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The map label for this gene is lysC [C]

Identifier: 194334966

GI number: 194334966

Start: 2350240

End: 2351655

Strand: Reverse

Name: lysC [C]

Synonym: Paes_2177

Alternate gene names: 194334966

Gene position: 2351655-2350240 (Counterclockwise)

Preceding gene: 194334970

Following gene: 194334965

Centisome position: 93.58

GC content: 52.4

Gene sequence:

>1416_bases
ATGGCTGTAATGAAATTCGGGGGGACGTCTGTCGGGACAGCTTCGGCTATGCGGCGGGCAATGGCGATCGTTGCTGATGT
AAAGAAGAAGAAGAGCGCTCCGCTTGTTGTACTGAGCGCCTGCAGCGGAATGACCAATCTTCTCATCGAGATTGCCGGAG
CGGCGGGAGAGGGTCGTCTTGGCGACGCTCTTGCTATGGCTGAAGAGGTCAGGCTGCATCATCTCTCCATTGCCGGGGAA
CTTGTTAAAGATCCGGTTCGAAGCGCGGCACTTCAGGAAAAAATCGAAGGGTATGTCAATGAGCTTGAAATGCTTGTCAA
GGGAGTCGATATTGTCGGTGAACTGACGGCCCGATCGTTTGATACCTTCTGCTCATTCGGAGAGCTGTTGTCGACGACCG
TTTTTTCAGAGGCGATGCTCGATGCCGGTCATGCTTGTTCCTGGGTGGATGCCCGGAGCGTGATGATCACCGACGACAAT
TTCGGTACCGCACGCCCTCTGGAGGGCCGCTGTGAAGAGAACGTGCACTCAGTGATCAAGCCGCTGCTCGATGCAGGAAC
TATCGTTGTTACCCAGGGTTTTATCGGAGCTTCGGCTGACGGAAAAACGACGACTATGGGCAGAGGTGGATCGGACTTTA
CAGCTGCGCTTCTCGGGGCATGGCTTCCCTCTGACCAGATTCAGATATGGACCGATGTGGATGGTGTGATGACCTGTGAT
CCGAGAATTGTTCCTCAGGCACGAAGTATACGGGTGCTGACCTTTTCAGAGGCGGCCGAACTTGCTTATCTTGGTGCTAA
GGTTCTCCATCCGGATACGATCGCTCCTGCGGTGAAGCAGAATATTCCGGTCTATGTGCTTAATTCCCTGCATCCGGATG
CGAAAGGTACGGTTATTACCAATGACCCTGATATTCTGGACGGTATGAGCTATGGCGGACTTGTCAAGTCGATTGCGGTC
AAGAAGGGACAGTGCATTGTCAACTTCCGTTCTAACAGGATGCTTGGCCGTCACGGTTTCCTGATAGAGTTTTTTAATGT
TTTTGCCCGTGCCGGAGTTTCTGTTGAAATGATTTCAACCAGCGAAGTGTCGGTTTCTCTGACCGTGAGCGATACTGCGG
CTGTTGACGGACTGGTCCGTGAACTGGCGGGTATGGGGGAGGTTGAACTGGAGCACAATGTCGCCACAGTGAGCGTTGTT
GGTGATAATCTCAGAATGTCGAGAGGTGTTGCCGGACGTATTTTCAGCGCGCTCAAGGATGTCAACATCCGGATGATCTC
CCAGGGGGCATCGGAAATCAATGTCGGCTTTGTTGTCGAAGAGCGGGAGGTTCCGAAAGCTGTTGAAAATCTGCATCATG
AGTTTTTCTCTCATGACGATACAAGAGGTATTTTTGAGACGCCGGCAGGAAAGTGA

Upstream 100 bases:

>100_bases
GATTCAGCCTGCATCATGTTGTTTTCCCTCAATACTATGGTTATACATTGCATAACGGAAAATCCATTCTAACGTTTAAA
AGATAACAACTGTCGGGTAT

Downstream 100 bases:

>100_bases
ATGATTGAGAACTATAACGTGTTATAAATTATGGATTACAAATCGGCAGGAGTTGATATCAGTGCGGGAGAAGAGTTTGT
CCGTCTCATCAAACCGCAGG

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MAVMKFGGTSVGTASAMRRAMAIVADVKKKKSAPLVVLSACSGMTNLLIEIAGAAGEGRLGDALAMAEEVRLHHLSIAGE
LVKDPVRSAALQEKIEGYVNELEMLVKGVDIVGELTARSFDTFCSFGELLSTTVFSEAMLDAGHACSWVDARSVMITDDN
FGTARPLEGRCEENVHSVIKPLLDAGTIVVTQGFIGASADGKTTTMGRGGSDFTAALLGAWLPSDQIQIWTDVDGVMTCD
PRIVPQARSIRVLTFSEAAELAYLGAKVLHPDTIAPAVKQNIPVYVLNSLHPDAKGTVITNDPDILDGMSYGGLVKSIAV
KKGQCIVNFRSNRMLGRHGFLIEFFNVFARAGVSVEMISTSEVSVSLTVSDTAAVDGLVRELAGMGEVELEHNVATVSVV
GDNLRMSRGVAGRIFSALKDVNIRMISQGASEINVGFVVEEREVPKAVENLHHEFFSHDDTRGIFETPAGK

Sequences:

>Translated_471_residues
MAVMKFGGTSVGTASAMRRAMAIVADVKKKKSAPLVVLSACSGMTNLLIEIAGAAGEGRLGDALAMAEEVRLHHLSIAGE
LVKDPVRSAALQEKIEGYVNELEMLVKGVDIVGELTARSFDTFCSFGELLSTTVFSEAMLDAGHACSWVDARSVMITDDN
FGTARPLEGRCEENVHSVIKPLLDAGTIVVTQGFIGASADGKTTTMGRGGSDFTAALLGAWLPSDQIQIWTDVDGVMTCD
PRIVPQARSIRVLTFSEAAELAYLGAKVLHPDTIAPAVKQNIPVYVLNSLHPDAKGTVITNDPDILDGMSYGGLVKSIAV
KKGQCIVNFRSNRMLGRHGFLIEFFNVFARAGVSVEMISTSEVSVSLTVSDTAAVDGLVRELAGMGEVELEHNVATVSVV
GDNLRMSRGVAGRIFSALKDVNIRMISQGASEINVGFVVEEREVPKAVENLHHEFFSHDDTRGIFETPAGK
>Mature_470_residues
AVMKFGGTSVGTASAMRRAMAIVADVKKKKSAPLVVLSACSGMTNLLIEIAGAAGEGRLGDALAMAEEVRLHHLSIAGEL
VKDPVRSAALQEKIEGYVNELEMLVKGVDIVGELTARSFDTFCSFGELLSTTVFSEAMLDAGHACSWVDARSVMITDDNF
GTARPLEGRCEENVHSVIKPLLDAGTIVVTQGFIGASADGKTTTMGRGGSDFTAALLGAWLPSDQIQIWTDVDGVMTCDP
RIVPQARSIRVLTFSEAAELAYLGAKVLHPDTIAPAVKQNIPVYVLNSLHPDAKGTVITNDPDILDGMSYGGLVKSIAVK
KGQCIVNFRSNRMLGRHGFLIEFFNVFARAGVSVEMISTSEVSVSLTVSDTAAVDGLVRELAGMGEVELEHNVATVSVVG
DNLRMSRGVAGRIFSALKDVNIRMISQGASEINVGFVVEEREVPKAVENLHHEFFSHDDTRGIFETPAGK

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=467, Percent_Identity=37.9014989293362, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786183, Length=481, Percent_Identity=30.5613305613306, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1790376, Length=479, Percent_Identity=24.8434237995825, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320893, Length=514, Percent_Identity=31.3229571984436, Blast_Score=208, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 50168; Mature: 50037

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMKFGGTSVGTASAMRRAMAIVADVKKKKSAPLVVLSACSGMTNLLIEIAGAAGEGRL
CEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCHHHHHHHEECCCCCCCC
GDALAMAEEVRLHHLSIAGELVKDPVRSAALQEKIEGYVNELEMLVKGVDIVGELTARSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTFCSFGELLSTTVFSEAMLDAGHACSWVDARSVMITDDNFGTARPLEGRCEENVHSVIK
HHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
PLLDAGTIVVTQGFIGASADGKTTTMGRGGSDFTAALLGAWLPSDQIQIWTDVDGVMTCD
HHHCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEECC
PRIVPQARSIRVLTFSEAAELAYLGAKVLHPDTIAPAVKQNIPVYVLNSLHPDAKGTVIT
CCCCCCCCCEEEEEECCHHHHHHHCHHHCCCCHHCHHHHCCCCEEEEECCCCCCCCCEEC
NDPDILDGMSYGGLVKSIAVKKGQCIVNFRSNRMLGRHGFLIEFFNVFARAGVSVEMIST
CCCCHHCCCCCCHHHHHHHHCCCCEEEEECCCCEECCCCHHHHHHHHHHHCCCEEEEEEC
SEVSVSLTVSDTAAVDGLVRELAGMGEVELEHNVATVSVVGDNLRMSRGVAGRIFSALKD
CCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCHHCCHHHHHHHHHHH
VNIRMISQGASEINVGFVVEEREVPKAVENLHHEFFSHDDTRGIFETPAGK
CCEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVMKFGGTSVGTASAMRRAMAIVADVKKKKSAPLVVLSACSGMTNLLIEIAGAAGEGRL
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCHHHHHHHEECCCCCCCC
GDALAMAEEVRLHHLSIAGELVKDPVRSAALQEKIEGYVNELEMLVKGVDIVGELTARSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTFCSFGELLSTTVFSEAMLDAGHACSWVDARSVMITDDNFGTARPLEGRCEENVHSVIK
HHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
PLLDAGTIVVTQGFIGASADGKTTTMGRGGSDFTAALLGAWLPSDQIQIWTDVDGVMTCD
HHHCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEECC
PRIVPQARSIRVLTFSEAAELAYLGAKVLHPDTIAPAVKQNIPVYVLNSLHPDAKGTVIT
CCCCCCCCCEEEEEECCHHHHHHHCHHHCCCCHHCHHHHCCCCEEEEECCCCCCCCCEEC
NDPDILDGMSYGGLVKSIAVKKGQCIVNFRSNRMLGRHGFLIEFFNVFARAGVSVEMIST
CCCCHHCCCCCCHHHHHHHHCCCCEEEEECCCCEECCCCHHHHHHHHHHHCCCEEEEEEC
SEVSVSLTVSDTAAVDGLVRELAGMGEVELEHNVATVSVVGDNLRMSRGVAGRIFSALKD
CCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCHHCCHHHHHHHHHHH
VNIRMISQGASEINVGFVVEEREVPKAVENLHHEFFSHDDTRGIFETPAGK
CCEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]