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The map label for this gene is gpsA

Identifier: 194334963

GI number: 194334963

Start: 2347465

End: 2348463

Strand: Reverse

Name: gpsA

Synonym: Paes_2174

Alternate gene names: 194334963

Gene position: 2348463-2347465 (Counterclockwise)

Preceding gene: 194334964

Following gene: 194334958

Centisome position: 93.46

GC content: 53.85

Gene sequence:

>999_bases
ATGATCATTACTGTTCTGGGGGCCGGAAGCTGGGGTACGACACTTGCCGTTTTGCTGGCGAACAAAGGATATGCGGTGAG
CCTCTGGGCTCACCGTCCTGATTTTGCACAGGAGCTTGCCCGTACCAGGGAAAATGTCAAATATCTGCCTGGAGTTACCT
TCCCCGACGGGCTCGAAATAGCTCAGGATATCAATGCCGCAGCGACAGATGCTGATGTTATCGTTGCCGCGGTACCTTCT
CAGGCCGTTCGTGAAACTATGGAGCTGCTCGCCGGCATCAATCTTGACGGAAAGCTCATGGTCAATGTTGCCAAGGGCAT
AGAGCTTGGCAGCGGGAAACGGCTTTCAGAGGTCATTCTTGAAACGCTTTCCGGAGTTGATCCGTCCATGGTTTCCGTGC
TCTATGGCCCAAGCCATGCCGAAGAGGTTTCAGGACTGCAGCCGACAACAGTCGTTGCGGCCTCTTCAAATCTCGATACC
GCCAAGCGGGTTCAGGAGATTTTTCATACCCGTATGTTCAGGGTCTATGTGAACACTGACATCGTTGGTGTCGAAATCGC
CGGATCGGTGAAAAACATTATCGCTATTGCAGCGGGGATTGCCGATGGTATCGGCTTCGGCGATAACGCCAAGGCGGCCA
TCATTACCCGGGGATTAGCCGAGATCTCCCGTCTGAGCGCTGCTATGGGGGGAGACCCGATGACGGTCAGCGGACTTTCC
GGTATCGGTGATCTTGTGGTGACCTGCCTGAGTAAGCATAGCAGAAACCGCTATGTCGGGGAGCAGATAGGAAAGGGAAG
AAGCCTTGATGATGTGATCAGTCATATGAACATGGTTGCCGAGGGCGTGCTGACAACGAAAGCCGTGGTTGAACTCAGCA
ACCGGCTCGGTGTCGATATGCCTATTACCAGGACCGTCTATGCGATGCTTTTTGAGCATAAGCCGGTGGAGGATGCCATT
CTTGATCTCATGACCCGCGACCCTAAACCCGAGCTGTAG

Upstream 100 bases:

>100_bases
CATTATTTATACACACCGCGCCAATATCGGCCGGCTGCTTTCCGGAAATGAAAACAGGGTGACATTCGGCAGACACGCAT
AGTGTTGCTGAAGCGCAATC

Downstream 100 bases:

>100_bases
GAGAGGCCACCGTGCCGGGCTGTTTCCTTTGCCGCTTTGTTATCGATTGTTTTTGCAAAGCGATATCCGGTCATCCGCAC
CAATGGGGCAACCACAACAA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MIITVLGAGSWGTTLAVLLANKGYAVSLWAHRPDFAQELARTRENVKYLPGVTFPDGLEIAQDINAAATDADVIVAAVPS
QAVRETMELLAGINLDGKLMVNVAKGIELGSGKRLSEVILETLSGVDPSMVSVLYGPSHAEEVSGLQPTTVVAASSNLDT
AKRVQEIFHTRMFRVYVNTDIVGVEIAGSVKNIIAIAAGIADGIGFGDNAKAAIITRGLAEISRLSAAMGGDPMTVSGLS
GIGDLVVTCLSKHSRNRYVGEQIGKGRSLDDVISHMNMVAEGVLTTKAVVELSNRLGVDMPITRTVYAMLFEHKPVEDAI
LDLMTRDPKPEL

Sequences:

>Translated_332_residues
MIITVLGAGSWGTTLAVLLANKGYAVSLWAHRPDFAQELARTRENVKYLPGVTFPDGLEIAQDINAAATDADVIVAAVPS
QAVRETMELLAGINLDGKLMVNVAKGIELGSGKRLSEVILETLSGVDPSMVSVLYGPSHAEEVSGLQPTTVVAASSNLDT
AKRVQEIFHTRMFRVYVNTDIVGVEIAGSVKNIIAIAAGIADGIGFGDNAKAAIITRGLAEISRLSAAMGGDPMTVSGLS
GIGDLVVTCLSKHSRNRYVGEQIGKGRSLDDVISHMNMVAEGVLTTKAVVELSNRLGVDMPITRTVYAMLFEHKPVEDAI
LDLMTRDPKPEL
>Mature_332_residues
MIITVLGAGSWGTTLAVLLANKGYAVSLWAHRPDFAQELARTRENVKYLPGVTFPDGLEIAQDINAAATDADVIVAAVPS
QAVRETMELLAGINLDGKLMVNVAKGIELGSGKRLSEVILETLSGVDPSMVSVLYGPSHAEEVSGLQPTTVVAASSNLDT
AKRVQEIFHTRMFRVYVNTDIVGVEIAGSVKNIIAIAAGIADGIGFGDNAKAAIITRGLAEISRLSAAMGGDPMTVSGLS
GIGDLVVTCLSKHSRNRYVGEQIGKGRSLDDVISHMNMVAEGVLTTKAVVELSNRLGVDMPITRTVYAMLFEHKPVEDAI
LDLMTRDPKPEL

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=346, Percent_Identity=29.4797687861272, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI24307999, Length=349, Percent_Identity=28.080229226361, Blast_Score=134, Evalue=8e-32,
Organism=Escherichia coli, GI1790037, Length=330, Percent_Identity=42.1212121212121, Blast_Score=261, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI32564399, Length=352, Percent_Identity=29.8295454545455, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193210136, Length=361, Percent_Identity=29.3628808864266, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32564403, Length=361, Percent_Identity=29.3628808864266, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17507425, Length=352, Percent_Identity=28.4090909090909, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI193210134, Length=349, Percent_Identity=26.647564469914, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320181, Length=350, Percent_Identity=29.7142857142857, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324513, Length=345, Percent_Identity=28.4057971014493, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI22026922, Length=343, Percent_Identity=27.9883381924198, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136200, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136204, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136202, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45551945, Length=237, Percent_Identity=31.2236286919831, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281362270, Length=237, Percent_Identity=31.2236286919831, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648969, Length=192, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_PROA2 (B4S674)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016823.1
- ProteinModelPortal:   B4S674
- SMR:   B4S674
- GeneID:   6458628
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_2174
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35134; Mature: 35134

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 191-191 BINDING 105-105 BINDING 105-105 BINDING 140-140 BINDING 255-255 BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITVLGAGSWGTTLAVLLANKGYAVSLWAHRPDFAQELARTRENVKYLPGVTFPDGLEI
CEEEEEECCCHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHCCEECCCCCCCCCHHH
AQDINAAATDADVIVAAVPSQAVRETMELLAGINLDGKLMVNVAKGIELGSGKRLSEVIL
HHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHH
ETLSGVDPSMVSVLYGPSHAEEVSGLQPTTVVAASSNLDTAKRVQEIFHTRMFRVYVNTD
HHHCCCCHHHHHEEECCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEECCC
IVGVEIAGSVKNIIAIAAGIADGIGFGDNAKAAIITRGLAEISRLSAAMGGDPMTVSGLS
EEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCC
GIGDLVVTCLSKHSRNRYVGEQIGKGRSLDDVISHMNMVAEGVLTTKAVVELSNRLGVDM
HHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PITRTVYAMLFEHKPVEDAILDLMTRDPKPEL
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIITVLGAGSWGTTLAVLLANKGYAVSLWAHRPDFAQELARTRENVKYLPGVTFPDGLEI
CEEEEEECCCHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHCCEECCCCCCCCCHHH
AQDINAAATDADVIVAAVPSQAVRETMELLAGINLDGKLMVNVAKGIELGSGKRLSEVIL
HHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHH
ETLSGVDPSMVSVLYGPSHAEEVSGLQPTTVVAASSNLDTAKRVQEIFHTRMFRVYVNTD
HHHCCCCHHHHHEEECCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEECCC
IVGVEIAGSVKNIIAIAAGIADGIGFGDNAKAAIITRGLAEISRLSAAMGGDPMTVSGLS
EEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCC
GIGDLVVTCLSKHSRNRYVGEQIGKGRSLDDVISHMNMVAEGVLTTKAVVELSNRLGVDM
HHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PITRTVYAMLFEHKPVEDAILDLMTRDPKPEL
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA