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The map label for this gene is lldP [H]

Identifier: 194737852

GI number: 194737852

Start: 3765338

End: 3766993

Strand: Direct

Name: lldP [H]

Synonym: SeSA_A3893

Alternate gene names: 194737852

Gene position: 3765338-3766993 (Clockwise)

Preceding gene: 194734122

Following gene: 194735151

Centisome position: 79.96

GC content: 57.31

Gene sequence:

>1656_bases
ATGAACCTCTGGCAACAAAACTATGACCCGGCGGGTAATATCTGGCTTTCCAGCCTGATCGCATCGCTCCCAATCCTGTT
CTTCTTTTTCGCCCTGATTAAACTCAAGCTGAAAGGCTACGTTGCCGCTTCGTGGACGGTGGTTATCGCGCTCGCCGTCG
CGCTGCTGTTCTATAAAATGCCGGTCGATCACGCGCTGGCATCGGTCGTGTATGGCTTCTTCTACGGGCTATGGCCGATT
GCCTGGATAATCATCGCCGCGGTCTTCGTCTATAAAATCTCGGTAAAGACCGGGCAGTTTGACATTATCCGCTCGTCAAT
TCTGTCGATAACCCCCGATCAACGCCTGCAAATGCTGATTGTCGGCTTCTGCTTCGGCGCGTTCCTTGAAGGTGCGGCGG
GTTTCGGCGCGCCGGTGGCGATAACCGCCGCGCTGCTGGTGGGTCTGGGCTTTAATCCGCTGTATGCGGCAGGGCTGTGC
CTGATTGTAAACACCGCGCCAGTCGCCTTTGGCGCGATGGGTATTCCGATTCTGGTTGCCGGACAGGTTACGGGCCTGGA
CAGCTTTGAAATCGGTCAGATGGTAGGCCGCCAGTTGCCATTCCTGACCATTATCGTGCTGTTCTGGATTATGGCGATTA
TGGACGGCTGGCGCGGCGTGAAAGAAACCTGGCCTGCGGTGATGGTCTCTGGCGGTTCATTTGCTATCGCCCAGTATCTC
AGCTCCAACTTTATCGGGCCGGAACTGCCGGACATTATCTCTTCTCTGGTGTCTCTGGTGTGTCTGACGCTGTTCCTCAA
ACGTTGGCAGCCGGTACGCATCTTCCGCTTCGGCGATATGGGCGCGTCGCAGGTCGATCAGACGCTGGCCCGTACCCGCT
ATACGACAGGACAAATTGTTCGCGCCTGGTCGCCGTTCCTGTTCCTGACCGCCACGGTCACTCTCTGGAGCATACCGCCG
TTCAAAGCGCTGTTTGCCCCCGGCGGCGCGCTGTATGACTGGGTAATTAACGTTCCGGTACCGTATCTCGATAAACTGGT
CGCCCGTATGCCGCCAGTCGTACACGAAGCGACCGCTTACGCGGCGGTGTATAAATTTGACTGGTTCTCCGCCACCGGCA
CAGCGATCCTGTTTGCCGCGCTGTTGTCTATCGTCTGGCTGAAAATGAAACCCTCAGCCGCAATCCAGACCTTCGGCAGC
ACGCTGAAAGAGCTGGCGTTGCCGATTTACTCCATCGGCATGGTGCTGGCGTTCGCGTTTATCTCGAACTATTCCGGGCT
TTCCTCCACGCTGGCGTTAGCGCTGGCGCACACCGGCAGCGCCTTCACGTTCTTCTCGCCGTTCCTCGGCTGGCTGGGGG
TATTCCTGACCGGCTCGGATACCTCATCTAACGCGCTGTTTGCCTCTCTACAGGCTACCGCGGCGCAGCAAATCGGCGTT
TCGGATGTGCTGATGGTGGCGGCAAATACCACCGGCGGCGTGACCGGCAAGATGATCTCGCCGCAATCTATCGCCATCGC
CTGCGCGGCGGTGGGGCTAGTAGGGAAAGAGTCCGATCTGTTCCGTTTTACCGTCAAACACAGCCTGATCTTCACCTGTA
TGGTGGGCGTGATCACTACGCTTCAGGCCTATGTTTTAACCTGGATGATTCCGTGA

Upstream 100 bases:

>100_bases
ACACAACAATATTGGCAGGACCACTTTTACACATAATGTGACCCCAACGAGATGAGCAAAGATTCATCCCATTATGCGTG
TGGTTCTCAGGAGACCTGCA

Downstream 100 bases:

>100_bases
TTGTGATGCCAAAACGCCTGTCTGACGAGATTGCCTCTCGCGTGCGGGCGCTGATTGAAGAACAAAACCTGGAAGCGGGC
ATGAAATTGCCCGCCGAGCG

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVVIALAVALLFYKMPVDHALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVSGGSFAIAQYL
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDMGASQVDQTLARTRYTTGQIVRAWSPFLFLTATVTLWSIPP
FKALFAPGGALYDWVINVPVPYLDKLVARMPPVVHEATAYAAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFASLQATAAQQIGV
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Sequences:

>Translated_551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVVIALAVALLFYKMPVDHALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVSGGSFAIAQYL
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDMGASQVDQTLARTRYTTGQIVRAWSPFLFLTATVTLWSIPP
FKALFAPGGALYDWVINVPVPYLDKLVARMPPVVHEATAYAAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFASLQATAAQQIGV
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP
>Mature_551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVVIALAVALLFYKMPVDHALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVSGGSFAIAQYL
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDMGASQVDQTLARTRYTTGQIVRAWSPFLFLTATVTLWSIPP
FKALFAPGGALYDWVINVPVPYLDKLVARMPPVVHEATAYAAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFASLQATAAQQIGV
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=94.3738656987296, Blast_Score=1013, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=63.6200716845878, Blast_Score=695, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59448; Mature: 59448

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVVIALAVALLFYKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVDHALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHH
VGFCFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCHHHEEECCCHHHCCCCCCEEEE
GQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVSGGSFAIAQYL
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCHHHHHHH
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDMGASQVDQTLARTRYTTGQIV
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHH
RAWSPFLFLTATVTLWSIPPFKALFAPGGALYDWVINVPVPYLDKLVARMPPVVHEATAY
HHHCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHH
AAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGSTLKELALPIYSIGMVLAFAF
HHHEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFASLQATAAQQIGV
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCH
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITT
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHH
LQAYVLTWMIP
HHHHHHHHCCC
>Mature Secondary Structure
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVVIALAVALLFYKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVDHALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHH
VGFCFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCHHHEEECCCHHHCCCCCCEEEE
GQVTGLDSFEIGQMVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVMVSGGSFAIAQYL
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCHHHHHHH
SSNFIGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDMGASQVDQTLARTRYTTGQIV
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHH
RAWSPFLFLTATVTLWSIPPFKALFAPGGALYDWVINVPVPYLDKLVARMPPVVHEATAY
HHHCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHH
AAVYKFDWFSATGTAILFAALLSIVWLKMKPSAAIQTFGSTLKELALPIYSIGMVLAFAF
HHHEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNYSGLSSTLALALAHTGSAFTFFSPFLGWLGVFLTGSDTSSNALFASLQATAAQQIGV
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCH
SDVLMVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITT
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHH
LQAYVLTWMIP
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]