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The map label for this gene is aaeB [H]

Identifier: 194737497

GI number: 194737497

Start: 3428202

End: 3430169

Strand: Reverse

Name: aaeB [H]

Synonym: SeSA_A3556

Alternate gene names: 194737497

Gene position: 3430169-3428202 (Counterclockwise)

Preceding gene: 194734710

Following gene: 194737005

Centisome position: 72.84

GC content: 52.95

Gene sequence:

>1968_bases
ATGGGCATTTTCTCCATTGCCAACCAGCACATTCGTTTTGCGGTAAAGCTGGCGTGCGCCATTGTGCTGGCATTATTTAT
CGGCTTCCATTTTCAACTGGAGACGCCGCGTTGGGCGGTGCTGACCGCCGCGATCGTGGCGGCAGGCCCGGCATTTGCCG
CCGGCGGGGAACCCTATTCCGGCGCTATCCGTTATCGCGGAATGTTGCGTATTATCGGGACGTTTATTGGCTGTATCGCC
GCGCTTATCATTATTATCTCTATGATCCGCGCGCCGCTATTGATGATTTTGGTGTGCTGTGTCTGGGCCGGTTTTTGTAC
CTGGATCTCCTCTTTAGTACGGATCGAAAACTCTTATGCGTGGGGACTGTCAGGTTATACTGCGCTGATCATTGTGATTA
CCATTCAGACGGAGCCGCTGCTCACGCCGCAATTTGCGCTTGAACGCTGTAGCGAAATCGTCATCGGCATTGGCTGCGCT
ATTTTAGCGGATCTGCTTTTCTCGCCGCGATCGATAAAGCAGGAGGTTGATCGCGAACTGGACAGTTTACTGGTAGCGCA
ATATCAGCTAATGCAACTTTGTATTAAGCATGGCGACAGCGAAGAAGTCGACAACGCCTGGGGCGATCTGGTGCGACGCA
CGGCGGCGCTGGAGGGGATGCGAAGTAATCTGAATATGGAATCTTCGCGCTGGGTACGCGCTAACCGCCGCCTGAAAGCG
TTGAATACGCTTTCGCTCACGCTGATTACGCAATCCTGTGAAACTTATCTTATTCAAAACACGCGGCCGGAACTGATTAC
CGATACATTCCGGGAACTGTTCGAGACGCCGGTTGAAACGGTACAGGACGTCCACAGACAGTTAAAACGGATGCGGCGTG
TCATTGTCTGGACCGGCGAGCGCGAAACGCCCGTCACGCTTTATAGCTGGGTAGGCGCTGCGACGCGCTATCTGCTGCTT
AAACGCGGCGTGATCAGCAACACCAAAATCAGCGCGACGGAAGAAGAGATCCTGCAAGGCGAGCCCGTAGTTAAAGTGGA
ATCCGCTGAACGCCACCATGCGATGGTGAACTTCTGGCGCACCACGCTTTCCTGCATTCTGGGGACATTATTCTGGCTAT
GGACCGGCTGGACATCGGGTAATGGCGCGATGGTGATGATTGCCGTGGTGACCTCGCTGGCGATGCGTTTACCCAATCCG
CGCATGGTCTGCATTGATTTTATTTATGGCACTCTGGCGGCGTTGCCGCTGGGATTGCTCTATTTCCTGGTGATTATTCC
CAATACGCAGCAAAGTATGCTGTTGTTATGTTTGAGCCTGGCGGTATTGGGGTTCTTTATCGGCATTGAGGTCCAGAAAC
GGCGTCTGGGGTCGATGGGGGCGCTGGCCAGTACGATTAACATTATTGTGTTGGATAATCCGATGACGTTCCATTTCAGC
CAGTTCCTCGACAGCGCGTTGGGGCAAATTGTTGGCTGTATGCTGGCGTTTATCGTCATCCTGCTGGTGCGTGATAAATC
CAAAGATCGAACCGGTCGCGTGCTGCTTAATCAGTTTGTTTCCGCTGCGGTCTCGGCAATGACGACCAACGTGGTACGTC
GTAAAGAAAACCGTCTGCCTGCGTTATATCAGCAACTCTTTTTGCTGATGAATAAATTCCCTGGCGATTTGCCGAAGTTT
CGCCTGGCGCTAACGATGATCATTGCTCATCAACGCCTGCGCGACGCGCCGATACCGGTTAATGAAGATCTGTCAGTGTT
TCACCGTCAGCTTCGTCGTACCGCAGACCATGTTATTTCCGCCGGAAGCGATGATAAACGGCGACGCTACTTTGGTCAGT
TGCTGGATGAGCTGGATATCTATCAGGAGAAATTACGTATCTGGGAGGCGCCGCCGCAGGTGACGGAACCGGTTAAACGC
CTGACGGGCATGTTACATAAATACCAGAACGCGCTTACCGATAGCTAA

Upstream 100 bases:

>100_bases
CGGCAACCGTCGTGATCACCGGTAAGCAGGATCGTGACGCAAGCCAGGACTCCTTCTTCCGTAAACTGGCGCACCGGCTG
CGCGAATTCGGTTAATCGTC

Downstream 100 bases:

>100_bases
CCCACAAGAACCGATGCCAAAAGCGTCGGTTTTTTTATGACTATACTTATTTGAGATACAAAAACAGCGCAAGAGTGCTC
CGGGGCTAAAAGCGTTTCTG

Product: p-hydroxybenzoic acid efflux subunit AaeB

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIA
ALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCA
ILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKA
LNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLL
KRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNP
RMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFS
QFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKF
RLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKR
LTGMLHKYQNALTDS

Sequences:

>Translated_655_residues
MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIA
ALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCA
ILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKA
LNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLL
KRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNP
RMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFS
QFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKF
RLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKR
LTGMLHKYQNALTDS
>Mature_654_residues
GIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAA
LIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAI
LADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKAL
NTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLK
RGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPR
MVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQ
FLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFR
LALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRL
TGMLHKYQNALTDS

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=655, Percent_Identity=92.3664122137405, Blast_Score=1234, Evalue=0.0,
Organism=Escherichia coli, GI1787933, Length=516, Percent_Identity=22.8682170542636, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 73647; Mature: 73516

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
GAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDREL
CCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
RETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHH
TTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEEEECCCCHHHHH
QFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVIS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
AGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
GAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDREL
CCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
RETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHH
TTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEEEECCCCHHHHH
QFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVIS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
AGSDDKRRRYFGQLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA