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The map label for this gene is bioA [H]

Identifier: 194334974

GI number: 194334974

Start: 2357997

End: 2359283

Strand: Reverse

Name: bioA [H]

Synonym: Paes_2185

Alternate gene names: 194334974

Gene position: 2359283-2357997 (Counterclockwise)

Preceding gene: 194334975

Following gene: 194334973

Centisome position: 93.89

GC content: 55.71

Gene sequence:

>1287_bases
ATGAAGGGACACATTGATACAGATTTTGACAGGGGGCATATCTGGCACCCCTATACTTCAATGCGTGATCCGCTGCCTGT
CTATCCGGTAGCGAGGGCTTCTGGAGTGACGATCGAGCTGGAGGACGGAAGGAAGCTTGTTGACGGAATGTCGTCGTGGT
GGGCGGCTGTGCACGGTTACAACCATCCGGTGCTGAACCATGCTGTCACCCGCCAGCTTGATTCGATGAGCCATGTCATG
TTTGGAGGTCTTACCCATGAGCCCGCGGTGAAACTGGCCGGCCAGCTTATCGAGCTGACACCGGAGCCGTTGCAGAAGGT
CTTTTTCAGTGATTCCGGCTCAGTGTCTGTCGAGGTAGCCATCAAGATGGCCCTGCAGTACTGGCAGGCGGCAGGTCTGT
CCCGTAAGCGGCGTCTCCTGACGGTTCGTTCCGGATATCATGGCGATACGTTCGGGGCAATGTCGGTGTGCGATCCCGAT
ACAGGAATGCACTCCCTCTTCACTGGCATGCTCGCTGAGCAGCTTTTTGCTGAAGCTCCACAGTGCGGTTTTGATGCCGC
CTGGAATGAGAACGGTATCGAAGACCTTCACCAAAAGCTGCGGCAGCATCATGAGGCTGTTGCCGCGGTGATTATCGAGC
CTGTTGTTCAGGGTGCCGGAGGGATGCGATTTTATTCGCCTCACTATCTTATCCGTCTCAGAGAGCTGTGCGATGAGTAT
GGCGTGCTGCTGATTTTCGATGAAATTGCTACCGGGTTCGGGCGTACCGGGAAGATGTTCGCTCTTGAGCATGCGGGGGT
CGTTCCCGATATCATGTGTGTCGGCAAGGCGCTGACGGGCGGTTATATGACGTTAGCGGCAACCCTTGCAGCTGATCACG
TAGCGGATACGATCTCTTCAGCTGAACCTGGGTTGTTTATGCACGGCCCGACGTTTATGGCCAATCCGCTTGCCTGCAGT
GTCGCATCGGCAAGCATCGATCTGCTCTGCAGCCGGGACTGGGAGCAGGAGGTGCAGGATATTCAGGGCGCTCTGCAGGA
TGGGCTGTCTCCATGCAGCAGGTTCAGCGGCGTTCACGATGTTCGGGTATTGGGAGCTATCGGCGTCGTTGAACTCTGTC
AACCGGTCGATATGGCAGCCGTACAGAATTTTTTCGTTGAGAGGGGAGCCTGGGTCAGGCCGTTCGGGAGACTGATTTAT
CTTATGCCGCCATTTATCATCAGCCCATCCGAGATGGTGATTCTGACTCGTGCTGTCAGGGATGCTGTTCGGTTGATTGC
TTCCTGA

Upstream 100 bases:

>100_bases
GGATTTGGGCAAATCAGGACTTGAGGCTCTTGCCGCCCTTGTTGGGTGATGTGCGCCGGGGAATCGGGTTGAACACAACT
GCTGAAAAAAGAGTGCTGAT

Downstream 100 bases:

>100_bases
CTGGCGTGGGTCGGGTTTGTTTGATTTTTATGTTTCCATAAATTAACTTCATTTGTCCGGGTGACAGCGCGTATGATCTG
TGAGTGGCCCTATCATCAGG

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKGHIDTDFDRGHIWHPYTSMRDPLPVYPVARASGVTIELEDGRKLVDGMSSWWAAVHGYNHPVLNHAVTRQLDSMSHVM
FGGLTHEPAVKLAGQLIELTPEPLQKVFFSDSGSVSVEVAIKMALQYWQAAGLSRKRRLLTVRSGYHGDTFGAMSVCDPD
TGMHSLFTGMLAEQLFAEAPQCGFDAAWNENGIEDLHQKLRQHHEAVAAVIIEPVVQGAGGMRFYSPHYLIRLRELCDEY
GVLLIFDEIATGFGRTGKMFALEHAGVVPDIMCVGKALTGGYMTLAATLAADHVADTISSAEPGLFMHGPTFMANPLACS
VASASIDLLCSRDWEQEVQDIQGALQDGLSPCSRFSGVHDVRVLGAIGVVELCQPVDMAAVQNFFVERGAWVRPFGRLIY
LMPPFIISPSEMVILTRAVRDAVRLIAS

Sequences:

>Translated_428_residues
MKGHIDTDFDRGHIWHPYTSMRDPLPVYPVARASGVTIELEDGRKLVDGMSSWWAAVHGYNHPVLNHAVTRQLDSMSHVM
FGGLTHEPAVKLAGQLIELTPEPLQKVFFSDSGSVSVEVAIKMALQYWQAAGLSRKRRLLTVRSGYHGDTFGAMSVCDPD
TGMHSLFTGMLAEQLFAEAPQCGFDAAWNENGIEDLHQKLRQHHEAVAAVIIEPVVQGAGGMRFYSPHYLIRLRELCDEY
GVLLIFDEIATGFGRTGKMFALEHAGVVPDIMCVGKALTGGYMTLAATLAADHVADTISSAEPGLFMHGPTFMANPLACS
VASASIDLLCSRDWEQEVQDIQGALQDGLSPCSRFSGVHDVRVLGAIGVVELCQPVDMAAVQNFFVERGAWVRPFGRLIY
LMPPFIISPSEMVILTRAVRDAVRLIAS
>Mature_428_residues
MKGHIDTDFDRGHIWHPYTSMRDPLPVYPVARASGVTIELEDGRKLVDGMSSWWAAVHGYNHPVLNHAVTRQLDSMSHVM
FGGLTHEPAVKLAGQLIELTPEPLQKVFFSDSGSVSVEVAIKMALQYWQAAGLSRKRRLLTVRSGYHGDTFGAMSVCDPD
TGMHSLFTGMLAEQLFAEAPQCGFDAAWNENGIEDLHQKLRQHHEAVAAVIIEPVVQGAGGMRFYSPHYLIRLRELCDEY
GVLLIFDEIATGFGRTGKMFALEHAGVVPDIMCVGKALTGGYMTLAATLAADHVADTISSAEPGLFMHGPTFMANPLACS
VASASIDLLCSRDWEQEVQDIQGALQDGLSPCSRFSGVHDVRVLGAIGVVELCQPVDMAAVQNFFVERGAWVRPFGRLIY
LMPPFIISPSEMVILTRAVRDAVRLIAS

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=396, Percent_Identity=28.7878787878788, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI284507298, Length=307, Percent_Identity=29.6416938110749, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=26.1792452830189, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=62.7684964200477, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=32.8282828282828, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789016, Length=340, Percent_Identity=30.8823529411765, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789759, Length=354, Percent_Identity=31.638418079096, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788044, Length=343, Percent_Identity=31.4868804664723, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1787560, Length=351, Percent_Identity=28.7749287749288, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786349, Length=339, Percent_Identity=28.023598820059, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=412, Percent_Identity=27.1844660194175, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=225, Percent_Identity=32, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=22.9545454545455, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=452, Percent_Identity=45.353982300885, Blast_Score=411, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=26.1390887290168, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=315, Percent_Identity=25.7142857142857, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=337, Percent_Identity=25.8160237388724, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=28.894472361809, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356575, Length=372, Percent_Identity=25.5376344086022, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574759, Length=365, Percent_Identity=27.1232876712329, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI161085790, Length=365, Percent_Identity=27.1232876712329, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281366494, Length=283, Percent_Identity=25.7950530035336, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667139, Length=283, Percent_Identity=25.7950530035336, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667143, Length=283, Percent_Identity=25.7950530035336, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46805; Mature: 46805

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGHIDTDFDRGHIWHPYTSMRDPLPVYPVARASGVTIELEDGRKLVDGMSSWWAAVHGY
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCC
NHPVLNHAVTRQLDSMSHVMFGGLTHEPAVKLAGQLIELTPEPLQKVFFSDSGSVSVEVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEHHH
IKMALQYWQAAGLSRKRRLLTVRSGYHGDTFGAMSVCDPDTGMHSLFTGMLAEQLFAEAP
HHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QCGFDAAWNENGIEDLHQKLRQHHEAVAAVIIEPVVQGAGGMRFYSPHYLIRLRELCDEY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHC
GVLLIFDEIATGFGRTGKMFALEHAGVVPDIMCVGKALTGGYMTLAATLAADHVADTISS
CEEEEEHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
AEPGLFMHGPTFMANPLACSVASASIDLLCSRDWEQEVQDIQGALQDGLSPCSRFSGVHD
CCCCEEEECCCHHCCCHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHCCCHHHHHCCCHH
VRVLGAIGVVELCQPVDMAAVQNFFVERGAWVRPFGRLIYLMPPFIISPSEMVILTRAVR
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHEECCCCEECCCHHHHHHHHHH
DAVRLIAS
HHHHHHCC
>Mature Secondary Structure
MKGHIDTDFDRGHIWHPYTSMRDPLPVYPVARASGVTIELEDGRKLVDGMSSWWAAVHGY
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCC
NHPVLNHAVTRQLDSMSHVMFGGLTHEPAVKLAGQLIELTPEPLQKVFFSDSGSVSVEVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEHHH
IKMALQYWQAAGLSRKRRLLTVRSGYHGDTFGAMSVCDPDTGMHSLFTGMLAEQLFAEAP
HHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QCGFDAAWNENGIEDLHQKLRQHHEAVAAVIIEPVVQGAGGMRFYSPHYLIRLRELCDEY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHC
GVLLIFDEIATGFGRTGKMFALEHAGVVPDIMCVGKALTGGYMTLAATLAADHVADTISS
CEEEEEHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
AEPGLFMHGPTFMANPLACSVASASIDLLCSRDWEQEVQDIQGALQDGLSPCSRFSGVHD
CCCCEEEECCCHHCCCHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHCCCHHHHHCCCHH
VRVLGAIGVVELCQPVDMAAVQNFFVERGAWVRPFGRLIYLMPPFIISPSEMVILTRAVR
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHEECCCCEECCCHHHHHHHHHH
DAVRLIAS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595 [H]