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The map label for this gene is hemE [H]

Identifier: 194737614

GI number: 194737614

Start: 4250147

End: 4251211

Strand: Direct

Name: hemE [H]

Synonym: SeSA_A4378

Alternate gene names: 194737614

Gene position: 4250147-4251211 (Clockwise)

Preceding gene: 194735127

Following gene: 194735033

Centisome position: 90.25

GC content: 57.65

Gene sequence:

>1065_bases
ATGACCGAACTCAAAAACGATCGTTATCTACGTGCGCTGCTGCGCCAGCCCGTTGATGTTACGCCAGTGTGGATGATGCG
CCAGGCGGGCCGTTATCTACCGGAGTACAAAGCCACTCGCGCTCAGGCGGGCGATTTTATGTCGCTGTGCAAAAATGCCG
AACTGGCCTGCGAGGTCACTTTACAGCCGCTGCGCCGTTATCCGCTTGATGCGGCGATCCTTTTCTCGGATATCCTGACG
ATTCCGGACGCGATGGGCCTGGGGCTCTATTTTGAAGCCGGGGAAGGCCCGCGCTTTACGGCTCCTGTCACCTGCAAAGC
CGATGTCGATAAGCTGCCCATTCCCGCTCCGGAAGATGAACTGGGTTATGTGATGAATGCGGTGCGTACGATTCGCCGCG
AACTAAAAGGCGAGGTTCCGCTGATTGGCTTTTCCGGCAGCCCGTGGACGCTGGCGACTTACATGGTGGAAGGCGGCAGT
AGCAAAGCCTTCACGGTGATTAAAAAGATGATGTACGCTGACCCGCAGGCGTTGCATCTGCTGCTGGATAAGTTGGCGAA
AAGCGTCACGCTGTACCTCAACGCGCAAATCAAAGCGGGCGCGCAGTCGGTGATGATTTTCGACACCTGGGGCGGCGTGC
TGACTGGCCGCGATTACCAGCAGTTCTCCCTCTACTACATGCATAAAATCGTCGATGGCCTGCTGCGTGAAAACGACGGT
CGCCGTGTGCCGGTAACGCTGTTCACTAAAGGTGGCGGTCAGTGGCTGGAGGCGATGGCGGAAACCGGCTGCGACGCGCT
GGGTCTCGACTGGACGACAGATATCGCCGATGCGCGCCGTCGCGTTGGCCATAAAGTGGCGCTGCAGGGCAATATGGACC
CCTCGATGCTGTATGCGCCGCCGGCACGGATCGAAGACGAGGTAGCGACTATACTTGCTGGTTTCGGTCAGGGAGAAGGG
CACGTCTTTAATCTTGGACATGGCATCCATCAGGATGTGCCGCCAGAACATGCTGGCGCATTTGTGGAGGCAGTGCACCG
ACTTTCTGCGCAGTATCACAACTAA

Upstream 100 bases:

>100_bases
ACCGTCGCGCGCCGTTTGATCGAAGATACGGTGGCAATGTGTCGGGCTGAATATGATTGACATGTTACACTGGGCGCATC
AACGCTAAAGGAATGTAAAA

Downstream 100 bases:

>100_bases
GGAGTTAGTATGGATCTCGCGTCGCTACGCGCTCAACAGATAGAACTTGCTTCATCGGTTTGCCGCGAAGATCGGTTGGA
CAAAGATCCGCCAGCGTTTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLYFEAGEGPRFTAPVTCKADVDKLPIPAPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEG
HVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN

Sequences:

>Translated_354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLYFEAGEGPRFTAPVTCKADVDKLPIPAPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEG
HVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN
>Mature_353_residues
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTI
PDAMGLGLYFEAGEGPRFTAPVTCKADVDKLPIPAPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGR
RVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEGH
VFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=47.8632478632479, Blast_Score=312, Evalue=2e-85,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=97.1671388101983, Blast_Score=713, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=37.9213483146067, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.6512968299712, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.6512968299712, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39133; Mature: 39001

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTAPVTCKADVDKLPIPAPEDE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCEEECCCCCCCCCCCCCHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
HHHHHHHHEEEEEEEEEECCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEDEVATILAGFGQGEGHVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTAPVTCKADVDKLPIPAPEDE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCEEECCCCCCCCCCCCCHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
HHHHHHHHEEEEEEEEEECCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEDEVATILAGFGQGEGHVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA