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The map label for this gene is nuoF [H]

Identifier: 194736167

GI number: 194736167

Start: 2437750

End: 2439087

Strand: Reverse

Name: nuoF [H]

Synonym: SeSA_A2552

Alternate gene names: 194736167

Gene position: 2439087-2437750 (Counterclockwise)

Preceding gene: 194736216

Following gene: 194735527

Centisome position: 51.8

GC content: 58.37

Gene sequence:

>1338_bases
ATGAAAAACGTTATCCGTACTCCCGAAACCCATCCGCTGACCTGGCGTCTGCGCGATGACAAACAGCCGGTCTGGCTGGA
TGAATATCGTAGCAAAAACGGCTACGAAGGCGCGCGTAAGGCGCTGACCGGCCTGTCTCCGGATGAAATCGTCAGCCAGG
TAAAAGACGCCGGTCTGAAAGGGCGCGGCGGCGCGGGCTTTTCCACCGGTCTGAAGTGGAGCCTGATGCCGAAAGATGAA
TCCATGAACATCCGTTACCTGCTGTGTAACGCCGATGAAATGGAACCGGGCACCTATAAAGACCGTCTGCTGATGGAACA
GCTGCCGCACCTGCTGGTGGAAGGCATGCTGATCTCCGCGTTCGCGCTGAAAGCGTATCGTGGTTACATCTTCCTGCGCG
GCGAATATATCGAAGCGGCTGTACATCTGCGCCGTGCGATTGCTGAAGCCACCGAGGCCGGGCTGCTTGGCAAAAATATC
ATGGGCACCGGGTTCGACTTTGAACTGTTTGTCCACACCGGGGCAGGACGTTACATCTGTGGTGAAGAAACGGCGCTGAT
TAACTCCCTCGAAGGCCGTCGCGCGAACCCGCGCTCCAAGCCGCCCTTCCCGGCGACCTCCGGCGTATGGGGCAAGCCGA
CCTGTGTGAATAACGTCGAAACGTTGTGCAACGTCCCGGCAATCCTCGCCAACGGCGTGGAGTGGTACCAGAACATTTCG
AAAAGCAAAGATGCGGGTACCAAGCTGATGGGCTTCTCAGGCCGCGTGAAGAATCCGGGCCTGTGGGAATTACCGTTCGG
CACCACCGCGCGTGAGATCCTAGAAGATTATGCGGGCGGTATGCGCGATGGCCTGAAATTCAAAGCCTGGCAGCCGGGCG
GGGCGGGAACCGACTTCCTGACCGAGGCGCATCTTGACCTGCCGATGGAGTTCGAAAGCATCGGTAAAGCAGGCAGCCGT
CTGGGCACCGCGCTGGCGATGGCGGTAGACCACGAAATCGGCATGGTATCGCTGGTGCGTAACCTGGAAGAGTTCTTTGC
CCGCGAATCCTGCGGCTGGTGTACGCCATGCCGCGACGGGTTGCCGTGGAGCGTGAAAATTCTGCGCGCGCTGGAGCGTG
GCGAAGGCCAGCCGGGGGATATCGAGACACTTGAGCAACTGTGTCGTTTCCTCGGACCGGGTAAAACCTTCTGCGCGCAT
GCGCCGGGCGCGGTTGAGCCACTGCAAAGCGCAATTAAGTATTTCCGCGAAGAATTCGAAGCTGGCATCAAGCAGCCGTT
CAGTAATACCCATTTAATCAATGGTATTCAGCCGAACCTGCTCAAAGAGCGCTGGTGA

Upstream 100 bases:

>100_bases
GCCTGGGGAATTGCGATAAAGGGCCGAACATGATGATTGATGAGGATACTCACAGCCATCTGACCCCGGAAGCCATTCCT
GAACTACTGGAGCGGTATAA

Downstream 100 bases:

>100_bases
GTTAACGATTTTTAATTTGGAAGCATGCTAATGGCTACGATTCATGTAGACGGCAAAGAATACGAGGTCAACGGCGCGGA
CAACCTGCTACAGGCATGTC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKNVIRTPETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGLSPDEIVSQVKDAGLKGRGGAGFSTGLKWSLMPKDE
SMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVHLRRAIAEATEAGLLGKNI
MGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPATSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
KSKDAGTKLMGFSGRVKNPGLWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSR
LGTALAMAVDHEIGMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAH
APGAVEPLQSAIKYFREEFEAGIKQPFSNTHLINGIQPNLLKERW

Sequences:

>Translated_445_residues
MKNVIRTPETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGLSPDEIVSQVKDAGLKGRGGAGFSTGLKWSLMPKDE
SMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVHLRRAIAEATEAGLLGKNI
MGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPATSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
KSKDAGTKLMGFSGRVKNPGLWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSR
LGTALAMAVDHEIGMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAH
APGAVEPLQSAIKYFREEFEAGIKQPFSNTHLINGIQPNLLKERW
>Mature_445_residues
MKNVIRTPETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGLSPDEIVSQVKDAGLKGRGGAGFSTGLKWSLMPKDE
SMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVHLRRAIAEATEAGLLGKNI
MGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPATSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
KSKDAGTKLMGFSGRVKNPGLWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSR
LGTALAMAVDHEIGMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAH
APGAVEPLQSAIKYFREEFEAGIKQPFSNTHLINGIQPNLLKERW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=376, Percent_Identity=44.1489361702128, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI20149568, Length=376, Percent_Identity=44.1489361702128, Blast_Score=321, Evalue=1e-87,
Organism=Escherichia coli, GI1788620, Length=445, Percent_Identity=98.876404494382, Blast_Score=908, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17531727, Length=375, Percent_Identity=42.4, Blast_Score=304, Evalue=7e-83,
Organism=Drosophila melanogaster, GI19920794, Length=375, Percent_Identity=44.2666666666667, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI45550452, Length=378, Percent_Identity=43.6507936507937, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24653819, Length=377, Percent_Identity=34.4827586206897, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24653817, Length=352, Percent_Identity=32.3863636363636, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49246; Mature: 49246

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVIRTPETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGLSPDEIVSQVKDAGLK
CCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
GRGGAGFSTGLKWSLMPKDESMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISA
CCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FALKAYRGYIFLRGEYIEAAVHLRRAIAEATEAGLLGKNIMGTGFDFELFVHTGAGRYIC
HHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEE
GEETALINSLEGRRANPRSKPPFPATSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHH
KSKDAGTKLMGFSGRVKNPGLWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFL
CCCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCHHCCCEEEEECCCCCCCHHH
TEAHLDLPMEFESIGKAGSRLGTALAMAVDHEIGMVSLVRNLEEFFARESCGWCTPCRDG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAHAPGAVEPLQSAIKYFREEFE
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHH
AGIKQPFSNTHLINGIQPNLLKERW
HHHHCCCCCCCEECCCCHHHHHCCC
>Mature Secondary Structure
MKNVIRTPETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGLSPDEIVSQVKDAGLK
CCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
GRGGAGFSTGLKWSLMPKDESMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISA
CCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FALKAYRGYIFLRGEYIEAAVHLRRAIAEATEAGLLGKNIMGTGFDFELFVHTGAGRYIC
HHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEE
GEETALINSLEGRRANPRSKPPFPATSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHH
KSKDAGTKLMGFSGRVKNPGLWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFL
CCCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCHHCCCEEEEECCCCCCCHHH
TEAHLDLPMEFESIGKAGSRLGTALAMAVDHEIGMVSLVRNLEEFFARESCGWCTPCRDG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAHAPGAVEPLQSAIKYFREEFE
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHH
AGIKQPFSNTHLINGIQPNLLKERW
HHHHCCCCCCCEECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]