRAFCEPGKDAILYCPPTYGMYSVSA
CCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEECH
ETIGVERRTVPALENWQLDLQGISDNLDGTKVVFVCSPNNPTGQLINPQDLRTLLELTRG
HHCCCCCCCCCCHHCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCC
KAIVVADEAYIEFCPQATLTGWLVEYPHLVILRTLSKAFALAGLRCGFTLANEEVINLLL
CEEEEECHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHH
KVIAPYPLSTPVADIAAQALSPQGINAMRDRVAQTVQERQYLVNALQQTACVEHVFDSET
HHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NYILARFTASSSVFKSLWDQGIILRDQNKQPSLSGCLRITVGTRQENQRVIDALRAEPV
CEEEEEECCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA