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The map label for this gene is purM [H]

Identifier: 194334965

GI number: 194334965

Start: 2349220

End: 2350209

Strand: Reverse

Name: purM [H]

Synonym: Paes_2176

Alternate gene names: 194334965

Gene position: 2350209-2349220 (Counterclockwise)

Preceding gene: 194334966

Following gene: 194334964

Centisome position: 93.52

GC content: 53.54

Gene sequence:

>990_bases
ATGGATTACAAATCGGCAGGAGTTGATATCAGTGCGGGAGAAGAGTTTGTCCGTCTCATCAAACCGCAGGTGCGGCAGAC
ATTCACCAGCAGGGTGATGACCGATATCGGCGCGTTCGGCGGCTTTTTTCAGCCTGATTTTTCCGGGTACAGAGAACCCG
TACTGGTCAGCAGCATTGATGGCGTCGGAACCAAGCTCAAGGTTGCCGCTGAAATTGGAAAGTATGATACTATTGGCTCC
TGTCTGGTTAACCACTGTGTCAATGATATCCTTGTATGCGGTGCACGCCCGATGTTTTTTCTCGACTACTATGCCTGCGG
AAAGCTCAAGCCTGCAATGGCCGCGGATGTGGTCAAGGGTATGGTGAGCGCCTGTAAGGGGAATTCCTGCGCGCTGATCG
GAGGCGAGACCGCTGAAATGCCGGGGGTCTATGCTGAAGATGACTTCGATCTTGCCGGGACGATTGTCGGGATGGTTGAC
CGCGAACTGGTTATAAACGGGGCCTCTATCGTCGATGGTGACGTGATGATCGGTCTGCCTTCAAGCGGCTTGCATACCAA
CGGTTACTCTCTTGCAAGAAAGGTGTTCGAGGGGCGGCTTGGTCACACGTTTGAAGGGATGGAGCGCCCGGTAGGCGAGG
AGCTGCTTCAGGTTCACCGCTCATATCTTAAGGTGGTTGATGAATGGTTGACGTCGAACGATCTCCACGGTATGTCGCAT
GTGACCGGCGGAGGACTTGTCGGCAACACGATGCGCATTATTCCTTCGGGCCTGAAGCTTGATATTGACTGGACTGCCTG
GCCGGAACCACTGATCTTCGATGTGATCCGCAAAGAGGGAGGTGTTCCTGAAGAGGATATGCGCAGAACCTTCAACCTGG
GGATCGGTCTGGTCCTTATCGTTGCAGCAGAAGCTGTCGACGATATCATGGCCGGTTTGAAAACCAGGCAGGAAAATGCG
TACATTATTGGACGTATCGCCGCCGAATAG

Upstream 100 bases:

>100_bases
AAATCTGCATCATGAGTTTTTCTCTCATGACGATACAAGAGGTATTTTTGAGACGCCGGCAGGAAAGTGAATGATTGAGA
ACTATAACGTGTTATAAATT

Downstream 100 bases:

>100_bases
GCGTACTTTTTTGAATTAATCTGATGTGCAATGCTGACACTGATTGTTATTCTGGCAGTGAGTTATCTCATTGGTTCTAT
TCCGACCAGCATTATTGCTG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MDYKSAGVDISAGEEFVRLIKPQVRQTFTSRVMTDIGAFGGFFQPDFSGYREPVLVSSIDGVGTKLKVAAEIGKYDTIGS
CLVNHCVNDILVCGARPMFFLDYYACGKLKPAMAADVVKGMVSACKGNSCALIGGETAEMPGVYAEDDFDLAGTIVGMVD
RELVINGASIVDGDVMIGLPSSGLHTNGYSLARKVFEGRLGHTFEGMERPVGEELLQVHRSYLKVVDEWLTSNDLHGMSH
VTGGGLVGNTMRIIPSGLKLDIDWTAWPEPLIFDVIRKEGGVPEEDMRRTFNLGIGLVLIVAAEAVDDIMAGLKTRQENA
YIIGRIAAE

Sequences:

>Translated_329_residues
MDYKSAGVDISAGEEFVRLIKPQVRQTFTSRVMTDIGAFGGFFQPDFSGYREPVLVSSIDGVGTKLKVAAEIGKYDTIGS
CLVNHCVNDILVCGARPMFFLDYYACGKLKPAMAADVVKGMVSACKGNSCALIGGETAEMPGVYAEDDFDLAGTIVGMVD
RELVINGASIVDGDVMIGLPSSGLHTNGYSLARKVFEGRLGHTFEGMERPVGEELLQVHRSYLKVVDEWLTSNDLHGMSH
VTGGGLVGNTMRIIPSGLKLDIDWTAWPEPLIFDVIRKEGGVPEEDMRRTFNLGIGLVLIVAAEAVDDIMAGLKTRQENA
YIIGRIAAE
>Mature_329_residues
MDYKSAGVDISAGEEFVRLIKPQVRQTFTSRVMTDIGAFGGFFQPDFSGYREPVLVSSIDGVGTKLKVAAEIGKYDTIGS
CLVNHCVNDILVCGARPMFFLDYYACGKLKPAMAADVVKGMVSACKGNSCALIGGETAEMPGVYAEDDFDLAGTIVGMVD
RELVINGASIVDGDVMIGLPSSGLHTNGYSLARKVFEGRLGHTFEGMERPVGEELLQVHRSYLKVVDEWLTSNDLHGMSH
VTGGGLVGNTMRIIPSGLKLDIDWTAWPEPLIFDVIRKEGGVPEEDMRRTFNLGIGLVLIVAAEAVDDIMAGLKTRQENA
YIIGRIAAE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=42.2155688622754, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=42.2155688622754, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=42.2155688622754, Blast_Score=271, Evalue=4e-73,
Organism=Escherichia coli, GI1788845, Length=330, Percent_Identity=45.1515151515152, Blast_Score=278, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17567511, Length=341, Percent_Identity=39.0029325513196, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=39.3491124260355, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=34.1463414634146, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35477; Mature: 35477

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKSAGVDISAGEEFVRLIKPQVRQTFTSRVMTDIGAFGGFFQPDFSGYREPVLVSSID
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC
GVGTKLKVAAEIGKYDTIGSCLVNHCVNDILVCGARPMFFLDYYACGKLKPAMAADVVKG
CCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
MVSACKGNSCALIGGETAEMPGVYAEDDFDLAGTIVGMVDRELVINGASIVDGDVMIGLP
HHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCEEECCCEEEECC
SSGLHTNGYSLARKVFEGRLGHTFEGMERPVGEELLQVHRSYLKVVDEWLTSNDLHGMSH
CCCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
VTGGGLVGNTMRIIPSGLKLDIDWTAWPEPLIFDVIRKEGGVPEEDMRRTFNLGIGLVLI
CCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
VAAEAVDDIMAGLKTRQENAYIIGRIAAE
HHHHHHHHHHHHHHCCCCCCEEEEEEECC
>Mature Secondary Structure
MDYKSAGVDISAGEEFVRLIKPQVRQTFTSRVMTDIGAFGGFFQPDFSGYREPVLVSSID
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC
GVGTKLKVAAEIGKYDTIGSCLVNHCVNDILVCGARPMFFLDYYACGKLKPAMAADVVKG
CCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
MVSACKGNSCALIGGETAEMPGVYAEDDFDLAGTIVGMVDRELVINGASIVDGDVMIGLP
HHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCEEECCCEEEECC
SSGLHTNGYSLARKVFEGRLGHTFEGMERPVGEELLQVHRSYLKVVDEWLTSNDLHGMSH
CCCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
VTGGGLVGNTMRIIPSGLKLDIDWTAWPEPLIFDVIRKEGGVPEEDMRRTFNLGIGLVLI
CCCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
VAAEAVDDIMAGLKTRQENAYIIGRIAAE
HHHHHHHHHHHHHHCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA