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The map label for this gene is dmsA [H]

Identifier: 194736122

GI number: 194736122

Start: 2665127

End: 2667505

Strand: Reverse

Name: dmsA [H]

Synonym: SeSA_A2769

Alternate gene names: 194736122

Gene position: 2667505-2665127 (Counterclockwise)

Preceding gene: 194734438

Following gene: 194736835

Centisome position: 56.65

GC content: 54.77

Gene sequence:

>2379_bases
ATGAAAAATATAAAAAGCCAGGGAAATGGCGAACAGCCCGCTATTTCTCGCCGCCATTTTATCCAGGCCAGCTCCGCGCT
TATTGCGTTACCGTTTGTCTCCTCGCCAGCTACCGCTCAGGCGCGCGCTGTGACGGCCACTGAAAACAGGCCTGCGGAAA
AAGTCGTCCAGACATGCAGCACTTTTGACTGCGGGGGCAAATGCGATATTCGGGCGCATGTCAGTGAAGGTATCGTGACG
CGAATTTCAACGCGACCGGATAATGCGCTGGATGCGCAAATGCCGGTGATGCGTGCCTGTGTTCGTGGACGCGCATACCG
TAAATTTGTTTATCATCCTGACAGACTTAAATATCCCATGAAGCGCGTAGGAAAACGCGGTGAAGGAAAATTCGAGCGAA
TTTCCTGGGATGAAGCGACAACCTTAATCGCCGATAATTTAAAATCGATTACTGAAAAATATGGCCCGGCTTCGCGCTAT
GTTCATGTTGGTACCGCCGTTTCCGGCGGCACCTTTTCTGGCGATAAAATGGCGCGTCGCCTGCTGAATCTGACCGGCGG
CTATCTCGAAAGCTACCATTCTGTGAGTATGGGCAACACGGCGGCCGCGACGCCTTATACTTACGGCATTGCCGCCAGCG
GCAGTTCACTGGATACGCTTTTGGAGACCAAACTGGTGATTCTGTGGGGCCATAACCCGACGGAGACCATTTTTGGTCAT
ACCAACTATTTCTTGCAGAAGATGAAGCAGAACGGTACGCGGTTTATCGTGGTCGATCCGCGCTATTCCGACACCGTTTC
GTCGCTGGCGGATCAGTGGATCCCGCTACTGCCCACCACCGACAATGCGCTGATGGACGCGATGATGTACGTCATCATCA
GCGAGAATCTGCACGATCGTGCATTTATTGCGCGCTACGCTATCGGTTTTGACGAAGAATCAATGCCGGAAGGCGTACCG
GCTAACGAATCGCTGGTGGCGTATCTGACCGGCGCCAAAGACGGTGTCGTTAAGTCCCCCGAGTGGGCGGAAAAGATCAC
CCATGTGCCGGCGCAAACCATTCGCCAGTTAGCGCGTGATTACGCGAATACCAAACCCGCCGCGTTGATTCAGGGGTGGG
GACCACAGCGCCACAACTGCGGCGAGCGCACCGCGCGCGGCTCGACTCTACTGGCGACCATTACCGGTAATGTCGGCATC
AAAGGCGGTTGGGCTGCGGGTTACGGCGGCTGCGCTAACCGTAAATTTGCCGCGGGTCCGGAGATGCCGGATAACCCGGT
AAAAGCCAAAATTTCGGTGATGAACTGGGTGCAGGCCGCAGACGACGCCAGCAAAGTGACGCCGGATATTGGACTGAAAG
ATGCCGATAAGCTGGACAGTAACATCCGTATTCTGTTCTCGCTGGCCGGGAACTATCTGGCGAATCAGAACCCCGATCTG
CACCAGGCGGTACGCGTACTGGAGGATGAATCAAAGATCCAGTTTATTGTCGCCAGCGATCTGTTTATGACGCCGAGCGC
GAAATACGCTGATCTACTGCTGCCGGAAACCAGCTTTATGGAACGCTGGAACATCGGTGAAACCTGGGGTACGGCAAGCT
ACCTGATGCTCTCTGAAAAACTGATCGAGCCTGAATTTGAGCGGCGCTCCGACTACGACTGGCTACGTGAGGTGGCGGCG
AAATTAGGCATTGAGAATGAATTTAGCCAGGGGCGCGATGAGAAAGCGTGGATTGAACACATCTGGGAACAGACGCGCCT
GGCGATGCCGGAAGAAAATCTGCCGGATTTCGCCACGCTGCAAAAGACCCGTCAGCATCTGTTCAAAAGCGCGCCATTTA
TCGCCTTTGAAGACAATATTCGCGATCCGGACAATCATCCATTCCCGACGCCGTCAGGGAAAATAGAGATCTTCTCGAAG
CGCCTCTACGACATGCAGCATCCGGAAATCCCGGCGTTATCGCACTACGTTCCCGCGCATGAAGGCCCGGAGGATGCGCT
GGCGAAAGATTTTCCGCTCCAGTTAATTACGTGGAAAGGAAAAAACCGCGCCAACTCAACGCAATACGCTAACCCGTGGC
TGATTGAAGTGCAGCATCAGACATTGTGGATCAACCCGCAGGATGCGCAAAAGCGCGGCATTACGCATGGCGACATGGTG
CGCATTCATAACTCACGCGGGATTTGCGAAATCCCGGCGGAAGTGACGCCGCGCATTATTCCTGGCGTTGTCGCGATGCA
GGCCGGCGCCTGGTGGCAGCCGGATGAGAACGGTATTGATAAAGGCGGCTGTGCGAACGTCCTCAGCTCGGCCCGTATTA
CCGCGCTGGCGAAGGGAAATTCACATCAAACCATGCTGGTGGAGGTGGCTAAAGCATGA

Upstream 100 bases:

>100_bases
TTAATTTTCCGGAATTACCCTTAATGAGGGAGCTTGATAAATATCAAGAGATCTAACACTTAAAAACGTGAGAATGGGTT
TTTATTTGACGAGTCGGATC

Downstream 100 bases:

>100_bases
GTCAGTTTACACATTACCCGCCGGTGAGCGATAAACAACTGGGGTTTTTCATCGACTCCTCACGCTGCTCCGGTTGTAAA
GCCTGCCAGGTGGCCTGCAA

Product: anaerobic dimethyl sulfoxide reductase chain a

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 792; Mature: 792

Protein sequence:

>792_residues
MKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCSTFDCGGKCDIRAHVSEGIVT
RISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRY
VHVGTAVSGGTFSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLETKLVILWGHNPTETIFGH
TNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDRAFIARYAIGFDEESMPEGVP
ANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGI
KGGWAAGYGGCANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDIGLKDADKLDSNIRILFSLAGNYLANQNPDL
HQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLMLSEKLIEPEFERRSDYDWLREVAA
KLGIENEFSQGRDEKAWIEHIWEQTRLAMPEENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPDNHPFPTPSGKIEIFSK
RLYDMQHPEIPALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQHQTLWINPQDAQKRGITHGDMV
RIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGIDKGGCANVLSSARITALAKGNSHQTMLVEVAKA

Sequences:

>Translated_792_residues
MKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCSTFDCGGKCDIRAHVSEGIVT
RISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRY
VHVGTAVSGGTFSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLETKLVILWGHNPTETIFGH
TNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDRAFIARYAIGFDEESMPEGVP
ANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGI
KGGWAAGYGGCANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDIGLKDADKLDSNIRILFSLAGNYLANQNPDL
HQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLMLSEKLIEPEFERRSDYDWLREVAA
KLGIENEFSQGRDEKAWIEHIWEQTRLAMPEENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPDNHPFPTPSGKIEIFSK
RLYDMQHPEIPALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQHQTLWINPQDAQKRGITHGDMV
RIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGIDKGGCANVLSSARITALAKGNSHQTMLVEVAKA
>Mature_792_residues
MKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCSTFDCGGKCDIRAHVSEGIVT
RISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRY
VHVGTAVSGGTFSGDKMARRLLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLETKLVILWGHNPTETIFGH
TNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDRAFIARYAIGFDEESMPEGVP
ANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARDYANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGI
KGGWAAGYGGCANRKFAAGPEMPDNPVKAKISVMNWVQAADDASKVTPDIGLKDADKLDSNIRILFSLAGNYLANQNPDL
HQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLMLSEKLIEPEFERRSDYDWLREVAA
KLGIENEFSQGRDEKAWIEHIWEQTRLAMPEENLPDFATLQKTRQHLFKSAPFIAFEDNIRDPDNHPFPTPSGKIEIFSK
RLYDMQHPEIPALSHYVPAHEGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQHQTLWINPQDAQKRGITHGDMV
RIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGIDKGGCANVLSSARITALAKGNSHQTMLVEVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=809, Percent_Identity=42.274412855377, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI171474008, Length=801, Percent_Identity=41.9475655430712, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1787870, Length=812, Percent_Identity=40.1477832512315, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI145693196, Length=734, Percent_Identity=30.1089918256131, Blast_Score=268, Evalue=1e-72,
Organism=Escherichia coli, GI1787231, Length=751, Percent_Identity=28.4953395472703, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87081994, Length=722, Percent_Identity=28.9473684210526, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI3868721, Length=790, Percent_Identity=26.4556962025316, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787741, Length=284, Percent_Identity=27.4647887323944, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI3868720, Length=458, Percent_Identity=22.707423580786, Blast_Score=83, Evalue=9e-17,
Organism=Escherichia coli, GI3868719, Length=462, Percent_Identity=22.7272727272727, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788534, Length=557, Percent_Identity=22.4416517055655, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 87753; Mature: 87753

