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The map label for this gene is moaC [H]

Identifier: 194334916

GI number: 194334916

Start: 2302729

End: 2303673

Strand: Reverse

Name: moaC [H]

Synonym: Paes_2125

Alternate gene names: 194334916

Gene position: 2303673-2302729 (Counterclockwise)

Preceding gene: 194334917

Following gene: 194334915

Centisome position: 91.67

GC content: 54.92

Gene sequence:

>945_bases
ATGTCTGGTTTTTCACATCTTGACGATGCGGGTCATGTGAGGATGGTGGATGTATCGCATAAGCCTGGTACCATGCGAAC
GGCTAAGGCTTCAGGCCATATTGCCATGAAGCCTGAAACGATTCTGATGCTGCAGGAAGGCGATATGCCCAAGGGGAATG
TGCTGACGACCGCCAAGGTTGCCGGGATCCAGGCAGCCAAGCAAACAGCCCATCTTATTCCCCTTTGTCACCAGCTCAAC
CTTTCCTGGGTCGATATTGACTTTTCTCTTCACAGCGACCGCGTTGTTATCGACGCGACGGTTTCGACAAAAGAGGCTAC
CGGTGTTGAAATGGAGGCGCTTACGGCAGTGAGCGTTGCAGCTCTGACTATGTATGATATGTGCAAGGCGGTCGATAAAA
CCATGGAAATCGGTGCGGTGCGGCTTGTGCAGAAGATCGGGGGTAAAAGCCATCATCAGAGTACATATCGTCCGCTTACA
TCGCTACTGGTGACGTCCGATTCGATTGCCGCCGGTGCAGCTGAAGACAGGTCGGGCGCGATTTTGAAGGATGGTCTTGA
GGCCGCCGGCTGCCGCGTCAGTGCGTTTCGCGTTGTGCCTGATGAACCCTCAGAGATTGCCGCTCTTGTCGACAGTTGGG
TCAGTGAGGGTGTTGAGCTGATCATAACCTCCGGGGGGACGGGGCTCGGCCCCCGAGACGTGACCGTCGAAACTCTTTTA
CCGAGATTCAGTCGTCGTCTTGCAGGCGTCGAGCAGGCGCTGCTTCAGTGGGGACAGGGAAAAATCAGGACTGCCATGCT
CTCCCGGCTTGCGGCTGGGATGATAGGCTCTTCTCTGGTTATCTGTCTTCCGGGCAGTCCTGGTGCGGCAAGAGATGCAC
TTGAGGTTCTTGTTCCGACAATTTTCCATGCATTTTCCATGATACAGGGGGAGGGCCACCAATGA

Upstream 100 bases:

>100_bases
TGTTTTCCGTTGTCGAGGGTGTATACCGCAATGCAGCACATCAACAGATTAAAGACTCTACATCCCGCTCATCGGGATCA
ACAACTCAACACGCTTTCTC

Downstream 100 bases:

>100_bases
TTACCGTTCAGGAAGCCCATGCATTGATATCGAAGGCTGTTCACGTGCTGTCAGCGGAGGAGATTTCTCTCCACGTCGCT
CAGGGGCGTGTCATTGCAGA

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSGFSHLDDAGHVRMVDVSHKPGTMRTAKASGHIAMKPETILMLQEGDMPKGNVLTTAKVAGIQAAKQTAHLIPLCHQLN
LSWVDIDFSLHSDRVVIDATVSTKEATGVEMEALTAVSVAALTMYDMCKAVDKTMEIGAVRLVQKIGGKSHHQSTYRPLT
SLLVTSDSIAAGAAEDRSGAILKDGLEAAGCRVSAFRVVPDEPSEIAALVDSWVSEGVELIITSGGTGLGPRDVTVETLL
PRFSRRLAGVEQALLQWGQGKIRTAMLSRLAAGMIGSSLVICLPGSPGAARDALEVLVPTIFHAFSMIQGEGHQ

Sequences:

>Translated_314_residues
MSGFSHLDDAGHVRMVDVSHKPGTMRTAKASGHIAMKPETILMLQEGDMPKGNVLTTAKVAGIQAAKQTAHLIPLCHQLN
LSWVDIDFSLHSDRVVIDATVSTKEATGVEMEALTAVSVAALTMYDMCKAVDKTMEIGAVRLVQKIGGKSHHQSTYRPLT
SLLVTSDSIAAGAAEDRSGAILKDGLEAAGCRVSAFRVVPDEPSEIAALVDSWVSEGVELIITSGGTGLGPRDVTVETLL
PRFSRRLAGVEQALLQWGQGKIRTAMLSRLAAGMIGSSLVICLPGSPGAARDALEVLVPTIFHAFSMIQGEGHQ
>Mature_313_residues
SGFSHLDDAGHVRMVDVSHKPGTMRTAKASGHIAMKPETILMLQEGDMPKGNVLTTAKVAGIQAAKQTAHLIPLCHQLNL
SWVDIDFSLHSDRVVIDATVSTKEATGVEMEALTAVSVAALTMYDMCKAVDKTMEIGAVRLVQKIGGKSHHQSTYRPLTS
LLVTSDSIAAGAAEDRSGAILKDGLEAAGCRVSAFRVVPDEPSEIAALVDSWVSEGVELIITSGGTGLGPRDVTVETLLP
RFSRRLAGVEQALLQWGQGKIRTAMLSRLAAGMIGSSLVICLPGSPGAARDALEVLVPTIFHAFSMIQGEGHQ

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=152, Percent_Identity=36.8421052631579, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI66932975, Length=152, Percent_Identity=36.8421052631579, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1787001, Length=152, Percent_Identity=53.2894736842105, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1787000, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=44.2953020134228, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17564954, Length=161, Percent_Identity=32.2981366459627, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574490, Length=154, Percent_Identity=48.0519480519481, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574492, Length=141, Percent_Identity=49.645390070922, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 33169; Mature: 33038

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFSHLDDAGHVRMVDVSHKPGTMRTAKASGHIAMKPETILMLQEGDMPKGNVLTTAKV
CCCCCCCCCCCCEEEEEECCCCCCCEEECCCCEEEECCCEEEEEECCCCCCCCEEEEHHH
AGIQAAKQTAHLIPLCHQLNLSWVDIDFSLHSDRVVIDATVSTKEATGVEMEALTAVSVA
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHH
ALTMYDMCKAVDKTMEIGAVRLVQKIGGKSHHQSTYRPLTSLLVTSDSIAAGAAEDRSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCC
ILKDGLEAAGCRVSAFRVVPDEPSEIAALVDSWVSEGVELIITSGGTGLGPRDVTVETLL
HHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHH
PRFSRRLAGVEQALLQWGQGKIRTAMLSRLAAGMIGSSLVICLPGSPGAARDALEVLVPT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
IFHAFSMIQGEGHQ
HHHHHHHHCCCCCC
>Mature Secondary Structure 
SGFSHLDDAGHVRMVDVSHKPGTMRTAKASGHIAMKPETILMLQEGDMPKGNVLTTAKV
CCCCCCCCCCCEEEEEECCCCCCCEEECCCCEEEECCCEEEEEECCCCCCCCEEEEHHH
AGIQAAKQTAHLIPLCHQLNLSWVDIDFSLHSDRVVIDATVSTKEATGVEMEALTAVSVA
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHH
ALTMYDMCKAVDKTMEIGAVRLVQKIGGKSHHQSTYRPLTSLLVTSDSIAAGAAEDRSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCC
ILKDGLEAAGCRVSAFRVVPDEPSEIAALVDSWVSEGVELIITSGGTGLGPRDVTVETLL
HHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHH
PRFSRRLAGVEQALLQWGQGKIRTAMLSRLAAGMIGSSLVICLPGSPGAARDALEVLVPT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
IFHAFSMIQGEGHQ
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]