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The map label for this gene is nuoN [H]

Identifier: 194736101

GI number: 194736101

Start: 2427690

End: 2429147

Strand: Reverse

Name: nuoN [H]

Synonym: SeSA_A2544

Alternate gene names: 194736101

Gene position: 2429147-2427690 (Counterclockwise)

Preceding gene: 194736746

Following gene: 194738031

Centisome position: 51.58

GC content: 59.74

Gene sequence:

>1458_bases
ATGACAATAACTCCACAACACCTGATTGCGCTGCTACCGCTGCTGATCGTCGGCTTGACGGTGGTGGTTGTGATGCTCTC
CATTGCGTGGCGACGCAATCACTTCCTCAATGCCACGCTGTCGGTCATTGGGCTTAACGCTGCTCTGGTTTCGCTTTGGT
TTGTCGGCCAGGCCGGGGCAATGGACGTCACGCCGCTGATGCGCGTTGACGGCTTTGCGATGCTCTACACCGGGCTGGTG
CTGCTGGCGAGCCTCGCCACCTGCACCTTTGCCTACCCGTGGCTGGAAGGCTATAACGATAACCAGGAAGAGTTCTACCT
GCTGGTGTTAATCGCCAGCCTGGGGGGAATTCTGCTGGCGAACGCCAACCACCTGGCGGCGCTGTTCCTTGGTATTGAAC
TGATCTCGCTGCCGCTGTTCGGCCTGATTGGTTATGCTTTCCGCCAGAAGCGCTCGCTGGAAGCCAGTATCAAATACACC
ATCCTCTCCGCCGCCGCCTCGTCTTTCCTGCTGTTCGGGATGGCGCTGGTCTATGCGCAGTCCGGCAACCTGTCTTTCGA
AGCGCTCGGTAAGAGCCTCGGTGATGGTATGCTGCACGAGCCGTTGCTGCTGGCGGGCTTTGGCCTGATGATTGTCGGTC
TGGGCTTTAAACTCTCTCTGGTGCCGTTTCACCTGTGGACGCCAGACGTTTACCAGGGCGCGCCTGCGCCGGTTTCCACC
TTCCTGGCGACGGCGAGCAAAATCGCTATCTTCGGCGTGGTGATGCGTCTGTTCCTCTATGCGCCGGTAGGCGACAGCGA
AGCGGTACGCGTGGTGCTGGGCATTATCGCCTTTGCCTCTATCATCTTCGGTAACCTGATGGCGCTGAGCCAGACCAACA
TCAAACGTCTGCTCGGTTACTCTTCTATCTCTCACCTCGGCTATCTGCTGGTGGCGCTGATTGCCCTGCAGAGCGGCGAG
ATGTCGATGGAAGCGGTAGGCGTTTATCTGGCCGGTTATCTGTTCAGCAGCCTCGGTGCGTTTGGCGTGGTTAGCCTGAT
GTCCAGCCCGTTCCGCGGCCCGGATGCCGATTCCCTGTACTCTTACCGTGGTCTGTTCTGGCACCGTCCGGTTCTTGCCG
CGGTGATGACGGTGATGATGCTGTCGCTGGCAGGTATCCCGATGACGCTGGGCTTTATCGGCAAATTCTACGTGCTGGCG
GTCGGCGTTCAGGCCAGCCTGTGGTGGCTGGTCGCCGCCGTGGTGGTGGGTTCCGCGATTGGTTTGTACTACTACCTGCG
TGTTGCGGTGAGTCTCTACCTGCACGCGCCGCAGCAACCGGGACGCGACGCGCCGACAAACTGGCAGTACAGCGCGGGTG
GGATCGTGGTGCTGATCTCCGCGTTGCTGGTGTTGGTACTGGGCGTCTGGCCGCAGCCGCTGATTAGCCTTGTGCAGTTA
GCGACGCCGTTGATGTAA

Upstream 100 bases:

>100_bases
CTTCTATCCGCAGCCGATTCTGGATACCTCGCATTCTGCGATGAGCAACATCCAGCAGTGGTTTGTTAATTCTGTTACTA
CTACAAGGCCGTAAATCGCC

Downstream 100 bases:

>100_bases
GCAATAAGTAAAAACGAAAAACCCGCTTCACGAAGCGGGTTTTTTATTATCTGATGTAATGCGTTGAAATAACTATGGAT
TGTAGGCCGGATAAGGCGCT

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLV
LLASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLANANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYT
ILSAAASSFLLFGMALVYAQSGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVST
FLATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQSGE
MSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLYSYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLA
VGVQASLWWLVAAVVVGSAIGLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQL
ATPLM

Sequences:

>Translated_485_residues
MTITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLV
LLASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLANANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYT
ILSAAASSFLLFGMALVYAQSGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVST
FLATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQSGE
MSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLYSYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLA
VGVQASLWWLVAAVVVGSAIGLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQL
ATPLM
>Mature_484_residues
TITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVL
LASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLANANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYTI
LSAAASSFLLFGMALVYAQSGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTF
LATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQSGEM
SMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLYSYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLAV
GVQASLWWLVAAVVVGSAIGLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQLA
TPLM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=321, Percent_Identity=21.183800623053, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI251831117, Length=406, Percent_Identity=18.7192118226601, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI145693160, Length=485, Percent_Identity=95.2577319587629, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI1788831, Length=205, Percent_Identity=32.1951219512195, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788829, Length=324, Percent_Identity=25.6172839506173, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788613, Length=376, Percent_Identity=27.3936170212766, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788827, Length=322, Percent_Identity=27.639751552795, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788614, Length=437, Percent_Identity=24.9427917620137, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51984; Mature: 51852

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLA
CCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEE
NANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVST
CCCCCHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCCCCCHHHH
FLATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGY
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSISHLGYLLVALIALQSGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
SYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQASLWWLVAAVVVGSAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
ATPLM
HCCCC
>Mature Secondary Structure 
TITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLA
CCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEE
NANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVST
CCCCCHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCCCCCHHHH
FLATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGY
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSISHLGYLLVALIALQSGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
SYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQASLWWLVAAVVVGSAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
ATPLM
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA