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The map label for this gene is lysR [H]

Identifier: 194737023

GI number: 194737023

Start: 3078351

End: 3079286

Strand: Direct

Name: lysR [H]

Synonym: SeSA_A3182

Alternate gene names: 194737023

Gene position: 3078351-3079286 (Clockwise)

Preceding gene: 194736198

Following gene: 194734909

Centisome position: 65.37

GC content: 57.91

Gene sequence:

>936_bases
ATGGCTGCCGTTAATTTACGTCACATTGAAATTTTTCATGCCGTAATGACCGCCGGAAATCTCACCGAAGCGGCGCGGCT
GCTGCATACCTCGCAGCCTACCGTCAGTCGCGAGCTGGCGCGTTTTGAGAAAGTGCTGGGATTAACGCTGTTTGAGCGCA
CACGCGGGCGCTTACATCCGACGGTGCAAGGGCTACGCCTGTTCGAAGAGGTACAACGCTCCTGGTATGGGTTGGATCGT
ATCGTCAGCGCGGCGGAAAGTCTGCGCGAGTTCCGTCAGGGCGAACTCTCTATCGCCTGCCTGCCGGTCTTTTCACAATC
CTTTTTGCCGCCGCTACTACCGCCTTTTCTGGCGCGTTATCCGGATGTCAGCCTGAATATTGTGCCGCAGGAGTCGCCGT
TGCTGGAAGAGTGGCTCTCCGCTCAGCGCCACGATTTAGGGCTGACGGAGACGCTTCATGCCCCGGCAGGAACAACCCGT
ACCGAGTTACTAACGCTAAATGAAGTGTGCGTACTGCCCTGCGACCATCCGCTTACCGCCAAAACGGTACTGACGCCAGA
CGATTTTCAGGGGGAAAACTTTATCAGCCTCTCCCGCCTGGACAGCTATCGACAGTTGTTGGATACGTTATTTGCCGAAC
ATCAGGTGAAGCGCAGAATGGTGGTGGAAACGCATAGCGCGGCCTCCGTCTGCGCGATGGTGCGCGCCGGAGCGGGCGTT
TCGATCGTTAACCCGCTGACCGCGCTGGACTATGCCGCCAGCAGCGTCACCGTTCGCCGCTTCAGCATTGACGTGCCCTT
TACCGTCAGCCTGATTCGCCCGCTACACCGCCCCGCCTCCGCGCTGGTTGACGCCTTCAGTAAGCATTTACAAACGCATC
TTTCGCGCCTGGTCGAACCGCTGGAGGTTATTCTGGGGCCGATGACGAAAGCATAA

Upstream 100 bases:

>100_bases
GCTTTTTAACGATTACGCCATACCTTAGAAAGAATAAAAAATATCGTTTTATTGTCAGTCTATGCAAAAATGATATGGGA
TAAATGATTCAGGGAAACGT

Downstream 100 bases:

>100_bases
AGCTCACGGCATCTGCGGCATGAATTGCCGTGGTATCGAAAACCGGTAGCGCGCTTTGCGTCTGGGGAACAAGCAAACCT
ATTTCAGTGCAGCCAAAAAT

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTR
TELLTLNEVCVLPCDHPLTAKTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
SIVNPLTALDYAASSVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEPLEVILGPMTKA

Sequences:

>Translated_311_residues
MAAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTR
TELLTLNEVCVLPCDHPLTAKTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
SIVNPLTALDYAASSVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEPLEVILGPMTKA
>Mature_310_residues
AAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHPTVQGLRLFEEVQRSWYGLDRI
VSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTRT
ELLTLNEVCVLPCDHPLTAKTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGVS
IVNPLTALDYAASSVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEPLEVILGPMTKA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=311, Percent_Identity=86.1736334405145, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI157672245, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI145693105, Length=270, Percent_Identity=25.5555555555556, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788887, Length=275, Percent_Identity=28, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790262, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788297, Length=242, Percent_Identity=24.7933884297521, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788481, Length=298, Percent_Identity=24.496644295302, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790208, Length=306, Percent_Identity=26.797385620915, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=129, Percent_Identity=35.6589147286822, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=26.6932270916335, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34594; Mature: 34463

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHP
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCHHHHHC
PDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTRTELLTLNEVCVLPCDHPLTA
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHEEEECCEEEEECCCCCCC
KTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
EEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SIVNPLTALDYAASSVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEP
CHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LEVILGPMTKA
HHHHHCCCCCC
>Mature Secondary Structure 
AAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHP
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCHHHHHC
PDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTRTELLTLNEVCVLPCDHPLTA
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHEEEECCEEEEECCCCCCC
KTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
EEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SIVNPLTALDYAASSVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEP
CHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LEVILGPMTKA
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]