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The map label for this gene is hisB [H]

Identifier: 194737825

GI number: 194737825

Start: 2172271

End: 2173338

Strand: Direct

Name: hisB [H]

Synonym: SeSA_A2302

Alternate gene names: 194737825

Gene position: 2172271-2173338 (Clockwise)

Preceding gene: 194738143

Following gene: 194738319

Centisome position: 46.13

GC content: 52.15

Gene sequence:

>1068_bases
ATGAGTCAGAAGTATCTTTTCATTGACCGGGACGGTACCTTAATTTCCGAACCGCCGAGCGATTTTCAGGTAGACCGCTT
TGATAAACTGGCCTTTGAGCCAGAGGTGATTCCCGTATTGCTGAAGCTGCAAAAAGCCGGTTTTAAGCTGGTGATGATCA
CTAACCAGGATGGACTTGGCACGCAAAGCTTCCCGCAGGCGGACTTCGACGGACCGCACAACCTGATGATGCAGATTTTC
ACCTCTCAGGGCGTACGCTTTGATGAGGTGCTGATCTGCCCTCACCTGCCCGCAGACGATTGCGAGTGCCGCAAGCCCAA
AGTGAAGCTGGTGGAGCGTTATCTTGCGGAACAAGCGATGGATAGCGCCAACAGCTATGTGATTGGCGATCGTGCAACCG
ATATCCAGCTCGCTGATAACATGGGCATTACTGGTTTACGCTATCACCGTGAAACGCTGAACTGGACGATGATTGGCGAA
CAGCTAACGAAACGCGATCGCTATGCGCATGTGGTCCGCAACACCAAAGAGACACAGATTGATGTCAGCGTCTGGCTGGA
TCGCGAAGGCAACAGCAAGATTAATACCGGCGTCGGCTTCTTTGACCATATGCTCGATCAAATCGCCACCCACGGCGGCT
TTCGCATGGAGATTACCGTTAAGGGCGATCTCTATATCGACGATCACCACACGGTAGAAGATACCGGACTGGCGCTCGGT
GAAGCATTAAAACTGGCACTCGGCGACAAGCGCGGTATCTGCCGTTTTGGCTTTGTACTGCCGATGGATGAATGTCTGGC
GCGCTGCGCGCTGGATATTTCCGGTCGTCCGCATCTGGAATATAAAGCTGAATTTACCTACCAGCGTGTGGGCGATTTGA
GCACAGAGATGATTGAACACTTTTTCCGCTCACTCTCTTACACGATGGGCGTCACTCTGCATCTCAAGACTAAGGGTAAG
AACGATCACCACCGTGTCGAAAGTTTGTTTAAAGCCTTTGGTCGAACGCTACGCCAGGCTATTCGCGTGGAGGGCGATAC
ATTACCGTCCTCGAAAGGAGTGCTGTGA

Upstream 100 bases:

>100_bases
ATCAGAATAAACAACCTTCTTTAAGCGGCTGCCTGCGGATTACGGTCGGCACCCGCCAGGAAAACCAGCGCGTCATTGAC
GCCTTACGTGCGGAGCCAGT

Downstream 100 bases:

>100_bases
TGAACGTCGTCATCCTTGACACCGGCTGCGCCAATTTAAGCTCGGTAAAATCCGCCGTGGCGCGCCACGGTTACACCCCG
GTGGTCAGCCGCGAAGCGGA

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPEVIPVLLKLQKAGFKLVMITNQDGLGTQSFPQADFDGPHNLMMQIF
TSQGVRFDEVLICPHLPADDCECRKPKVKLVERYLAEQAMDSANSYVIGDRATDIQLADNMGITGLRYHRETLNWTMIGE
QLTKRDRYAHVVRNTKETQIDVSVWLDREGNSKINTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALG
EALKLALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVTLHLKTKGK
NDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL

Sequences:

>Translated_355_residues
MSQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPEVIPVLLKLQKAGFKLVMITNQDGLGTQSFPQADFDGPHNLMMQIF
TSQGVRFDEVLICPHLPADDCECRKPKVKLVERYLAEQAMDSANSYVIGDRATDIQLADNMGITGLRYHRETLNWTMIGE
QLTKRDRYAHVVRNTKETQIDVSVWLDREGNSKINTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALG
EALKLALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVTLHLKTKGK
NDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
>Mature_354_residues
SQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPEVIPVLLKLQKAGFKLVMITNQDGLGTQSFPQADFDGPHNLMMQIFT
SQGVRFDEVLICPHLPADDCECRKPKVKLVERYLAEQAMDSANSYVIGDRATDIQLADNMGITGLRYHRETLNWTMIGEQ
LTKRDRYAHVVRNTKETQIDVSVWLDREGNSKINTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALGE
ALKLALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEHFFRSLSYTMGVTLHLKTKGKN
DHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=95.7746478873239, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI1786399, Length=146, Percent_Identity=32.1917808219178, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324776, Length=166, Percent_Identity=47.5903614457831, Blast_Score=159, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 40251; Mature: 40119

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPEVIPVLLKLQKAGFKLVMITNQDGLG
CCCCEEEEECCCCEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCEEEEEEECCCCCC
TQSFPQADFDGPHNLMMQIFTSQGVRFDEVLICPHLPADDCECRKPKVKLVERYLAEQAM
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
DSANSYVIGDRATDIQLADNMGITGLRYHRETLNWTMIGEQLTKRDRYAHVVRNTKETQI
HCCCCEEECCCCCEEEEECCCCCCEEEEHHHHCCEEEECHHHHHHHHHHHHHCCCCCCEE
DVSVWLDREGNSKINTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALG
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECEEEECCCCCCHHHHHHHH
EALKLALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEH
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHCCHHHHHHHH
FFRSLSYTMGVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
HHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPEVIPVLLKLQKAGFKLVMITNQDGLG
CCCEEEEECCCCEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCEEEEEEECCCCCC
TQSFPQADFDGPHNLMMQIFTSQGVRFDEVLICPHLPADDCECRKPKVKLVERYLAEQAM
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
DSANSYVIGDRATDIQLADNMGITGLRYHRETLNWTMIGEQLTKRDRYAHVVRNTKETQI
HCCCCEEECCCCCEEEEECCCCCCEEEEHHHHCCEEEECHHHHHHHHHHHHHCCCCCCEE
DVSVWLDREGNSKINTGVGFFDHMLDQIATHGGFRMEITVKGDLYIDDHHTVEDTGLALG
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECEEEECCCCCCHHHHHHHH
EALKLALGDKRGICRFGFVLPMDECLARCALDISGRPHLEYKAEFTYQRVGDLSTEMIEH
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHCCHHHHHHHH
FFRSLSYTMGVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRVEGDTLPSSKGVL
HHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]