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The map label for this gene is umuC [H]

Identifier: 194334989

GI number: 194334989

Start: 2373075

End: 2374349

Strand: Reverse

Name: umuC [H]

Synonym: Paes_2200

Alternate gene names: 194334989

Gene position: 2374349-2373075 (Counterclockwise)

Preceding gene: 194334990

Following gene: 194334987

Centisome position: 94.49

GC content: 59.45

Gene sequence:

>1275_bases
ATGTTCGCTCTGGTTGACTGCAATAATTTTTACGCTTCGTGCGAGCGGGTGTTCAATCCGGCGCTTGTCGGGCGGCCGGT
CGTTGTGCTGTCGAACAACGACGGGTGCGTTATTGCCCGTTCAGAGGAGGCGAAGGTCCTGGGGATCGGGATGGGCGCCC
CGGAGTTCAAGTGCCGCGAACTGCTGCTGCGCCACGGGGTTGCTGTCTTTTCATCCAACTATCCGCTCTATGGCGATATG
TCTTCGCGGGTGATGACGACGCTGGCAGGTTTTGCGCCGTCGATCGAGGTGTATTCGATCGACGAATCTTTTCTCGATCT
CAGCGGTTTCGGGCGCTTTGACCTTGAGCGCTACGGGAGCGAGATCCGAAGGACAGTACGGAGGCATACCGGTATTCCTG
TGGGGGTCGGGATTGCCGCAACCAAAACGCTTGCCAAGATTGCCAACCGGATTGCCAAGAAGCACCTGGAGTATGATGGG
GTATGCGTGCTTGAGCGCGATGCGGAGATTCAGCGTGCGCTGAAGCTGATCGCGGTTGGTGATATCTGGGGCGTCGGACG
GCAGTGGGCGAGTTTCCTGCAGACGAACGGTATTGGTACGGCAGCTGATTTTGCCGCTGCATCGCCCGCCTGGATCAGGC
AGCATATGCATGTGACCGGGGCACGGGTTCAGGCTGAGCTGAACGGGCACTCATGTCTGGCTCTGGAAGCGGTGAGGCCG
GTGAAGAAAAGCATCTGCACCTCCCGCTCGTTCGGGCGGACGGTGAGATCGAAAGAGGATCTGCGACAGGCGGTGGCGAC
CTTTGCCGGACGGTGCGCTCTCAAGCTGCGCCGTGAAGGTCTCCGAACTTCGCTTGTTACGGTCTTTGCCGCAACGAGCC
GTTTCAATCACGAGAGCGAGCGCTACTGGGGGACGAGAACTCTTGCTCTGCAGGAGCCGTCGCAGGATTCCATTGTCCTG
CTCAACGCCGCGGAGCAGCTGCTCGATGCACTCTATCAGCCCGGCTATGAGTACCGGAAAGCGGGCGTTCTCCTCGCCGG
TCTGAACCCTGCAGACGCTCCCGGAGCAGCGCTGTCACTGTTTCCTGAAGCTCCTTGCACTCGTGACGGGCAGCACCGTA
AACTCATGCAGATTATGGACGCCGTCAACCGGCGTTACGGCCACGGCACCATCCATCTCGCAGCAGAAGAGACCGAAGCA
TGGAAACCCCTGCAGAAACGGCTTTCGCCACGTTACACCACCCGGTGGTCGGAGATTCTGGAGGTTCATAGCTGA

Upstream 100 bases:

>100_bases
ATTTCAGCCTATCCGCATTACTGAAGAGAGCGATTTTCTTGTTTGGGGTATCGTGACCTTTATTGTGCATAAACCGAGAT
AGTCGGGAGAGGTATACGCC

Downstream 100 bases:

>100_bases
TTTTGCAAAAAAGCAGGGACATCCTATATTGAAACCACCAAAAACAATTTTTTCACGGTCGAAAATAATCCTGCCAAGTG
CCTCGAAAAGCACGTTACTG

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MFALVDCNNFYASCERVFNPALVGRPVVVLSNNDGCVIARSEEAKVLGIGMGAPEFKCRELLLRHGVAVFSSNYPLYGDM
SSRVMTTLAGFAPSIEVYSIDESFLDLSGFGRFDLERYGSEIRRTVRRHTGIPVGVGIAATKTLAKIANRIAKKHLEYDG
VCVLERDAEIQRALKLIAVGDIWGVGRQWASFLQTNGIGTAADFAAASPAWIRQHMHVTGARVQAELNGHSCLALEAVRP
VKKSICTSRSFGRTVRSKEDLRQAVATFAGRCALKLRREGLRTSLVTVFAATSRFNHESERYWGTRTLALQEPSQDSIVL
LNAAEQLLDALYQPGYEYRKAGVLLAGLNPADAPGAALSLFPEAPCTRDGQHRKLMQIMDAVNRRYGHGTIHLAAEETEA
WKPLQKRLSPRYTTRWSEILEVHS

Sequences:

>Translated_424_residues
MFALVDCNNFYASCERVFNPALVGRPVVVLSNNDGCVIARSEEAKVLGIGMGAPEFKCRELLLRHGVAVFSSNYPLYGDM
SSRVMTTLAGFAPSIEVYSIDESFLDLSGFGRFDLERYGSEIRRTVRRHTGIPVGVGIAATKTLAKIANRIAKKHLEYDG
VCVLERDAEIQRALKLIAVGDIWGVGRQWASFLQTNGIGTAADFAAASPAWIRQHMHVTGARVQAELNGHSCLALEAVRP
VKKSICTSRSFGRTVRSKEDLRQAVATFAGRCALKLRREGLRTSLVTVFAATSRFNHESERYWGTRTLALQEPSQDSIVL
LNAAEQLLDALYQPGYEYRKAGVLLAGLNPADAPGAALSLFPEAPCTRDGQHRKLMQIMDAVNRRYGHGTIHLAAEETEA
WKPLQKRLSPRYTTRWSEILEVHS
>Mature_424_residues
MFALVDCNNFYASCERVFNPALVGRPVVVLSNNDGCVIARSEEAKVLGIGMGAPEFKCRELLLRHGVAVFSSNYPLYGDM
SSRVMTTLAGFAPSIEVYSIDESFLDLSGFGRFDLERYGSEIRRTVRRHTGIPVGVGIAATKTLAKIANRIAKKHLEYDG
VCVLERDAEIQRALKLIAVGDIWGVGRQWASFLQTNGIGTAADFAAASPAWIRQHMHVTGARVQAELNGHSCLALEAVRP
VKKSICTSRSFGRTVRSKEDLRQAVATFAGRCALKLRREGLRTSLVTVFAATSRFNHESERYWGTRTLALQEPSQDSIVL
LNAAEQLLDALYQPGYEYRKAGVLLAGLNPADAPGAALSLFPEAPCTRDGQHRKLMQIMDAVNRRYGHGTIHLAAEETEA
WKPLQKRLSPRYTTRWSEILEVHS

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=426, Percent_Identity=46.7136150234742, Blast_Score=347, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 46809; Mature: 46809

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALVDCNNFYASCERVFNPALVGRPVVVLSNNDGCVIARSEEAKVLGIGMGAPEFKCRE
CEEEEECCHHHHHHHHHCCHHHCCCCEEEEECCCCEEEEECCCCEEEEECCCCCCHHHHH
LLLRHGVAVFSSNYPLYGDMSSRVMTTLAGFAPSIEVYSIDESFLDLSGFGRFDLERYGS
HHHHCCHHEEECCCCEECCHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCCCHHHHHHHH
EIRRTVRRHTGIPVGVGIAATKTLAKIANRIAKKHLEYDGVCVLERDAEIQRALKLIAVG
HHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
DIWGVGRQWASFLQTNGIGTAADFAAASPAWIRQHMHVTGARVQAELNGHSCLALEAVRP
HHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCEEEEEEECCCEEEEHHHHHH
VKKSICTSRSFGRTVRSKEDLRQAVATFAGRCALKLRREGLRTSLVTVFAATSRFNHESE
HHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RYWGTRTLALQEPSQDSIVLLNAAEQLLDALYQPGYEYRKAGVLLAGLNPADAPGAALSL
HHCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCHHHHHCCEEEECCCCCCCCCCEEEE
FPEAPCTRDGQHRKLMQIMDAVNRRYGHGTIHLAAEETEAWKPLQKRLSPRYTTRWSEIL
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHH
EVHS
HCCC
>Mature Secondary Structure
MFALVDCNNFYASCERVFNPALVGRPVVVLSNNDGCVIARSEEAKVLGIGMGAPEFKCRE
CEEEEECCHHHHHHHHHCCHHHCCCCEEEEECCCCEEEEECCCCEEEEECCCCCCHHHHH
LLLRHGVAVFSSNYPLYGDMSSRVMTTLAGFAPSIEVYSIDESFLDLSGFGRFDLERYGS
HHHHCCHHEEECCCCEECCHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCCCHHHHHHHH
EIRRTVRRHTGIPVGVGIAATKTLAKIANRIAKKHLEYDGVCVLERDAEIQRALKLIAVG
HHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
DIWGVGRQWASFLQTNGIGTAADFAAASPAWIRQHMHVTGARVQAELNGHSCLALEAVRP
HHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCEEEEEEECCCEEEEHHHHHH
VKKSICTSRSFGRTVRSKEDLRQAVATFAGRCALKLRREGLRTSLVTVFAATSRFNHESE
HHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RYWGTRTLALQEPSQDSIVLLNAAEQLLDALYQPGYEYRKAGVLLAGLNPADAPGAALSL
HHCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCHHHHHCCEEEECCCCCCCCCCEEEE
FPEAPCTRDGQHRKLMQIMDAVNRRYGHGTIHLAAEETEAWKPLQKRLSPRYTTRWSEIL
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHH
EVHS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]