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The map label for this gene is uidB [H]

Identifier: 194735793

GI number: 194735793

Start: 3197110

End: 3198483

Strand: Direct

Name: uidB [H]

Synonym: SeSA_A3314

Alternate gene names: 194735793

Gene position: 3197110-3198483 (Clockwise)

Preceding gene: 194735430

Following gene: 194734132

Centisome position: 67.89

GC content: 51.24

Gene sequence:

>1374_bases
ATGAACCAGCCGCTTTCCTGGCGCGTTATCGTAGGCTACAGCCTGGGTGATGTTGCCAATAATTTCGCCTTCGCCATGGG
GGCGCTGTTCCTGCTAAGTTATTACACCGACGTCGCAGGCGTCGGTGCCGCCGCTGCCGGTACGATGCTCTTACTGGTAC
GAATATTTGACGCCTTCGCCGATGTGGTGGCGGGACGCATAGTAGATAGTGTAAATACCCGCTGGGGGAAATTTCGCCCG
TTCCTGCTGTTCGGATCGGCGCCGTTAATGCTGTTTAGCGTACTGGTATTCTGCGTCCCGGCAGAGTGGAGTCATAGCAA
CAAAGTTATTTACGCATATCTCACCTATATGGGACTTGGGTTCTGCTATAGCATGGTCAATATTCCCTATGGATCGCTGG
CGACGGCAATGACTCAGGAACCGCGTTCGCGCGCCCGTCTCGGCGCGGCGCGCAGTATTGCGGCCTCGCTAACGTTTGTC
TGTCTGGCCTTCCTGATCGGGCCGCGTATTACTCATTCCAGCCCGACAGAAATGGCGTCGGTCTACCTCTTCTGGACCAT
TATCCTGGCCATTGCCGGTATGGCGCTGTATTTCATCTGTTTTAAATCTACCCGCGAAAACGTGGTGCGTATCGTCGCGC
AGCCGTCGTTAAAAATCAGTCTGCAAACGCTTAAACAGAACCGCCCGCTAATGATGCTTTGTACCGGCGCGCTATGCATT
CTGATCTCGACCTTCGCCGTCAGCGCATCGTCACTGTTCTATGTACGCTATGTTTTGAATGATACCGCCCTTTTCTCGGT
TATCGTGCTGGTACAAATGCTGGTAGGTTCTGTGGCGTCAGCACCTCTGGTTCCCCGTCTGGTGGCGAAGATAGGTAAGA
AGAATACCTTCCTGGCGGGCGCCTTAATGGGCACCCTTGGGTATTTGCTTTTCTTTTATATGTCTGACCATTCAGTGCCC
GTGGCCTTAACCGCTCTGGCGATTGCCGCTATTGGCCAGGGGATCACCATGACGGTAATGTGGGCGCTGGAGGCGGATAC
CGTGGAGTACGGCGAATATCTCACGGGCGTGCGCATAGAAGGTCTGACTTACTCGCTATTTTCTTTTACCCGTAAATGCG
GCCAGGCTATCGGCGGTTCTATTCCGGCCTTTATTCTTGGGTTAAGTGGCTATATCGCCAATCAGACGCAGACGCCGGAA
GTCATTACCGGTATCCGGATGTCTATATCGCTCATACCGTGCGGCTTTATGTTACTGGCTTTTATTATTATTTGGTTTTA
CCCATTAACGGATAATAAATTTAAGGAGATTGTTCAGGAGATAGATAAACGAAAACAGTCACAGCAACAACTTATTAAAG
ATTTTAATAAATAG

Upstream 100 bases:

>100_bases
TTTTTACCCGCGACAGAAGACCAAAATCGGCGGCCTTTATACTGCAAAAACGCTGGACCGGTATGACCTTCGGCGAAAAG
CCACAGCAGGGAGAGAAATC

Downstream 100 bases:

>100_bases
CTTTTCGATAACAATAATATACAACAGGTTAAACAATGAAAAAATTCGCGAAGATAGCGGCTATTCCAATAGCAGTAGTC
GCGGCCTGTCCTTCTGCCCT

Product: glucuronide transporter

Products: Proton [Cytoplasm]; Glucuronides [Cytoplasm] [C]

Alternate protein names: Glucuronide permease [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNQPLSWRVIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRIFDAFADVVAGRIVDSVNTRWGKFRP
FLLFGSAPLMLFSVLVFCVPAEWSHSNKVIYAYLTYMGLGFCYSMVNIPYGSLATAMTQEPRSRARLGAARSIAASLTFV
CLAFLIGPRITHSSPTEMASVYLFWTIILAIAGMALYFICFKSTRENVVRIVAQPSLKISLQTLKQNRPLMMLCTGALCI
LISTFAVSASSLFYVRYVLNDTALFSVIVLVQMLVGSVASAPLVPRLVAKIGKKNTFLAGALMGTLGYLLFFYMSDHSVP
VALTALAIAAIGQGITMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQTQTPE
VITGIRMSISLIPCGFMLLAFIIIWFYPLTDNKFKEIVQEIDKRKQSQQQLIKDFNK

Sequences:

>Translated_457_residues
MNQPLSWRVIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRIFDAFADVVAGRIVDSVNTRWGKFRP
FLLFGSAPLMLFSVLVFCVPAEWSHSNKVIYAYLTYMGLGFCYSMVNIPYGSLATAMTQEPRSRARLGAARSIAASLTFV
CLAFLIGPRITHSSPTEMASVYLFWTIILAIAGMALYFICFKSTRENVVRIVAQPSLKISLQTLKQNRPLMMLCTGALCI
LISTFAVSASSLFYVRYVLNDTALFSVIVLVQMLVGSVASAPLVPRLVAKIGKKNTFLAGALMGTLGYLLFFYMSDHSVP
VALTALAIAAIGQGITMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQTQTPE
VITGIRMSISLIPCGFMLLAFIIIWFYPLTDNKFKEIVQEIDKRKQSQQQLIKDFNK
>Mature_457_residues
MNQPLSWRVIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRIFDAFADVVAGRIVDSVNTRWGKFRP
FLLFGSAPLMLFSVLVFCVPAEWSHSNKVIYAYLTYMGLGFCYSMVNIPYGSLATAMTQEPRSRARLGAARSIAASLTFV
CLAFLIGPRITHSSPTEMASVYLFWTIILAIAGMALYFICFKSTRENVVRIVAQPSLKISLQTLKQNRPLMMLCTGALCI
LISTFAVSASSLFYVRYVLNDTALFSVIVLVQMLVGSVASAPLVPRLVAKIGKKNTFLAGALMGTLGYLLFFYMSDHSVP
VALTALAIAAIGQGITMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQTQTPE
VITGIRMSISLIPCGFMLLAFIIIWFYPLTDNKFKEIVQEIDKRKQSQQQLIKDFNK

Specific function: Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by uidC (gusC, AC Q47706) [H]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Escherichia coli, GI1787902, Length=457, Percent_Identity=85.5579868708972, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI145693206, Length=453, Percent_Identity=32.8918322295806, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI48994989, Length=458, Percent_Identity=31.0043668122271, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786466, Length=462, Percent_Identity=30.3030303030303, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082306, Length=452, Percent_Identity=27.6548672566372, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1790561, Length=458, Percent_Identity=27.0742358078603, Blast_Score=158, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50021; Mature: 50021

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00527 RIBOSOMAL_S14 ; PS00872 NA_GALACTOSIDE_SYMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPLSWRVIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRIFDAFA
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DVVAGRIVDSVNTRWGKFRPFLLFGSAPLMLFSVLVFCVPAEWSHSNKVIYAYLTYMGLG
HHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHH
FCYSMVNIPYGSLATAMTQEPRSRARLGAARSIAASLTFVCLAFLIGPRITHSSPTEMAS
HHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VYLFWTIILAIAGMALYFICFKSTRENVVRIVAQPSLKISLQTLKQNRPLMMLCTGALCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCEEEHHHHHHHH
LISTFAVSASSLFYVRYVLNDTALFSVIVLVQMLVGSVASAPLVPRLVAKIGKKNTFLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
ALMGTLGYLLFFYMSDHSVPVALTALAIAAIGQGITMTVMWALEADTVEYGEYLTGVRIE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCEEEC
GLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQTQTPEVITGIRMSISLIPCGFMLLA
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FIIIWFYPLTDNKFKEIVQEIDKRKQSQQQLIKDFNK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQPLSWRVIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRIFDAFA
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DVVAGRIVDSVNTRWGKFRPFLLFGSAPLMLFSVLVFCVPAEWSHSNKVIYAYLTYMGLG
HHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHH
FCYSMVNIPYGSLATAMTQEPRSRARLGAARSIAASLTFVCLAFLIGPRITHSSPTEMAS
HHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VYLFWTIILAIAGMALYFICFKSTRENVVRIVAQPSLKISLQTLKQNRPLMMLCTGALCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCEEEHHHHHHHH
LISTFAVSASSLFYVRYVLNDTALFSVIVLVQMLVGSVASAPLVPRLVAKIGKKNTFLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
ALMGTLGYLLFFYMSDHSVPVALTALAIAAIGQGITMTVMWALEADTVEYGEYLTGVRIE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCEEEC
GLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQTQTPEVITGIRMSISLIPCGFMLLA
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FIIIWFYPLTDNKFKEIVQEIDKRKQSQQQLIKDFNK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; Glucuronides [Periplasm] [C]

Specific reaction: Proton [Periplasm] + Glucuronides [Periplasm] = Proton [Cytoplasm] + Glucuronides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3534890 [H]