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The map label for this gene is ygcA [C]

Identifier: 194335110

GI number: 194335110

Start: 2506763

End: 2508199

Strand: Reverse

Name: ygcA [C]

Synonym: Paes_2332

Alternate gene names: 194335110

Gene position: 2508199-2506763 (Counterclockwise)

Preceding gene: 194335111

Following gene: 194335108

Centisome position: 99.81

GC content: 55.81

Gene sequence:

>1437_bases
ATGACATTACGTGACATCTACCGTAAGGGAGAGCTGGTCGAACTTACGATTGCAGATATAGCAGAAAAAGATCAGTGTTT
CGGCACGCTCGACAACGGGGCAGGGGTGCTTGTCCGGGGAATGCTGGCTGTGGGCGACAGGGTCTCGGCCAAGGTGCTCA
AAGTCAAACCGCGCTATCTCGAGGCGGTGCTCGATGAGCTGCTGGAGCCATCGGAAGACAGGGTCGAACCGGTATGCTCG
GTCTTCGGCGTGTGTGGCGGATGCAAATGGATGCATGTCAGCTATGATGCCCAGCTGCACTATAAGAAAAAGAAAGTTGC
CGATGCGCTTGAGCACATCGGCGGCATGCACGACATTGCCGTTCAACCGGTTCTTCCTGCACCGGAGGCCTTTCACTATC
GCAACAAGGTGGAGTTCTCATGCTCCAGCAAGCGCTATCTGCTGCCTCATGAGCTTTCCATGGAGACATTGGACAAATCC
AAAGACTTCGCATTGGGCTTTCATGCCCCGGGGAACTTCGAGAAAGTGCTCGAAATCGACACCTGTTATCTTGCCAAACC
CAGTATGAACGAAGCGCTTTCGGCGACAAGAGCGTTTGCGCTTGATCGGGGGCTTGAACCCTATGCAGCCCGCGCGCACA
CAGGGTTTCTCCGTAACCTCATGCTTCGTTACAGTGAAGAGCATGACGAGCTGATGGTCAATATTGTCACCTCATGGTAT
GACCGGGAGCTGATGGAGGCGTATCGGGACCATCTGCTCGAACGCATGAAGGGCCGACGAATGACCATTGTCAATAATGT
CACCACACGCAAGAATACCGTCTCGACCGGAGAGAAAGAGTATGTCGTCTACGGGGACGGGACTCTTCGCGAAAGGCTGG
GCGACCTGCACTTCCGGATCTCGGCAAACTCCTTTTTCCAGACCAATACCCGACAGGCCGAAGCGCTCTACGAGGGAATT
ATGCGCATGGCCGGGCTGAAGCAGGACGATGTTGTCTATGATCTCTACTGCGGTACCGGGACGATCACGCTCTACCTTGC
CGAACGATGCCGTCAGGCGGTAGGTCTCGAAGTGGTCGAGAGCTCGATCATCGATGCTGCTGAAAATGCCGGGGCGAACG
GGATTGAAAACGCAGCGTTCTATCAGGTCGATCTGAAGGACTTTCACACCCTGGTCCCGACCCTTGAGCAGTATGGCATG
CCGAGAGTTATTGTCACCGATCCTCCGCGTGCGGGCATGCATCCCAAAGCGCTTGAAACCCTGCTCCGCCTCCAGCCGGA
GACCATTGTCTACGTCAGCTGCAACCCGGCCAACCTTGCGCGCGACGGTAAGGAGATCGTACAGCAAGGTTACAGGCTTG
AAGAGGTTCAGCCGGTCGACATGTTCCCGCACACCAGCCATGTGGAGACGCTGGCGTGCTTCCGACGAACGGTGTGA

Upstream 100 bases:

>100_bases
ATCATTCGATACGCCTGTCGTCCGCCCCCGGCTTGGCGACAGTGCCGGAGTTTTCGGGGCAGCATTGCTGACAGCGTACT
AACAGGAAAAAAGAAGAATA

Downstream 100 bases:

>100_bases
GCTGGTTGTTGCATCATTGATTTTTTGCCTTGTCAAAGCCGCCTTTTCAGGCGGCTTTGTCCGTTATCATTCAACGCTCA
TCGCAGACGACGGTAACTCT

Product: RNA methyltransferase, TrmA family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTLRDIYRKGELVELTIADIAEKDQCFGTLDNGAGVLVRGMLAVGDRVSAKVLKVKPRYLEAVLDELLEPSEDRVEPVCS
VFGVCGGCKWMHVSYDAQLHYKKKKVADALEHIGGMHDIAVQPVLPAPEAFHYRNKVEFSCSSKRYLLPHELSMETLDKS
KDFALGFHAPGNFEKVLEIDTCYLAKPSMNEALSATRAFALDRGLEPYAARAHTGFLRNLMLRYSEEHDELMVNIVTSWY
DRELMEAYRDHLLERMKGRRMTIVNNVTTRKNTVSTGEKEYVVYGDGTLRERLGDLHFRISANSFFQTNTRQAEALYEGI
MRMAGLKQDDVVYDLYCGTGTITLYLAERCRQAVGLEVVESSIIDAAENAGANGIENAAFYQVDLKDFHTLVPTLEQYGM
PRVIVTDPPRAGMHPKALETLLRLQPETIVYVSCNPANLARDGKEIVQQGYRLEEVQPVDMFPHTSHVETLACFRRTV

Sequences:

