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The map label for this gene is mdtL [H]

Identifier: 194734845

GI number: 194734845

Start: 3930088

End: 3931275

Strand: Direct

Name: mdtL [H]

Synonym: SeSA_A4056

Alternate gene names: 194734845

Gene position: 3930088-3931275 (Clockwise)

Preceding gene: 194736496

Following gene: 194737931

Centisome position: 83.46

GC content: 55.72

Gene sequence:

>1188_bases
ATGAAACGTTTTCTACTGTGTAGTTTTGCCCTGGTTTTACTCTATCCTGCCGGTATTGATATGTATCTGGTCGGTTTACC
GCGTATAGCCGCCGATCTGAACGCCAGCGAGGCGCAGTTGCATATCGCCTTCTCCGTTTACCTGGCCGGAATGGCGACGG
CCATGCTGTTTGCCGGGAAGATAGCCGACCAGTCAGGCCGCAAGCCGGTCGCGATCGTCGGCGCGCTCGTCTTTATGACG
GCCTCACTGCTTTGTTCACGGGCGTCGGAAGGCTCGCTATTTCTGAGTGGGCGTTTTCTTCAGGGGGTAGGAGCAGGCGG
CTGCTATGTGGTGGCGTTCGCCATTCTGCGCGACACGCTCGACGAGCATCGTCGGGCGAAAGTGCTGTCATTATTGAATG
GGATTACCTGTATTGTGCCGGTACTCGCCCCGGTGATGGGGCATTTGATTATGCTTCGTTTCCCCTGGCAAAGTCTGTTC
TATACGATGTCCGCGATGGGCATTATTGTGGGCCTGTTATCACTGTTTATCCTGCGCGAGACGCGCCCGGCAAGGCTGGC
TCCACGCGATTTATCACGATCGTCGCCCGCCGCCGAGTCGCTGGTTAACCGTTTTTTCGTCAGTCGACTGGCGATCACCA
CCCTTAGCGTGTCGGTGATCCTGACCTTCGTCAATGCCTCTCCAGTGCTGCTGATGGAGGTGATGGGATTTAGCCGTGGC
GACTATGCCATTACCATGGCGCTCACCGCAGGCGTCAGCATGGTCGTCTCTTTTTCTACCCCTTTTGCGCTTGGGTTATT
TAAGCCGCGAACCTTAATGCTCGTCTCACAGGGGCTGTTTTTGACGGCTGGCGTGACGTTAAGCCTTGCTCATACCAATA
CCGTCACGCTCTTTGGCCTGACGCTTATCTGCGCCGGATTCTCGGTTGGTTTTGGCGTCGCGATGAGCCAGGCGCTGGGG
CCGTTTTCGCTGCGCGCCGGAGTGGCCAGTTCCACGCTGGGTATCGCGCAGGTTTGCGGTTCATCACTGTGGATTTGGCT
GGCGGCAATACTCGGTATCAGCGCGATGAATATGCTGATCGGGATTCTGATTGGTTGTAGCATAGTGAGTATTCTGCTGA
TCTTCTCCGTCACGCCCAACAGGTCCGTAGCCGAGCATGAAGAAATCCCTTACCAATCTCGATCTTAA

Upstream 100 bases:

>100_bases
GCAATGATTTCCCATGCGGAAATCACTGTTGTCCAAATGGCAACTCGTCTCGCGCAACGTCGCCCCGTATTCTTAGCGCC
ACACTTTTCGTGAGGCCGCT

Downstream 100 bases:

>100_bases
TCTGCTGTTATGCCTACAGTTACTCATGCAGGAGCGCAGCGTCACTAAAGCTGCAAAACGGATGAACGTAACACCCTCTG
CGGTCAGCAAATCGCTGGCG

Product: multidrug efflux system protein MdtL

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMT
ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVMGHLIMLRFPWQSLF
YTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRG
DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALG
PFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRS

Sequences:

>Translated_395_residues
MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMT
ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVMGHLIMLRFPWQSLF
YTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRG
DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALG
PFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRS
>Mature_395_residues
MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMT
ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVMGHLIMLRFPWQSLF
YTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRG
DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALG
PFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=393, Percent_Identity=78.117048346056, Blast_Score=610, Evalue=1e-176,
Organism=Escherichia coli, GI1788509, Length=241, Percent_Identity=27.3858921161826, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994889, Length=237, Percent_Identity=28.6919831223629, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790794, Length=245, Percent_Identity=26.9387755102041, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082312, Length=345, Percent_Identity=28.1159420289855, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787065, Length=237, Percent_Identity=25.3164556962025, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41978; Mature: 41978

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGK
CCHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHHHH
IADQSGRKPVAIVGALVFMTASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTL
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHH
DEHRRAKVLSLLNGITCIVPVLAPVMGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
TRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRG
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGL
CEEEEEEHHHCHHHEEEECCCCEECCCCCCEEEHHHCCCEEEECCEEEEECCCHHHHHHH
TLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLI
HHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRS
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGK
CCHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHHHH
IADQSGRKPVAIVGALVFMTASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTL
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHH
DEHRRAKVLSLLNGITCIVPVLAPVMGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
TRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRG
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGL
CEEEEEEHHHCHHHEEEECCCCEECCCCCCEEEHHHCCCEEEECCEEEEECCCHHHHHHH
TLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLI
HHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GILIGCSIVSILLIFSVTPNRSVAEHEEIPYQSRS
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA