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The map label for this gene is pipB2 [H]

Identifier: 194734353

GI number: 194734353

Start: 2833929

End: 2835029

Strand: Reverse

Name: pipB2 [H]

Synonym: SeSA_A2921

Alternate gene names: 194734353

Gene position: 2835029-2833929 (Counterclockwise)

Preceding gene: 194734446

Following gene: 194736057

Centisome position: 60.2

GC content: 43.6

Gene sequence:

>1101_bases
ATGATAAATTTTATCATGTACTGTGTTGCTCTCTCTGGGAGAAAATATATGCAGCGTTCACTCGGTAGTCTGGCCGGTAT
GGCTACATCTGCTTTTGGCGCGGGGACTTCTGCTGCTATGCGGCAAGCCACCTCTCCCAAAACTATTCTGGAACATATCA
TTAACTTTTTTACCTGTGGTGGGGTGCGTCGGAAAAATGAAGCACAATATCAGGAATTGATAGACACTATGGCTGATACA
TTGAAAAGTTCAATGTCTGACAGAGGTGCTCCGTTGCCAGAAAACATCATACTGGAGGATATGGATGGGTGTCGTGTCGA
ATTTAATCTTCCTGGTGAGAATAACGAAGCTGGACAAGTTATTGTACGAGTCAGTAAAGGCGACCATTCTGAGACAAGAG
AAATTCCGCTTGTCTCTTTTGAAAAAATATGTCGAGCTTTACTATTCAGATGCGAATTTTCTCTTCCTCAGGATTCTGTA
ATATTAACTGCCCAGGGAGGCATGAATCTTAAAGGCGCTGTCCTTACCGGAGCAAATCTGACGGCAGAAAATTTATGTGA
CGCAGACTTAAGCGGCGCAGATTTAGAGGGGGCAATACTGTTTATGGCGGATTGTGACGGTGCAAATTTTAAGGGCGCAA
ATCTATCGGGAGCATCATTAGGCGACAGTAACTTAACGAACGCCTGTCTGGAAGATAGTATTATGTGTGGCGCTACCCTC
GATCGCGCTAATCTTACTGGCGCCAATTTACAACACACAAGTCTGTTAGGCTGTAGCATGGTAGAATGTAATTGTTCCGG
TGCGAATATGGATCACGCTAATGTTTCAGGCTCAACCCTTATACGTGCCGATATGAGCGGTGCGACATTAAAGGGTGCTA
CTATAATGGCTGCTATTATGGAAGGCGCTGTCTTAACTCGGGCAAACCTGCAAAAGGCTAGTTTTACTGCTACGAACCTG
GACGGGGCTGATTTGTCTGAGGCTAATTTAAGAAATACCAGTTTTAAAGATTGTACACTAACCGATTTGCGTACCGAAGA
CGCCACAATGTCTACAAGTACACAAACACTTTTTAACGTATTTTATAGTGAAAATATTTAG

Upstream 100 bases:

>100_bases
TGGCTGATATTGTGTAAGTCAGACAGCAAAGCACCGTGATACGTGATTATGTAACCAGACGCAAAGGGGGTATTCACCTT
ATCTCTAAATGCAAATCTAT

Downstream 100 bases:

>100_bases
CCCTATTTGACGTAAATCTGAAATAAAAGCAATGTAAGAATGACAATGTGCTACTGAATAGTAGCTGAGAGTAAATTATT
TACAGTATCTTTTATTATTA

Product: effector protein pipB2

Products: NA

Alternate protein names: Type III effector pipB2 [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MINFIMYCVALSGRKYMQRSLGSLAGMATSAFGAGTSAAMRQATSPKTILEHIINFFTCGGVRRKNEAQYQELIDTMADT
LKSSMSDRGAPLPENIILEDMDGCRVEFNLPGENNEAGQVIVRVSKGDHSETREIPLVSFEKICRALLFRCEFSLPQDSV
ILTAQGGMNLKGAVLTGANLTAENLCDADLSGADLEGAILFMADCDGANFKGANLSGASLGDSNLTNACLEDSIMCGATL
DRANLTGANLQHTSLLGCSMVECNCSGANMDHANVSGSTLIRADMSGATLKGATIMAAIMEGAVLTRANLQKASFTATNL
DGADLSEANLRNTSFKDCTLTDLRTEDATMSTSTQTLFNVFYSENI

Sequences:

>Translated_366_residues
MINFIMYCVALSGRKYMQRSLGSLAGMATSAFGAGTSAAMRQATSPKTILEHIINFFTCGGVRRKNEAQYQELIDTMADT
LKSSMSDRGAPLPENIILEDMDGCRVEFNLPGENNEAGQVIVRVSKGDHSETREIPLVSFEKICRALLFRCEFSLPQDSV
ILTAQGGMNLKGAVLTGANLTAENLCDADLSGADLEGAILFMADCDGANFKGANLSGASLGDSNLTNACLEDSIMCGATL
DRANLTGANLQHTSLLGCSMVECNCSGANMDHANVSGSTLIRADMSGATLKGATIMAAIMEGAVLTRANLQKASFTATNL
DGADLSEANLRNTSFKDCTLTDLRTEDATMSTSTQTLFNVFYSENI
>Mature_366_residues
MINFIMYCVALSGRKYMQRSLGSLAGMATSAFGAGTSAAMRQATSPKTILEHIINFFTCGGVRRKNEAQYQELIDTMADT
LKSSMSDRGAPLPENIILEDMDGCRVEFNLPGENNEAGQVIVRVSKGDHSETREIPLVSFEKICRALLFRCEFSLPQDSV
ILTAQGGMNLKGAVLTGANLTAENLCDADLSGADLEGAILFMADCDGANFKGANLSGASLGDSNLTNACLEDSIMCGATL
DRANLTGANLQHTSLLGCSMVECNCSGANMDHANVSGSTLIRADMSGATLKGATIMAAIMEGAVLTRANLQKASFTATNL
DGADLSEANLRNTSFKDCTLTDLRTEDATMSTSTQTLFNVFYSENI

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the

COG id: COG1357

COG function: function code S; Uncharacterized low-complexity proteins

Gene ontology:

Cell location: Secreted. Host membrane (By similarity). Note=Secreted via the type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell (By similarity) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 pentapeptide repeat domains [H]

Homologues:

Organism=Homo sapiens, GI39753959, Length=159, Percent_Identity=34.5911949685535, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221377802, Length=157, Percent_Identity=35.031847133758, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001646 [H]

Pfam domain/function: PF00805 Pentapeptide [H]

EC number: NA

Molecular weight: Translated: 38828; Mature: 38828

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINFIMYCVALSGRKYMQRSLGSLAGMATSAFGAGTSAAMRQATSPKTILEHIINFFTCG
CHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHCC
GVRRKNEAQYQELIDTMADTLKSSMSDRGAPLPENIILEDMDGCRVEFNLPGENNEAGQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEE
IVRVSKGDHSETREIPLVSFEKICRALLFRCEFSLPQDSVILTAQGGMNLKGAVLTGANL
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCC
TAENLCDADLSGADLEGAILFMADCDGANFKGANLSGASLGDSNLTNACLEDSIMCGATL
CHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCEE
DRANLTGANLQHTSLLGCSMVECNCSGANMDHANVSGSTLIRADMSGATLKGATIMAAIM
CCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHH
EGAVLTRANLQKASFTATNLDGADLSEANLRNTSFKDCTLTDLRTEDATMSTSTQTLFNV
HCHHEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHH
FYSENI
HHHCCC
>Mature Secondary Structure
MINFIMYCVALSGRKYMQRSLGSLAGMATSAFGAGTSAAMRQATSPKTILEHIINFFTCG
CHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHCC
GVRRKNEAQYQELIDTMADTLKSSMSDRGAPLPENIILEDMDGCRVEFNLPGENNEAGQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEE
IVRVSKGDHSETREIPLVSFEKICRALLFRCEFSLPQDSVILTAQGGMNLKGAVLTGANL
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCC
TAENLCDADLSGADLEGAILFMADCDGANFKGANLSGASLGDSNLTNACLEDSIMCGATL
CHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCEE
DRANLTGANLQHTSLLGCSMVECNCSGANMDHANVSGSTLIRADMSGATLKGATIMAAIM
CCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHH
EGAVLTRANLQKASFTATNLDGADLSEANLRNTSFKDCTLTDLRTEDATMSTSTQTLFNV
HCHHEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHH
FYSENI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA