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The map label for this gene is bisC [H]

Identifier: 194737074

GI number: 194737074

Start: 3708301

End: 3710634

Strand: Reverse

Name: bisC [H]

Synonym: SeSA_A3839

Alternate gene names: 194737074

Gene position: 3710634-3708301 (Counterclockwise)

Preceding gene: 194735354

Following gene: 194736179

Centisome position: 78.8

GC content: 57.67

Gene sequence:

>2334_bases
TTGACCCACGTACCATCGCGTCATTCGGTATTGACCGCCGCACACTGGGGGCCAGTCCGCGTTGAAACCGACGGAGAACG
CATTTTTGCCTCGTATGGCGAACTCCCGACGGCACACCAAAACTCCCTGCAAACCGTTGTGCATGACCAGGTTCACAGTA
AAACGCGGGTTCGCTTCCCGATGGTGCGTAAAGGGTTCCTGGCTTCTCCCGATAAGCCGCAAGGCATACGCGGGCAGGAT
GAGTTTGTTCGCGTAAGTTGGGATGACGCGCTGGATCTGATCCACGCTCAGCACAAACGTATTCGCGAAAGTTATGGACC
ATCGTCCATCTTCGCCGGCTCCTACGGTTGGCGTTCGAACGGCGTATTGCATAAAGCGGCTACGCTATTGCAGCGTTACA
TGGCGCTGGCGGGAGGGTATACCGGCCATCTTGGCGATTATTCCACCGGCGCGGCGCAGGCTATCATGCCTTATGTAGTG
GGTGGCAACGAGGTTTACCAGCAGCAGACTAGCTGGCCGGTGGTGCTGGAACACAGCGAGGTGGTGGTGCTCTGGAGCGC
GAACCCGCTGAATACTCTGAAAATTGCCTGGAACGCCTCGGATGAACAGGGGCTCGACTATTTTGCGGCGTTGCGACAAA
GCGGCAAGCGCCTGATCTGCATCGATCCGATGCGATCGGAAAGCGTCGACTTTTTTGGCGATAAGATGGAGTGGATCGCC
CCGCATATGGGCACCGATGTGGCGTTAATGTTGGGGATCGCCCATACGCTGGTGGAAAACGATTGGCAGGATGAAGCGTT
CCTTGCCCGCTGCACGACGGGTTATGACCGTTTCGCCGACTATCTTTTGGGCAAGACCGACGGTACGGCCAAAACAGCGG
AATGGGCGGCGGAAATTTGCGGCGTTTCTGCGGTGAAAATTCGTGAACTGGCGGAAATATTTCATCATAACACCACCATG
TTGATGGCCGGTTGGGGAATGCAGCGTCAGCAGTTCGGCGAGCAAAAGCACTGGATGATCGTCACGCTGGCCGCAATGCT
GGGGCAAATTGGTACGCCTGGCGGCGGGTTTGGTTTTTCTTATCATTTTGCTAACGGCGGAAACCCGACGCGCCGCGCCG
CCGTGTTAGCCTCGATGCAGGGAAGCATCCCTGGCGGGGTCGATGCGGTAGATAAAATACCGGTGGCGCGTATTGTCGAG
GCGCTGGAAAACCCCGGTGGGTTTTACCAACACAATGGGATGGATCGCCGCTTCCCGGATATTCGTTTTATCTGGTGGGC
GGGCGGCGCGAACTTTACCCATCATCAGGATACCAACCGTCTGATTCGCGCGTGGCAAAAACCGGAACTGGTCGTTATCT
CAGAATGTTTCTGGACGGCCGCCGCGAAACACGCGGATATTGTTCTGCCTGCGACCACCAGCTATGAGCGTAACGATTTA
ACCATGACCGGCGACTATAGCAATCAGCATTTGGCGCCGATGAAGCAGGTCGTGTCGCCCCGGTGGGAGGCGCGGAATGA
TTTTGACGTTTTTGCTGAACTGAGCGAACGGTGGGAAGCCGGCGGTTACGCTCGGTTCACCGAAGGAAAAAGTGAGCTGG
CGTGGCTGGAGACTTTCTACAATATTGCCGCCCAGCGTGGCGCCAGCCAGGGGGTGACGCTGCCGCCGTTTGCCGCATTC
TGGCAGGCTAACCGTTTACTGGAGATGCCGGAAAATCCCGCCAACGCGCAGTTTGTGCGCTTCGCGGATTTTCGCCGCGA
TCCTGATAACCATCCGCTAAAAACGGCCAGCGGCAAAATCGAAATCTATTCTGCGCGCATTGCCAGCTATGGTTACGCGG
ATTGTCCCGGCCATCCGATGTGGCTGGTGCCGGATGAGTGGCACGGGAACGCTGATGCGGGGCAGGTTCAGCTACTTTCC
GCGCATCCGGCGCACCGTCTGCATAGCCAGCTTAACTACAGTTCGTTACGGGAGCGGTATGCGGTAGCCGGACGCGAACC
GGTGACGATTCATCCGCAGGATGCGACAACGCGTGGAATCGTCGATGGCGATACGGTACGCGTCTGGAATCATCGCGGGC
AGGTTCTGGCGGGCGCGGTCGTTACCGACGGAATTCGGCCTGGCGTGATCTGTATTCACGAAGGCGCATGGCCGGACCCT
GAACCTACCGCAGGCGGCATATGCAAAAACGGCGCGGTAAACGTCCTGACAAAAGATCTTCCCAGTTCCCGGCTGGGGAA
CGGTTGTGCGGGCAACACCGCGCTGGTCTGGTTTGAGAAATATACCGGCCCGGCGCTACCGCTTACGGCGTTTGATCCGC
CTGCCAACTCATAA

Upstream 100 bases:

>100_bases
TATGACGTCTGCACATGAAGAAAATTCCAGGGAAAACTCTGAAATTTGTAAGTAACATTGATCGGCAAAATAAATAATCC
CAATAATTCAGGAGCGAACC

Downstream 100 bases:

>100_bases
TCCAGGTGGGGTGGGCGGTATCCTCCTGCCAGGCGCTATCTTCAATACGAAAACCAAGCGCATGGTAGAAGTTTACGGCG
GATTGATTTTTCTGGTAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MTHVPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFPMVRKGFLASPDKPQGIRGQD
EFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSNGVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVV
GGNEVYQQQTSWPVVLEHSEVVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
PHMGTDVALMLGIAHTLVENDWQDEAFLARCTTGYDRFADYLLGKTDGTAKTAEWAAEICGVSAVKIRELAEIFHHNTTM
LMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFSYHFANGGNPTRRAAVLASMQGSIPGGVDAVDKIPVARIVE
ALENPGGFYQHNGMDRRFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFYNIAAQRGASQGVTLPPFAAF
WQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKIEIYSARIASYGYADCPGHPMWLVPDEWHGNADAGQVQLLS
AHPAHRLHSQLNYSSLRERYAVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS

Sequences:

>Translated_777_residues
MTHVPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFPMVRKGFLASPDKPQGIRGQD
EFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSNGVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVV
GGNEVYQQQTSWPVVLEHSEVVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
PHMGTDVALMLGIAHTLVENDWQDEAFLARCTTGYDRFADYLLGKTDGTAKTAEWAAEICGVSAVKIRELAEIFHHNTTM
LMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFSYHFANGGNPTRRAAVLASMQGSIPGGVDAVDKIPVARIVE
ALENPGGFYQHNGMDRRFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFYNIAAQRGASQGVTLPPFAAF
WQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKIEIYSARIASYGYADCPGHPMWLVPDEWHGNADAGQVQLLS
AHPAHRLHSQLNYSSLRERYAVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS
>Mature_776_residues
THVPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFPMVRKGFLASPDKPQGIRGQDE
FVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSNGVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVG
GNEVYQQQTSWPVVLEHSEVVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIAP
HMGTDVALMLGIAHTLVENDWQDEAFLARCTTGYDRFADYLLGKTDGTAKTAEWAAEICGVSAVKIRELAEIFHHNTTML
MAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFSYHFANGGNPTRRAAVLASMQGSIPGGVDAVDKIPVARIVEA
LENPGGFYQHNGMDRRFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDLT
MTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFYNIAAQRGASQGVTLPPFAAFW
QANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKIEIYSARIASYGYADCPGHPMWLVPDEWHGNADAGQVQLLSA
HPAHRLHSQLNYSSLRERYAVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDPE
PTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=777, Percent_Identity=85.5855855855856, Blast_Score=1405, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=774, Percent_Identity=64.9870801033592, Blast_Score=1065, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=794, Percent_Identity=44.080604534005, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI87081797, Length=749, Percent_Identity=32.0427236315087, Blast_Score=293, Evalue=3e-80,
Organism=Escherichia coli, GI1787870, Length=752, Percent_Identity=30.718085106383, Blast_Score=288, Evalue=1e-78,
Organism=Escherichia coli, GI171474008, Length=743, Percent_Identity=30.2826379542396, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI3868721, Length=474, Percent_Identity=23.4177215189873, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 85865; Mature: 85734

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHVPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFP
CCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEECH
MVRKGFLASPDKPQGIRGQDEFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSN
HHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQTSWPVVLEHSE
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCEEECCHHHHHHCCCCCEEEECCC
VVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
EEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCHHHHC
PHMGTDVALMLGIAHTLVENDWQDEAFLARCTTGYDRFADYLLGKTDGTAKTAEWAAEIC
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
GVSAVKIRELAEIFHHNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFS
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCHHEEHHHHHHCCCCCCCCCCEE
YHFANGGNPTRRAAVLASMQGSIPGGVDAVDKIPVARIVEALENPGGFYQHNGMDRRFPD
EEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCC
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
EEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCC
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFY
EEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
NIAAQRGASQGVTLPPFAAFWQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKI
HHHHHCCCCCCCCCCCHHHHHHCCCCEECCCCCCCCEEEEEEHHCCCCCCCCCCCCCCEE
EIYSARIASYGYADCPGHPMWLVPDEWHGNADAGQVQLLSAHPAHRLHSQLNYSSLRERY
EEEEEEHHCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHH
AVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
HHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHCCCCCCEEEEECCCCCCC
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS
CCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
THVPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFP
CCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEECH
MVRKGFLASPDKPQGIRGQDEFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSN
HHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQTSWPVVLEHSE
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCEEECCHHHHHHCCCCCEEEECCC
VVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
EEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCHHHHC
PHMGTDVALMLGIAHTLVENDWQDEAFLARCTTGYDRFADYLLGKTDGTAKTAEWAAEIC
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
GVSAVKIRELAEIFHHNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFS
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCHHEEHHHHHHCCCCCCCCCCEE
YHFANGGNPTRRAAVLASMQGSIPGGVDAVDKIPVARIVEALENPGGFYQHNGMDRRFPD
EEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCC
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
EEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCC
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFY
EEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
NIAAQRGASQGVTLPPFAAFWQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKI
HHHHHCCCCCCCCCCCHHHHHHCCCCEECCCCCCCCEEEEEEHHCCCCCCCCCCCCCCEE
EIYSARIASYGYADCPGHPMWLVPDEWHGNADAGQVQLLSAHPAHRLHSQLNYSSLRERY
EEEEEEHHCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHH
AVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
HHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHCCCCCCEEEEECCCCCCC
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS
CCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]