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCS
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHC
TFDCGGKCDIRAHVSEGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPM
CCCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHCCHH
KRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRYVHVGTAVSGGTFSGDKMARR
HHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHH
LLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLETKLVILWGHNPTETIFGH
HHHHCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHCCEEEEEECCCCCCCEECC
TNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDR
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
AFIARYAIGFDEESMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARD
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
YANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGIKGGWAAGYGGCANRKFAAGP
HCCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
EMPDNPVKAKISVMNWVQAADDASKVTPDIGLKDADKLDSNIRILFSLAGNYLANQNPDL
CCCCCCCCEEHHHHHHHHHCCCHHHCCCCCCCCCHHHCCCCCEEEEEECCCHHCCCCCCH
HQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLMLSEK
HHHHHHHCCCCCEEEEEECCEEECCCCCHHHEECCCHHHHHHCCCCCCCCCHHHHHHHHH
LIEPEFERRSDYDWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPEENLPDFATL
HCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
QKTRQHLFKSAPFIAFEDNIRDPDNHPFPTPSGKIEIFSKRLYDMQHPEIPALSHYVPAH
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCHHHCCCCC
EGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQHQTLWINPQDAQKRGITHGDMV
CCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCEEEECCCHHHHCCCCCCCEE
RIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGIDKGGCANVLSSARITALAKGN
EEECCCCEEECCHHCCCCHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCC
SHQTMLVEVAKA
CCCEEEEEEECC
>Mature Secondary Structure
MKNIKSQGNGEQPAISRRHFIQASSALIALPFVSSPATAQARAVTATENRPAEKVVQTCS
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHC
TFDCGGKCDIRAHVSEGIVTRISTRPDNALDAQMPVMRACVRGRAYRKFVYHPDRLKYPM
CCCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHCCHH
KRVGKRGEGKFERISWDEATTLIADNLKSITEKYGPASRYVHVGTAVSGGTFSGDKMARR
HHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHH
LLNLTGGYLESYHSVSMGNTAAATPYTYGIAASGSSLDTLLETKLVILWGHNPTETIFGH
HHHHCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHCCEEEEEECCCCCCCEECC
TNYFLQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDR
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
AFIARYAIGFDEESMPEGVPANESLVAYLTGAKDGVVKSPEWAEKITHVPAQTIRQLARD
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
YANTKPAALIQGWGPQRHNCGERTARGSTLLATITGNVGIKGGWAAGYGGCANRKFAAGP
HCCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
EMPDNPVKAKISVMNWVQAADDASKVTPDIGLKDADKLDSNIRILFSLAGNYLANQNPDL
CCCCCCCCEEHHHHHHHHHCCCHHHCCCCCCCCCHHHCCCCCEEEEEECCCHHCCCCCCH
HQAVRVLEDESKIQFIVASDLFMTPSAKYADLLLPETSFMERWNIGETWGTASYLMLSEK
HHHHHHHCCCCCEEEEEECCEEECCCCCHHHEECCCHHHHHHCCCCCCCCCHHHHHHHHH
LIEPEFERRSDYDWLREVAAKLGIENEFSQGRDEKAWIEHIWEQTRLAMPEENLPDFATL
HCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
QKTRQHLFKSAPFIAFEDNIRDPDNHPFPTPSGKIEIFSKRLYDMQHPEIPALSHYVPAH
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCHHHCCCCC
EGPEDALAKDFPLQLITWKGKNRANSTQYANPWLIEVQHQTLWINPQDAQKRGITHGDMV
CCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCEEEECCCHHHHCCCCCCCEE
RIHNSRGICEIPAEVTPRIIPGVVAMQAGAWWQPDENGIDKGGCANVLSSARITALAKGN
EEECCCCEEECCHHCCCCHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCC
SHQTMLVEVAKA
CCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]