>Translated_478_residues
MTLRDIYRKGELVELTIADIAEKDQCFGTLDNGAGVLVRGMLAVGDRVSAKVLKVKPRYLEAVLDELLEPSEDRVEPVCS
VFGVCGGCKWMHVSYDAQLHYKKKKVADALEHIGGMHDIAVQPVLPAPEAFHYRNKVEFSCSSKRYLLPHELSMETLDKS
KDFALGFHAPGNFEKVLEIDTCYLAKPSMNEALSATRAFALDRGLEPYAARAHTGFLRNLMLRYSEEHDELMVNIVTSWY
DRELMEAYRDHLLERMKGRRMTIVNNVTTRKNTVSTGEKEYVVYGDGTLRERLGDLHFRISANSFFQTNTRQAEALYEGI
MRMAGLKQDDVVYDLYCGTGTITLYLAERCRQAVGLEVVESSIIDAAENAGANGIENAAFYQVDLKDFHTLVPTLEQYGM
PRVIVTDPPRAGMHPKALETLLRLQPETIVYVSCNPANLARDGKEIVQQGYRLEEVQPVDMFPHTSHVETLACFRRTV
>Mature_477_residues
TLRDIYRKGELVELTIADIAEKDQCFGTLDNGAGVLVRGMLAVGDRVSAKVLKVKPRYLEAVLDELLEPSEDRVEPVCSV
FGVCGGCKWMHVSYDAQLHYKKKKVADALEHIGGMHDIAVQPVLPAPEAFHYRNKVEFSCSSKRYLLPHELSMETLDKSK
DFALGFHAPGNFEKVLEIDTCYLAKPSMNEALSATRAFALDRGLEPYAARAHTGFLRNLMLRYSEEHDELMVNIVTSWYD
RELMEAYRDHLLERMKGRRMTIVNNVTTRKNTVSTGEKEYVVYGDGTLRERLGDLHFRISANSFFQTNTRQAEALYEGIM
RMAGLKQDDVVYDLYCGTGTITLYLAERCRQAVGLEVVESSIIDAAENAGANGIENAAFYQVDLKDFHTLVPTLEQYGMP
RVIVTDPPRAGMHPKALETLLRLQPETIVYVSCNPANLARDGKEIVQQGYRLEEVQPVDMFPHTSHVETLACFRRTV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=382, Percent_Identity=29.5811518324607, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI51173878, Length=382, Percent_Identity=29.5811518324607, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI269784680, Length=426, Percent_Identity=26.5258215962441, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI269784676, Length=426, Percent_Identity=26.5258215962441, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI20149688, Length=426, Percent_Identity=26.5258215962441, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI269784678, Length=210, Percent_Identity=31.9047619047619, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789148, Length=445, Percent_Identity=27.6404494382022, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1787083, Length=400, Percent_Identity=27.25, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790403, Length=238, Percent_Identity=25.6302521008403, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997438, Length=166, Percent_Identity=31.3253012048193, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24666579, Length=450, Percent_Identity=28.8888888888889, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 53915; Mature: 53784

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRDIYRKGELVELTIADIAEKDQCFGTLDNGAGVLVRGMLAVGDRVSAKVLKVKPRYL
CCHHHHHCCCCEEEEEHHHHCCHHHHCEECCCCCHHHHHHHHHHCCCCCCEEEEECHHHH
EAVLDELLEPSEDRVEPVCSVFGVCGGCKWMHVSYDAQLHYKKKKVADALEHIGGMHDIA
HHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHEE
VQPVLPAPEAFHYRNKVEFSCSSKRYLLPHELSMETLDKSKDFALGFHAPGNFEKVLEID
ECCCCCCCHHHHCCCCEEEEECCCCEECCCCCCHHHHCCCCCEEEEECCCCCHHHHEEEC
TCYLAKPSMNEALSATRAFALDRGLEPYAARAHTGFLRNLMLRYSEEHDELMVNIVTSWY
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
DRELMEAYRDHLLERMKGRRMTIVNNVTTRKNTVSTGEKEYVVYGDGTLRERLGDLHFRI
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCEEEEE
SANSFFQTNTRQAEALYEGIMRMAGLKQDDVVYDLYCGTGTITLYLAERCRQAVGLEVVE
ECCCEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHH
SSIIDAAENAGANGIENAAFYQVDLKDFHTLVPTLEQYGMPRVIVTDPPRAGMHPKALET
HHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
LLRLQPETIVYVSCNPANLARDGKEIVQQGYRLEEVQPVDMFPHTSHVETLACFRRTV
HHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TLRDIYRKGELVELTIADIAEKDQCFGTLDNGAGVLVRGMLAVGDRVSAKVLKVKPRYL
CHHHHHCCCCEEEEEHHHHCCHHHHCEECCCCCHHHHHHHHHHCCCCCCEEEEECHHHH
EAVLDELLEPSEDRVEPVCSVFGVCGGCKWMHVSYDAQLHYKKKKVADALEHIGGMHDIA
HHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHEE
VQPVLPAPEAFHYRNKVEFSCSSKRYLLPHELSMETLDKSKDFALGFHAPGNFEKVLEID
ECCCCCCCHHHHCCCCEEEEECCCCEECCCCCCHHHHCCCCCEEEEECCCCCHHHHEEEC
TCYLAKPSMNEALSATRAFALDRGLEPYAARAHTGFLRNLMLRYSEEHDELMVNIVTSWY
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
DRELMEAYRDHLLERMKGRRMTIVNNVTTRKNTVSTGEKEYVVYGDGTLRERLGDLHFRI
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCEEEEE
SANSFFQTNTRQAEALYEGIMRMAGLKQDDVVYDLYCGTGTITLYLAERCRQAVGLEVVE
ECCCEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHH
SSIIDAAENAGANGIENAAFYQVDLKDFHTLVPTLEQYGMPRVIVTDPPRAGMHPKALET
HHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
LLRLQPETIVYVSCNPANLARDGKEIVQQGYRLEEVQPVDMFPHTSHVETLACFRRTV
HHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]