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The map label for this gene is adiC [H]

Identifier: 194736542

GI number: 194736542

Start: 4426749

End: 4428086

Strand: Reverse

Name: adiC [H]

Synonym: SeSA_A4549

Alternate gene names: 194736542

Gene position: 4428086-4426749 (Counterclockwise)

Preceding gene: 194737377

Following gene: 194737369

Centisome position: 94.03

GC content: 56.35

Gene sequence:

>1338_bases
ATGTCTTCGGATGCTGATGCTCACAAAGTGGGCCTAATCCCCGTCACCTTAATGGTATCGGGGAATATTATGGGTTCAGG
GGTATTCTTACTCCCTGCCAACCTGGCAGCCACTGGCGGGATTGCAATCTACGGATGGCTGGTCACTATCATCGGCGCCC
TGGCGCTGTCGATGGTTTATGCCAAAATGTCGTCCTTAGATCCCAGTCCCGGCGGTTCCTATGCCTACGCACGTCGCTGC
TTCGGGCCGTTTTTGGGCTATCAAACGAACGTGCTGTACTGGCTGGCATGCTGGATCGGTAATATCGCGATGGTCGTTAT
CGGCGTCGGCTATCTGAGCTATTTCTTCCCGATTCTGAAAGATCCGCTGGTATTAACGCTTACCTGCGTCGCGGTGCTGT
GGATTTTTGTTCTGCTGAACATCGTCGGGCCGAAAATGATTACCCGCGTACAGGCCGTCGCCACCGTACTGGCGCTGGTG
CCTATCGTAGGGATTGCGGTCTTCGGCTGGTTCTGGTTTAAAGGCGAAACCTATATGGCGGCCTGGAACGTGAGCGGCAT
GAATACCTTCGGCGCGATTCAAAGCACGTTGAACGTTACGCTGTGGTCATTCATCGGGGTAGAAAGCGCCTCCGTTGCGG
CCGGTGTGGTCAAAAACCCGAAACGCAACGTGCCTATCGCCACCATCGGCGGGGTACTGATCGCCGCCGTCTGCTATGTA
CTCTCCACAACGGCGATTATGGGGATGATCCCCAACGCAGCGCTGCGTGTGTTGGCATCGCCTTTCGGTGACGCGGCGCG
TATGGCGCTGGGCGATACCGCAGGGGCTATTGTTTCCTTCTGTGCGGCAGCAGGTTGCCTGGGCTCTCTCGGCGGCTGGA
CGCTGCTTGCCGGTCAAACCGCAAAAGCGGCGGCGGACGATGGTCTCTTCCCGCCAATCTTCGCACGGGTTAATAAAGCC
GGTACGCCAGTGGCTGGGTTGCTTATCGTCGGCGTGCTGATGACTATCTTCCAGTTCAGCAGTATGTCGCCGAACGCCGC
GAAAGAGTTTGGTCTGGTCTCCTCCGTGTCGGTTATCTTCACCCTGGTGCCTTATCTTTACACCTGTGCCGCGCTGTTGC
TGTTGGGCCACGGTCACTTTGGTAAAGCGCGCCCGCTGTATCTGCTGATTACCTTCGTCGCGTTTGTGTATTGCATCTGG
GCGGTCATCGGTTCCGGCGCCAAAGAAGTGATGTGGTCGTTCGTCACGTTGATGGTGATCACCGCGCTGTATGCGTTGAA
TTACAACCGCATTCACAAAAACCCGTATCCGCTGGATGCGCCGGTTAAACAGGATTGA

Upstream 100 bases:

>100_bases
TTGGCGATAACCCGTCTCCGACATAATTCAGCGGCATTCTGAGGGGGTATGATACGACGTAATTTATCGTAACGAAGTCA
CCTTTTCAGGAGTCCAAATT

Downstream 100 bases:

>100_bases
CCACGTGTAGTTAATGTTATCGCAACAGGCCGGATAGCGCAGGTTATCCGGCCGCCACCAACATTAAGTTCTTAAGGTTC
ACTTAATTTTACTTTGTCAC

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALV
PIVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVLASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIW
AVIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD

Sequences:

>Translated_445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALV
PIVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVLASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIW
AVIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD
>Mature_444_residues
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRCF
GPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALVP
IVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVL
STTAIMGMIPNAALRVLASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAG
TPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIWA
VIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=342, Percent_Identity=23.9766081871345, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=342, Percent_Identity=23.9766081871345, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI186910308, Length=354, Percent_Identity=24.5762711864407, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910306, Length=354, Percent_Identity=24.5762711864407, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910304, Length=354, Percent_Identity=24.5762711864407, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI187423910, Length=346, Percent_Identity=23.4104046242775, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI7657591, Length=346, Percent_Identity=23.4104046242775, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=93.9325842696629, Blast_Score=844, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=441, Percent_Identity=38.7755102040816, Blast_Score=297, Evalue=8e-82,
Organism=Escherichia coli, GI1786908, Length=441, Percent_Identity=33.1065759637188, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1787890, Length=427, Percent_Identity=29.2740046838407, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI87082250, Length=353, Percent_Identity=28.6118980169972, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=23.9024390243902, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790653, Length=393, Percent_Identity=23.6641221374046, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786302, Length=399, Percent_Identity=22.5563909774436, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786789, Length=370, Percent_Identity=21.6216216216216, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=413, Percent_Identity=25.181598062954, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71995382, Length=413, Percent_Identity=25.181598062954, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993915, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=333, Percent_Identity=25.2252252252252, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982612, Length=406, Percent_Identity=23.8916256157635, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=405, Percent_Identity=23.7037037037037, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=312, Percent_Identity=22.1153846153846, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=356, Percent_Identity=26.9662921348315, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17568033, Length=336, Percent_Identity=24.4047619047619, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221331183, Length=452, Percent_Identity=25.4424778761062, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17647653, Length=452, Percent_Identity=25.4424778761062, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664379, Length=452, Percent_Identity=25.4424778761062, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641993, Length=388, Percent_Identity=24.4845360824742, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641995, Length=388, Percent_Identity=24.4845360824742, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651635, Length=346, Percent_Identity=23.9884393063584, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24651633, Length=346, Percent_Identity=23.9884393063584, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46959; Mature: 46828

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVY
CCCCCCCCEECCEEEEEEEECCEEECCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHH
AKMSSLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALVPIVGIAVFGWFWFKGETYMA
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVLASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCC
AKAAADDGLFPPIFARVNKAGTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIWAVIGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TALYALNYNRIHKNPYPLDAPVKQD
HHHHHHCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVY
CCCCCCCEECCEEEEEEEECCEEECCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHH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HHHHHHCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]