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The map label for this gene is kdsA [H]

Identifier: 194334958

GI number: 194334958

Start: 2343136

End: 2343966

Strand: Reverse

Name: kdsA [H]

Synonym: Paes_2169

Alternate gene names: 194334958

Gene position: 2343966-2343136 (Counterclockwise)

Preceding gene: 194334963

Following gene: 194334957

Centisome position: 93.28

GC content: 54.75

Gene sequence:

>831_bases
GTGGAAAAATTGCTAAAGTTCTCTATTGGCCCGCTGTCGGTTCCTGATGACAAATCATTGTTTTTCATTGCCGGGCCATG
TCTTATCGAAAGTCGTGAGATGGCTATGGAGGTTGCTGCAGAGCTGCACGCATGCTGCTCTGCTATGGCTGTCCCCTGTA
TTTTCAAGGGGTCGTTCCGCAAAGCCAACCGCTCTTCAGGAAGTTCGTTTACCGGTATCGGTGACGTGGCTGCCCTGGAA
ATTCTCGCCGAAGTCCGTGAGCGTTTTTCCATGCCGGTGCTGACCGATGTGCATGAGCGGCAGGATATTGCCCTTGCCGC
CCGCTATGTCGATGTGCTGCAGATTCCGGCCTTTCTCTGCCGTCAAACAGATCTTCTTGTTGCCGCCGGAGAGAGCGGGC
TTGCCGTCAATATCAAAAAGGGGCAGTTTATGGCGCCTGAAGATATGGCGCTTGCTGCCGACAAGGTTGCTCAGACTGGG
AATTCGCGTATCATGCTGACCGAGCGAGGGACCTCTTTCGGCTACCATAATCTGGTGGTTGATTTCAGGGGTATTGCCAG
GATGGCCAGAGCGGGCTATCCTGTTGTCTATGACGCGACGCACAGCCTTCAGCTTCCCTCGGCGGCTAACGGGGTTTCCG
GTGGGGAACGTGAATTTATGCTGCCGATGGCCCGCGCAGCGGTGGCAGCCGGTGTTCAGGCGATATTCTGTGAGGTTCAT
CCTGATCCTGATAATGCCAGCTCGGATGCGGCAACCCAGATTGCACTCAGGGACTTTCCCGGCCTGTTTTTGCAGCTTCA
GAAGCTGCATGCCTGCCTACAATCTTTGTAA

Upstream 100 bases:

>100_bases
CAATGACTTATTGAAGAAGAATGTTTATTTAATGTTGTAAATTTAAAGCTTACAACCAGTAAGTTACAACACTCTATTGT
AACTGACCATATATGTAACC

Downstream 100 bases:

>100_bases
CCATTTAAAAGAACAGTGTTGTGTCAGGAATTAATTATTTCGGTATTCAATTGTCGGCAGGAGATCATTCCGAGCGTCTG
ACGACGGCTATTTCCCGGGT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MEKLLKFSIGPLSVPDDKSLFFIAGPCLIESREMAMEVAAELHACCSAMAVPCIFKGSFRKANRSSGSSFTGIGDVAALE
ILAEVRERFSMPVLTDVHERQDIALAARYVDVLQIPAFLCRQTDLLVAAGESGLAVNIKKGQFMAPEDMALAADKVAQTG
NSRIMLTERGTSFGYHNLVVDFRGIARMARAGYPVVYDATHSLQLPSAANGVSGGEREFMLPMARAAVAAGVQAIFCEVH
PDPDNASSDAATQIALRDFPGLFLQLQKLHACLQSL

Sequences:

>Translated_276_residues
MEKLLKFSIGPLSVPDDKSLFFIAGPCLIESREMAMEVAAELHACCSAMAVPCIFKGSFRKANRSSGSSFTGIGDVAALE
ILAEVRERFSMPVLTDVHERQDIALAARYVDVLQIPAFLCRQTDLLVAAGESGLAVNIKKGQFMAPEDMALAADKVAQTG
NSRIMLTERGTSFGYHNLVVDFRGIARMARAGYPVVYDATHSLQLPSAANGVSGGEREFMLPMARAAVAAGVQAIFCEVH
PDPDNASSDAATQIALRDFPGLFLQLQKLHACLQSL
>Mature_276_residues
MEKLLKFSIGPLSVPDDKSLFFIAGPCLIESREMAMEVAAELHACCSAMAVPCIFKGSFRKANRSSGSSFTGIGDVAALE
ILAEVRERFSMPVLTDVHERQDIALAARYVDVLQIPAFLCRQTDLLVAAGESGLAVNIKKGQFMAPEDMALAADKVAQTG
NSRIMLTERGTSFGYHNLVVDFRGIARMARAGYPVVYDATHSLQLPSAANGVSGGEREFMLPMARAAVAAGVQAIFCEVH
PDPDNASSDAATQIALRDFPGLFLQLQKLHACLQSL

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=264, Percent_Identity=37.5, Blast_Score=198, Evalue=4e-52,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29639; Mature: 29639

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLLKFSIGPLSVPDDKSLFFIAGPCLIESREMAMEVAAELHACCSAMAVPCIFKGSFR
CCCHHHCCCCCCCCCCCCCEEEEECCCEECHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
KANRSSGSSFTGIGDVAALEILAEVRERFSMPVLTDVHERQDIALAARYVDVLQIPAFLC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQTDLLVAAGESGLAVNIKKGQFMAPEDMALAADKVAQTGNSRIMLTERGTSFGYHNLVV
CCCCEEEEECCCCCEEEEECCCEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHEE
DFRGIARMARAGYPVVYDATHSLQLPSAANGVSGGEREFMLPMARAAVAAGVQAIFCEVH
EHHHHHHHHHCCCCEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEC
PDPDNASSDAATQIALRDFPGLFLQLQKLHACLQSL
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLLKFSIGPLSVPDDKSLFFIAGPCLIESREMAMEVAAELHACCSAMAVPCIFKGSFR
CCCHHHCCCCCCCCCCCCCEEEEECCCEECHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
KANRSSGSSFTGIGDVAALEILAEVRERFSMPVLTDVHERQDIALAARYVDVLQIPAFLC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQTDLLVAAGESGLAVNIKKGQFMAPEDMALAADKVAQTGNSRIMLTERGTSFGYHNLVV
CCCCEEEEECCCCCEEEEECCCEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHEE
DFRGIARMARAGYPVVYDATHSLQLPSAANGVSGGEREFMLPMARAAVAAGVQAIFCEVH
EHHHHHHHHHCCCCEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEC
PDPDNASSDAATQIALRDFPGLFLQLQKLHACLQSL
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA