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The map label for this gene is uhpA [H]

Identifier: 194738248

GI number: 194738248

Start: 3872266

End: 3872856

Strand: Reverse

Name: uhpA [H]

Synonym: SeSA_A4000

Alternate gene names: 194738248

Gene position: 3872856-3872266 (Counterclockwise)

Preceding gene: 194737627

Following gene: 194734624

Centisome position: 82.24

GC content: 58.88

Gene sequence:

>591_bases
ATGATTACCGTTGCCCTTATCGACGACCACCTTATCGTCCGCTCCGGCTTTGCACAGCTACTGGGGCTGGAACCTGATTT
GCAGGTGGTCGCCGAATTTGGTTCCGGGCGCGAAGCGTTGGCAGGCTTACCGGGGCGCGGCGTACAGGTGTGTATCTGCG
ATATCTCGATGCCGGATATTTCCGGACTGGAGCTGCTAAGCCAACTGCCAAAAGGGATGGCGACGATCATGCTCTCGGTT
CACGATAGCCCGGCGCTGGTGGAACAGGCGTTGAACGCCGGCGCGCGCGGTTTCCTCTCTAAACGCTGTAGTCCGGATGA
ACTGATCGCCGCGGTGCATACGGTGGCGACGGGCGGCTGCTATTTGACCCCCGATATTGCCGTGAAACTGGCGGCGGGTC
GGCAAGATCCGCTGACCAAACGCGAGCGTCAGGTGGCGGAAAAACTCGCCCAGGGTATGGCGGTAAAAGAGATTGCCGCC
GAGCTGGGGCTGTCGCCAAAAACGGTGCATGTCCATCGCGCGAATCTGCTGGAAAAATTAGGCGTCAGCAATGACGTTGA
ACTGGCGCATCGCATGTTTGACGGTTGGTAA

Upstream 100 bases:

>100_bases
GGATGGCGGCATTAATGCCTTATCCGGCCTACAACGGCACCTGCCCGTAGGCCTGATAAGCGCAGCGCCATCAGGCATGC
CTTAGCGTCAGGATGAACCC

Downstream 100 bases:

>100_bases
TGAACACCTTTTTTTCCCGTTTAATCACCGTTGTTGCCTGTTTTTTTATTTTCTCCGCCGCGTGGTTCTGCCTGTGGAGC
ATCAGCCTGCATCTGGTAGA

Product: DNA-binding transcriptional activator UhpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAVKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLLEKLGVSNDVELAHRMFDGW

Sequences:

>Translated_196_residues
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAVKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLLEKLGVSNDVELAHRMFDGW
>Mature_196_residues
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAVKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLLEKLGVSNDVELAHRMFDGW

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=97.9591836734694, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1788222, Length=202, Percent_Identity=36.6336633663366, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=36.5979381443299, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=34.4262295081967, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1786747, Length=196, Percent_Identity=29.0816326530612, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1788712, Length=183, Percent_Identity=27.8688524590164, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=29.064039408867, Blast_Score=77, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 20823; Mature: 20823

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDI
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCC
SGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGC
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCE
YLTPDIAVKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLLEKL
EECHHHEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEHHHHHHHHHH
GVSNDVELAHRMFDGW
CCCCHHHHHHHHHCCC
>Mature Secondary Structure
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDI
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCC
SGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGC
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCE
YLTPDIAVKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLLEKL
EECHHHEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEHHHHHHHHHH
GVSNDVELAHRMFDGW
CCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]