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The map label for this gene is gyrI

Identifier: 194734276

GI number: 194734276

Start: 2115132

End: 2115599

Strand: Reverse

Name: gyrI

Synonym: SeSA_A2231

Alternate gene names: 194734276

Gene position: 2115599-2115132 (Counterclockwise)

Preceding gene: 194734763

Following gene: 194737991

Centisome position: 44.93

GC content: 50.64

Gene sequence:

>468_bases
ATGGATTACGAAATCAGGCAGGAACAAAAACGCAAGATAGCCGGTTTCCACATGGTCGGTCCATGGGAACACACCGTGAA
GCAGGGTTTTGAACAACTGATGACGTGGGTGGATCGACAGCGGATCGTGCCAGTTGAATGGATTGCCGTCTATTACGACA
ATCCAGATGTCGTACCTGCAGAAAAACTCCGCTGCGATACCGTGGTGTCCGTGGCAGAGAATTTCATCCTGCCGGACAAT
AGTGAAGGCGTAATCGTGACCGCCATTGAAGGCGGCGAATATGCCACTGCTGTCGCGCGAGTGGAAGACCGTGACTTTGC
GAAGCCGTGGGAACGGTTTTTTGACGTCCTGGAGCAGGATAGCGCTTATCAGATAGCCTCTGCGCCCTGTTTTGAAACCT
ATCTGAATAACGGTATGGAAGATGGATACTGGGATATTGAAATGTATATTCCGGTACAGCGGAAGTGA

Upstream 100 bases:

>100_bases
TTGCGAGGTTGCTCACAAAATGATCACGCTGTCCTTGTGACCGTAAAATGCTGTAATTATACTGTACATTCATACAGTAT
GGTAAAGTGACGGAGGCAGC

Downstream 100 bases:

>100_bases
TCGACTGGTTTCCTGGCTGAAAAGAGCGGACGGATAATGTGTTCCGTCCGCCAGTGCGCTATTTTTGCTATAAAGCAGGT
ACAATGCATTTTTTGCCATT

Product: DNA gyrase inhibitor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MDYEIRQEQKRKIAGFHMVGPWEHTVKQGFEQLMTWVDRQRIVPVEWIAVYYDNPDVVPAEKLRCDTVVSVAENFILPDN
SEGVIVTAIEGGEYATAVARVEDRDFAKPWERFFDVLEQDSAYQIASAPCFETYLNNGMEDGYWDIEMYIPVQRK

Sequences:

>Translated_155_residues
MDYEIRQEQKRKIAGFHMVGPWEHTVKQGFEQLMTWVDRQRIVPVEWIAVYYDNPDVVPAEKLRCDTVVSVAENFILPDN
SEGVIVTAIEGGEYATAVARVEDRDFAKPWERFFDVLEQDSAYQIASAPCFETYLNNGMEDGYWDIEMYIPVQRK
>Mature_155_residues
MDYEIRQEQKRKIAGFHMVGPWEHTVKQGFEQLMTWVDRQRIVPVEWIAVYYDNPDVVPAEKLRCDTVVSVAENFILPDN
SEGVIVTAIEGGEYATAVARVEDRDFAKPWERFFDVLEQDSAYQIASAPCFETYLNNGMEDGYWDIEMYIPVQRK

Specific function: Inhibits the supercoiling activity of DNA gyrase. Protects cells from the DNA replication inhibitor microcin B17 (MccB17). Blocks MccB17 export from producing cells

COG id: COG3449

COG function: function code L; DNA gyrase inhibitor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788319, Length=155, Percent_Identity=70.9677419354839, Blast_Score=238, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GYRI_SALTI (P0A213)

Other databases:

- EMBL:   AL627273
- EMBL:   AE014613
- RefSeq:   NP_456610.1
- RefSeq:   NP_804653.1
- ProteinModelPortal:   P0A213
- SMR:   P0A213
- GeneID:   1070084
- GeneID:   1248604
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t0813
- KEGG:   sty:STY2266
- HOGENOM:   HBG417284
- OMA:   IAGFHLV
- ProtClustDB:   PRK10016
- BioCyc:   SENT209261:T0813-MONOMER
- BioCyc:   SENT220341:STY2266-MONOMER
- GO:   GO:0005737
- InterPro:   IPR010499
- InterPro:   IPR011256
- SMART:   SM00871

Pfam domain/function: PF06445 AraC_E_bind; SSF55136 Bac_reg_effector

EC number: NA

Molecular weight: Translated: 18062; Mature: 18062

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEIRQEQKRKIAGFHMVGPWEHTVKQGFEQLMTWVDRQRIVPVEWIAVYYDNPDVVPA
CCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCH
EKLRCDTVVSVAENFILPDNSEGVIVTAIEGGEYATAVARVEDRDFAKPWERFFDVLEQD
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEHEECCCCCCCHHHHHHHHHHHCCC
SAYQIASAPCFETYLNNGMEDGYWDIEMYIPVQRK
CCEEECCCCHHHHHHCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MDYEIRQEQKRKIAGFHMVGPWEHTVKQGFEQLMTWVDRQRIVPVEWIAVYYDNPDVVPA
CCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCH
EKLRCDTVVSVAENFILPDNSEGVIVTAIEGGEYATAVARVEDRDFAKPWERFFDVLEQD
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEHEECCCCCCCHHHHHHHHHHHCCC
SAYQIASAPCFETYLNNGMEDGYWDIEMYIPVQRK
CCEEECCCCHHHHHHCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504