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The map label for this gene is uhpB [H]

Identifier: 194734624

GI number: 194734624

Start: 3870764

End: 3872266

Strand: Reverse

Name: uhpB [H]

Synonym: SeSA_A3999

Alternate gene names: 194734624

Gene position: 3872266-3870764 (Counterclockwise)

Preceding gene: 194738248

Following gene: 194737383

Centisome position: 82.23

GC content: 61.34

Gene sequence:

>1503_bases
ATGAACACCTTTTTTTCCCGTTTAATCACCGTTGTTGCCTGTTTTTTTATTTTCTCCGCCGCGTGGTTCTGCCTGTGGAG
CATCAGCCTGCATCTGGTAGAGCGCCCGGAGCTGGCGGCGCTGCTCTTTCCCTTCGGCCTGCGCCTGGGACTTATGCTGC
AATGTCCGCGCGGATACTGGCCAGTATTGCTGGGCGCGGAGTGGCTGCTGGTGTACTGGTTAGCGCAGGAAGTTGCGCTG
GCCCATCTGCCGCTTTTGATGATCGGTAGTGTGTTGACGCTACTGCCCGTGGCGCTGACTTCGCGTTACCGCCATCAGCG
CGACTGGCGCACGTTATTGCTTCAGGGCGCGGCCCTCACCGCCGCGGCGCTACTGCAATCCCTGCCCTGGTTGGGGCAGG
GGGAAGCGGCATGGAACGCGCTACTGCTGACCCTCACGGGTGGTCTGACGCTGGCCCCCATCTGCCTGGTTTTCTGGCAC
TATCTCACCAGCACTACCTGGCTGCCGCTGGGACCATCGCTGGTATCGCAGCCGGTAAACTGGCGCGGGCGGCATCTGAT
CTGGTATCTGCTGCTGTTTATCGTCAGTCTGTGGCTGCAACTGGGTTTACCTGCTGAACTTTCGCGCTTCACGCCGTTCT
GCCTGGCATTGCCGATTATCGCGCTCGCCTGGCATTATGGCTGGCAGGGCGCGCTCATTGCCACGCTGATGAATGCTATC
GCGCTGATCGCCAGCCAGACCTGGCACGATCATCCCGTCGATTTATTACTTTCGCTGTTGGTGCAAAGCCTGACCGGGCT
ACTGCTTGGCGCTGGCATTCAGCGTCTGCGCGAGCTGAACCAGTCGTTGCAAAAGGAGCTGGCGCGCAACCATCGGCTGG
CGGAGCGTCTTCTGGAGACCGAAGAGAGCGTGCGGCGCGATGTTGCGCGTGAGCTGCACGATGACATCGGGCAGACCATC
ACCGCGATTCGAACCCAGGCGGGCATTGTGCAACGACTGGCGGCGGATAACGGCGGCGTGAAGCAGAGCGGGCAACTTAT
CGAGCAGCTTTCGCTGGGCGTGTATGACGCCGTGCGTCGCCTGCTGGGGCGCTTGCGCCCGCGCCAGCTAGACGACTTAA
CGCTGGCGCAGGCCATCCGTTCGCTGCTGCGCGAAATGGAGCTGGAAAGCCGCGGTATTGTCAGTCACCTCGACTGGCGA
ATTGACGAAACGGCGCTGAGTGAAAGTCAGCGCGTGACGCTGTTTCGCGTCTGTCAGGAAGGGCTGAATAACATCGTAAA
ACATGCCAATGCCAGCGCGGTGACGCTCCAGGGCTGGCAGCAGGATGAGCGGCTGATGTTGGTGATTGAGGATGACGGCA
GCGGCCTGCCGCCGGGCTCTCAGCAGCAGGGCTTCGGCCTGACCGGAATGCGCGAACGCGTGTCGGCGCTCGGCGGGACG
CTAACCATCTCTTGTACCCACGGTACGCGGGTGAGCGTCTCGTTGCCCCAGCGTTACGTTTAA

Upstream 100 bases:

>100_bases
TGTCGCCAAAAACGGTGCATGTCCATCGCGCGAATCTGCTGGAAAAATTAGGCGTCAGCAATGACGTTGAACTGGCGCAT
CGCATGTTTGACGGTTGGTA

Downstream 100 bases:

>100_bases
GGAAGGATAATGCTTTCGTTTTTAAAAGCCCCGGCCAACGCGCCGCTCATCACCGATAAGCACGAGGTTGACGCCCGCTA
TCGCTACTGGCGGCGGCACA

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNTFFSRLITVVACFFIFSAAWFCLWSISLHLVERPELAALLFPFGLRLGLMLQCPRGYWPVLLGAEWLLVYWLAQEVAL
AHLPLLMIGSVLTLLPVALTSRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEAAWNALLLTLTGGLTLAPICLVFWH
YLTSTTWLPLGPSLVSQPVNWRGRHLIWYLLLFIVSLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNHRLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNGGVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLAQAIRSLLREMELESRGIVSHLDWR
IDETALSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSQQQGFGLTGMRERVSALGGT
LTISCTHGTRVSVSLPQRYV

Sequences:

>Translated_500_residues
MNTFFSRLITVVACFFIFSAAWFCLWSISLHLVERPELAALLFPFGLRLGLMLQCPRGYWPVLLGAEWLLVYWLAQEVAL
AHLPLLMIGSVLTLLPVALTSRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEAAWNALLLTLTGGLTLAPICLVFWH
YLTSTTWLPLGPSLVSQPVNWRGRHLIWYLLLFIVSLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNHRLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNGGVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLAQAIRSLLREMELESRGIVSHLDWR
IDETALSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSQQQGFGLTGMRERVSALGGT
LTISCTHGTRVSVSLPQRYV
>Mature_500_residues
MNTFFSRLITVVACFFIFSAAWFCLWSISLHLVERPELAALLFPFGLRLGLMLQCPRGYWPVLLGAEWLLVYWLAQEVAL
AHLPLLMIGSVLTLLPVALTSRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEAAWNALLLTLTGGLTLAPICLVFWH
YLTSTTWLPLGPSLVSQPVNWRGRHLIWYLLLFIVSLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNHRLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNGGVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLAQAIRSLLREMELESRGIVSHLDWR
IDETALSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSQQQGFGLTGMRERVSALGGT
LTISCTHGTRVSVSLPQRYV

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=500, Percent_Identity=91.4, Blast_Score=816, Evalue=0.0,
Organism=Escherichia coli, GI1788812, Length=210, Percent_Identity=32.8571428571429, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787474, Length=219, Percent_Identity=26.9406392694064, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55853; Mature: 55853

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFFSRLITVVACFFIFSAAWFCLWSISLHLVERPELAALLFPFGLRLGLMLQCPRGYW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCC
PVLLGAEWLLVYWLAQEVALAHLPLLMIGSVLTLLPVALTSRYRHQRDWRTLLLQGAALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLQSLPWLGQGEAAWNALLLTLTGGLTLAPICLVFWHYLTSTTWLPLGPSLVSQPVN
HHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
WRGRHLIWYLLLFIVSLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNHRLAERLLET
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNGGVKQSGQLIEQLSLGVYDAVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLTLAQAIRSLLREMELESRGIVSHLDWRIDETALSESQRVTLFRVCQE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCHHHHHHHHHHH
GLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSQQQGFGLTGMRERVSALGGT
HHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
LTISCTHGTRVSVSLPQRYV
EEEEECCCCEEEECCCCCCC
>Mature Secondary Structure
MNTFFSRLITVVACFFIFSAAWFCLWSISLHLVERPELAALLFPFGLRLGLMLQCPRGYW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCC
PVLLGAEWLLVYWLAQEVALAHLPLLMIGSVLTLLPVALTSRYRHQRDWRTLLLQGAALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLQSLPWLGQGEAAWNALLLTLTGGLTLAPICLVFWHYLTSTTWLPLGPSLVSQPVN
HHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
WRGRHLIWYLLLFIVSLWLQLGLPAELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNHRLAERLLET
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNGGVKQSGQLIEQLSLGVYDAVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLTLAQAIRSLLREMELESRGIVSHLDWRIDETALSESQRVTLFRVCQE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCHHHHHHHHHHH
GLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSQQQGFGLTGMRERVSALGGT
HHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
LTISCTHGTRVSVSLPQRYV
EEEEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]