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The map label for this gene is nanA [H]

Identifier: 194737314

GI number: 194737314

Start: 3407251

End: 3408144

Strand: Reverse

Name: nanA [H]

Synonym: SeSA_A3532

Alternate gene names: 194737314

Gene position: 3408144-3407251 (Counterclockwise)

Preceding gene: 194734653

Following gene: 194737981

Centisome position: 72.37

GC content: 53.91

Gene sequence:

>894_bases
ATGGCAAAAGCATTGCAAGGCGTAATGGCGGCGTTGTTGACCCCATTTGATCATCAGCAGCAACTGGATAGCGAAAGCCT
GCGCCGTCTGGTGCGTTTTAACATCGGGCAGGGTATCGACGGGCTGTACGTTGGCGGTTCCACCGGGGAAGCATTCGTAC
AGAGCCTTGCTGAAAGAGAGCAGGTACTGGAGATTGTCGCCGAAGAGGCGAAGGGAAAAATCACGTTGATCGCCCATGTC
GGGACGGTAAGCACCGCAGAAAGCCAGCAGCTTGCCAGCGCCGCAAAGCGTTACGGTTTTGATGCGGTCTCTGCGGTGAC
GCCTTTTTATTACCCTTTCAGTTTTGAAGAGCACTGTGACCATTATCGGGCAATCATTGATTCCGCAGATGGATTGCCGA
TGGTGGTATACAACATTCCGGCGTTAAGCGGCGTAAAACTTACCCTCGATCAGATCAATACGCTGGTGACATTACCGGGC
GTGAGCGCGCTGAAGCAAACCTCCGGCGATCTCTTCCAGATGGAGCAGATCCGCCGCGCACATCCGGATCTGGTGCTGTA
CAACGGTTATGACGAAATCTTCGCTTCCGGTCTGCTGGCGGGCGCGGACGGCGGTATCGGCAGCACATACAACATTATGG
GCTGGCGTTATCAGGGGATTGTGCAGGCATTACGTGAGGGCGATGTGGCGAAAGCGCAGCGTCTGCAAACCGAGTGCAAT
AAGGTTATTGATTTACTGATTAAAACCGGCGTATTCCGCGGCCTGAAAACGGTCCTGCATTATATGGACGTGGTATCGGT
GCCGCTGTGTCGTAAACCGTTCGCGCCTGTTGATGAAAAATACCTGCCGGCGCTCAAGGCGCTGGCTCAACAACTAATGG
AAGAAAAGGCGTAA

Upstream 100 bases:

>100_bases
ATCGCACTATAAGCGTTCTGTATTATTTGCTGCTTATTTGATCTGGTATAACAGGTATAAAGGTAGGTAGTTAATATATT
CATCATCCGTAGAGGTAGGT

Downstream 100 bases:

>100_bases
CAGCATAATGCCGGGGGCGCTACGCTTGCCCGGCCTACAACAGTGTGAGCGGTAGGCCGGATAAGGCGGAGCCGCCATTC
GGCATAACGACAACAAAAAT

Product: N-acetylneuraminate lyase

Products: NA

Alternate protein names: N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHV
GTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPG
VSALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECN
KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA

Sequences:

>Translated_297_residues
MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHV
GTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPG
VSALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECN
KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
>Mature_296_residues
AKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHVG
TVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGV
SALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECNK
VIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA

Specific function: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate [H]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family. NanA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=275, Percent_Identity=30.5454545454545, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI31543060, Length=289, Percent_Identity=25.6055363321799, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1789620, Length=297, Percent_Identity=90.5723905723906, Blast_Score=559, Evalue=1e-161,
Organism=Escherichia coli, GI87082415, Length=241, Percent_Identity=29.4605809128631, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=26.2237762237762, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786463, Length=231, Percent_Identity=27.7056277056277, Blast_Score=98, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- InterPro:   IPR005264 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.1.3.3 [H]

Molecular weight: Translated: 32456; Mature: 32325

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAERE
CHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHH
QVLEIVAEEAKGKITLIAHVGTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCD
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHH
HYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVSALKQTSGDLFQMEQIRRA
HHHHHHHCCCCCEEEEEECCCCCCCEEEHHHHHHHEECCCHHHHHHCCCHHHHHHHHHHC
HPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECN
CCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAERE
HHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHH
QVLEIVAEEAKGKITLIAHVGTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCD
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHH
HYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVSALKQTSGDLFQMEQIRRA
HHHHHHHCCCCCEEEEEECCCCCCCEEEHHHHHHHEECCCHHHHHHCCCHHHHHHHHHHC
HPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECN
CCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA