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The map label for this gene is moeA [H]

Identifier: 194334915

GI number: 194334915

Start: 2301506

End: 2302732

Strand: Reverse

Name: moeA [H]

Synonym: Paes_2124

Alternate gene names: 194334915

Gene position: 2302732-2301506 (Counterclockwise)

Preceding gene: 194334916

Following gene: 194334914

Centisome position: 91.64

GC content: 56.89

Gene sequence:

>1227_bases
ATGATTACCGTTCAGGAAGCCCATGCATTGATATCGAAGGCTGTTCACGTGCTGTCAGCGGAGGAGATTTCTCTCCACGT
CGCTCAGGGGCGTGTCATTGCAGAGGATATCCGGGCGGATTTTGCACTGCCTCGTTTCGATAATGCCGCCATGGACGGTT
TTGCTGTTCAGTGGGCTGATATCCGGGATGCCCGTGAGCGCCGTCCAGTCACGTTGCGGGTTAACGGCGAGATCCCTGCC
GGAGCCCCGGCCGATATCGTTGTGGAGCCCGGCAGTTGCGTGCAGATCATGACCGGGGCGCACATGCCCGAAGGGGCCGA
TACGGTGGTCGCCTATGAGCAGACCTCCGGTTTCGGTGGGGAAACGGTCGATATTTTCAAGCCGCCTGCAGCGAATGCAA
ATGTGCGCTATGCGGGCGAAGAGGTCAAGCCGGGCGATCTGCTCATGAGGAAAGGCATGCGTCTCACGCCGGCAGAGCTG
GGCGTGCTTGCTGCATTCGGTAGGTCTCATGTTCAGGTTTTTCAGCGACCTTCGATAGGTATTGTCACCGTCGGTGATGA
GTTGCGTGAACCCGGCCAGCGGCTGGACGGGGCAGCGATTTACAACAGTAATCGCTACTCGCTGGAGTCCTGTGCTCTGT
CGGCTGGAGCAGTCGTCGCGGGAAGCTGGCATGCTCCCGATCAACCGGATGCTATAGCTGAAATACTTGGCGAAGCGCTC
GCCAAGAGTGATCTTCTCATGACGGCCGGAGGTATTTCAACGGGTGAGTATGATTATATCCAGCGTCTTCTTACCGGTCT
CGGGGTCAGACAGCAATTCTGGAAAGTTGCCCATAAGCCGGGAAAACCGCTCTTTTTCGGAGATACCCCGGAAGGGAAGC
TGGTTTTCGGACTGCCCGGTAATCCGGTTTCAGCGCTCGTCTGCTTTCTCGAATATATCATGCCGGCACTCTCGGCCATG
CAGGACGGCAGCTACCATGGCAAGATCGATGCGGTGCTTGCAGAGCCCTTTCCGGCGGATCGGAAACGCTATCGCTTTCT
TTTCGGAAGAGTGTGGCAGAAAGATGGCGGTCTCTTCTGCCTGGTGAGCGATAAAACCGAATCCCATATGCTTACCTCAC
TGGTCGGATCAAACTGTCTTATCGAAGCACCAGCTGCCGCAGAGCCTTTGCCGGCCGGTTCCGTGGTGACCTGTAACCTG
CTGCCCTGGAGCACACTTCATGAGTAA

Upstream 100 bases:

>100_bases
TCTGTCTTCCGGGCAGTCCTGGTGCGGCAAGAGATGCACTTGAGGTTCTTGTTCCGACAATTTTCCATGCATTTTCCATG
ATACAGGGGGAGGGCCACCA

Downstream 100 bases:

>100_bases
TGAACACACTATGGATATTACTGTACAATGTTTTGCATCGGCACGGGAGATTCTGGCACGCAGGTCATTTCAGATGACGG
TGGCTGAAGGTACGACCATC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MITVQEAHALISKAVHVLSAEEISLHVAQGRVIAEDIRADFALPRFDNAAMDGFAVQWADIRDARERRPVTLRVNGEIPA
GAPADIVVEPGSCVQIMTGAHMPEGADTVVAYEQTSGFGGETVDIFKPPAANANVRYAGEEVKPGDLLMRKGMRLTPAEL
GVLAAFGRSHVQVFQRPSIGIVTVGDELREPGQRLDGAAIYNSNRYSLESCALSAGAVVAGSWHAPDQPDAIAEILGEAL
AKSDLLMTAGGISTGEYDYIQRLLTGLGVRQQFWKVAHKPGKPLFFGDTPEGKLVFGLPGNPVSALVCFLEYIMPALSAM
QDGSYHGKIDAVLAEPFPADRKRYRFLFGRVWQKDGGLFCLVSDKTESHMLTSLVGSNCLIEAPAAAEPLPAGSVVTCNL
LPWSTLHE

Sequences:

>Translated_408_residues
MITVQEAHALISKAVHVLSAEEISLHVAQGRVIAEDIRADFALPRFDNAAMDGFAVQWADIRDARERRPVTLRVNGEIPA
GAPADIVVEPGSCVQIMTGAHMPEGADTVVAYEQTSGFGGETVDIFKPPAANANVRYAGEEVKPGDLLMRKGMRLTPAEL
GVLAAFGRSHVQVFQRPSIGIVTVGDELREPGQRLDGAAIYNSNRYSLESCALSAGAVVAGSWHAPDQPDAIAEILGEAL
AKSDLLMTAGGISTGEYDYIQRLLTGLGVRQQFWKVAHKPGKPLFFGDTPEGKLVFGLPGNPVSALVCFLEYIMPALSAM
QDGSYHGKIDAVLAEPFPADRKRYRFLFGRVWQKDGGLFCLVSDKTESHMLTSLVGSNCLIEAPAAAEPLPAGSVVTCNL
LPWSTLHE
>Mature_408_residues
MITVQEAHALISKAVHVLSAEEISLHVAQGRVIAEDIRADFALPRFDNAAMDGFAVQWADIRDARERRPVTLRVNGEIPA
GAPADIVVEPGSCVQIMTGAHMPEGADTVVAYEQTSGFGGETVDIFKPPAANANVRYAGEEVKPGDLLMRKGMRLTPAEL
GVLAAFGRSHVQVFQRPSIGIVTVGDELREPGQRLDGAAIYNSNRYSLESCALSAGAVVAGSWHAPDQPDAIAEILGEAL
AKSDLLMTAGGISTGEYDYIQRLLTGLGVRQQFWKVAHKPGKPLFFGDTPEGKLVFGLPGNPVSALVCFLEYIMPALSAM
QDGSYHGKIDAVLAEPFPADRKRYRFLFGRVWQKDGGLFCLVSDKTESHMLTSLVGSNCLIEAPAAAEPLPAGSVVTCNL
LPWSTLHE

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=332, Percent_Identity=32.8313253012048, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI10880983, Length=332, Percent_Identity=32.8313253012048, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1787049, Length=378, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25147659, Length=377, Percent_Identity=30.2387267904509, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=336, Percent_Identity=25.297619047619, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=29.3827160493827, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=29.3827160493827, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43745; Mature: 43745

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVQEAHALISKAVHVLSAEEISLHVAQGRVIAEDIRADFALPRFDNAAMDGFAVQWAD
CEEHHHHHHHHHHHHHHHHHHHHEEEEECCCEEHHHHHHHCCCCCCCCCCCCCEEEEEHH
IRDARERRPVTLRVNGEIPAGAPADIVVEPGSCVQIMTGAHMPEGADTVVAYEQTSGFGG
HHHHHHCCCEEEEECCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCC
ETVDIFKPPAANANVRYAGEEVKPGDLLMRKGMRLTPAELGVLAAFGRSHVQVFQRPSIG
CEEEEECCCCCCCCEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCCE
IVTVGDELREPGQRLDGAAIYNSNRYSLESCALSAGAVVAGSWHAPDQPDAIAEILGEAL
EEECCHHHHCCHHHCCCEEEECCCCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHH
AKSDLLMTAGGISTGEYDYIQRLLTGLGVRQQFWKVAHKPGKPLFFGDTPEGKLVFGLPG
HHCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCCCCEEEEECCC
NPVSALVCFLEYIMPALSAMQDGSYHGKIDAVLAEPFPADRKRYRFLFGRVWQKDGGLFC
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEECCCCEEE
LVSDKTESHMLTSLVGSNCLIEAPAAAEPLPAGSVVTCNLLPWSTLHE
EECCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEECCCCHHCCC
>Mature Secondary Structure
MITVQEAHALISKAVHVLSAEEISLHVAQGRVIAEDIRADFALPRFDNAAMDGFAVQWAD
CEEHHHHHHHHHHHHHHHHHHHHEEEEECCCEEHHHHHHHCCCCCCCCCCCCCEEEEEHH
IRDARERRPVTLRVNGEIPAGAPADIVVEPGSCVQIMTGAHMPEGADTVVAYEQTSGFGG
HHHHHHCCCEEEEECCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCC
ETVDIFKPPAANANVRYAGEEVKPGDLLMRKGMRLTPAELGVLAAFGRSHVQVFQRPSIG
CEEEEECCCCCCCCEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCCE
IVTVGDELREPGQRLDGAAIYNSNRYSLESCALSAGAVVAGSWHAPDQPDAIAEILGEAL
EEECCHHHHCCHHHCCCEEEECCCCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHH
AKSDLLMTAGGISTGEYDYIQRLLTGLGVRQQFWKVAHKPGKPLFFGDTPEGKLVFGLPG
HHCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCCCCEEEEECCC
NPVSALVCFLEYIMPALSAMQDGSYHGKIDAVLAEPFPADRKRYRFLFGRVWQKDGGLFC
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEECCCCEEE
LVSDKTESHMLTSLVGSNCLIEAPAAAEPLPAGSVVTCNLLPWSTLHE
EECCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEECCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]