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The map label for this gene is nanT1 [H]

Identifier: 194737981

GI number: 194737981

Start: 3405645

End: 3407135

Strand: Reverse

Name: nanT1 [H]

Synonym: SeSA_A3531

Alternate gene names: 194737981

Gene position: 3407135-3405645 (Counterclockwise)

Preceding gene: 194737314

Following gene: 194734915

Centisome position: 72.35

GC content: 55.33

Gene sequence:

>1491_bases
ATGAGTACTTCTACCCAGAACATCCCGTGGTATCGCCATCTCAACCGGGCGCAGTGGCGGGCATTTTCCGCTGCCTGGCT
GGGATATCTGCTTGATGGTTTTGATTTTGTGTTGATTGCTCTTGTACTGACTGAGGTACAAAGCGAATTTGGGCTGACGA
CAGTACAGGCGGCAAGCCTGATTTCTGCGGCTTTTATCTCTCGCTGGTTCGGCGGGTTATTACTGGGCGCGATGGGCGAT
CGCTATGGGCGTCGTCTGGCGATGGTCAGCAGCATCATCCTGTTTTCAGTGGGAACCCTGGCCTGCGGGTTTGCGCCCGG
TTACACCACCATGTTCATCGCCCGACTGGTGATTGGTATGGGCATGGCGGGCGAATATGGTTCCAGCGCGACCTATGTGA
TTGAAAGCTGGCCAAAACATTTACGCAATAAAGCCAGCGGTTTTCTGATTTCCGGCTTCTCCGTCGGCGCGGTCGTTGCC
GCGCAGGTGTACAGCCTGGTGGTGCCTGTCTGGGGCTGGCGCGCGCTGTTTTTCATTGGCATTTTGCCAATTATCTTCGC
CCTCTGGCTGCGGAAAAACATTCCGGAAGCGGAAGACTGGAAAGAGAAACACGCGGGTAAAGCGCCGGTACGTACGATGG
TCGACATTCTTTATCGGGGCGAACATCGCATCATCAACATTTTAATGACTTTCGCCGCCGCCGCTGCGCTGTGGTTCTGT
TTTGCCGGTAACCTACAAAATGCTGCGATTGTGGCGGGGCTGGGACTACTGTGCGCGGTTATCTTTATCAGCTTTATGGT
GCAGAGCAGCGGTAAACGCTGGCCCACTGGCGTCATGCTGATGCTGGTGGTACTGTTTGCTTTCCTCTATTCCTGGCCGA
TTCAGGCGCTATTACCTACTTATCTGAAAACCGAGCTGGCCTACGATCCGCATACGGTGGCGAATGTCCTGTTCTTTAGC
GGATTTGGCGCGGCGGTTGGTTGCTGCGTAGGCGGTTTTCTTGGCGACTGGCTGGGAACGCGTAAAGCCTATGTCTGTAG
CCTGCTGGCCTCGCAAATCCTCATTATTCCGGTCTTTGCGATTGGCGGCACAAACGTCTGGGTTCTGGGTCTGCTACTGT
TTTTCCAACAGATGTTGGGGCAGGGGATTGCCGGGATTCTGCCGAAACTGATCGGCGGTTACTTCGATACCGATCAGCGC
GCGGCGGGGCTGGGCTTTACTTATAACGTCGGCGCGCTCGGCGGCGCGCTGGCGCCGATCCTGGGAGCGCTGATCGCTCA
ACGTCTGGATCTGGGCACTGCGCTAGCATCGCTCTCTTTCAGCCTGACGTTTGTCGTGATCCTGCTTATTGGGCTTGATA
TGCCGTCTCGCGTACAGCGTTGGCTACGTCCGGAAGCGTTACGTACCCACGATGCTATCGACGACAAACCGTTCAGCGGA
GCCGTACCGCTTGGCAGTGGTAAAGGTGCCTTTGTAAAAACGAAAAATTAA

Upstream 100 bases:

>100_bases
GGCGCTACGCTTGCCCGGCCTACAACAGTGTGAGCGGTAGGCCGGATAAGGCGGAGCCGCCATTCGGCATAACGACAACA
AAAATCGTCGGGAGAGTAAA

Downstream 100 bases:

>100_bases
TCCGCTTGCCCGGTTTTCAACCGGGCAATATTTGTAAGGGAGTAGTATGTCGTTACTTGAACAACTGGATAAAAATATTG
CCGCTTCTGGCGGCCTGATT

Product: putative sialic acid transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: Sialic acid permease 1 [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGD
RYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVA
AQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFC
FAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFS
GFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQR
AAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSG
AVPLGSGKGAFVKTKN

Sequences:

>Translated_496_residues
MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGD
RYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVA
AQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFC
FAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFS
GFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQR
AAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSG
AVPLGSGKGAFVKTKN
>Mature_495_residues
STSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGDR
YGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAA
QVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFCF
AGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFSG
FGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRA
AGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSGA
VPLGSGKGAFVKTKN

Specific function: May be a sugar-cation symporter involved in sialic acid uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Sialic acid transporter (TC 2.A.1.12.1) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082231, Length=496, Percent_Identity=94.5564516129032, Blast_Score=946, Evalue=0.0,
Organism=Escherichia coli, GI87082404, Length=452, Percent_Identity=35.1769911504425, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1790550, Length=470, Percent_Identity=23.8297872340426, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788292, Length=227, Percent_Identity=25.1101321585903, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788942, Length=296, Percent_Identity=27.3648648648649, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081723, Length=407, Percent_Identity=23.8329238329238, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789941, Length=488, Percent_Identity=24.3852459016393, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=188, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=207, Percent_Identity=26.0869565217391, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322632, Length=432, Percent_Identity=21.7592592592593, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004742
- InterPro:   IPR005828 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 53657; Mature: 53526

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCEEECCC
>Mature Secondary Structure 
STSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ISAAFISRWFGGLLLGAMGDRYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIG
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFC
HHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
YLKTELAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFA
HHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPI
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHCCCCCEEEHHHHHHHHHHH
LGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHCCCCCCCCCC
AVPLGSGKGAFVKTKN
CCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]