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The map label for this gene is hisG

Identifier: 194334794

GI number: 194334794

Start: 2193343

End: 2194227

Strand: Reverse

Name: hisG

Synonym: Paes_1995

Alternate gene names: 194334794

Gene position: 2194227-2193343 (Counterclockwise)

Preceding gene: 194334795

Following gene: 194334793

Centisome position: 87.32

GC content: 50.06

Gene sequence:

>885_bases
ATGAGTGCATCGAAACAGCTATTGAAACTGGGTTTACCCAAAGGAAGTTTGCAGGATTCCACACTTGATTTGTTTGCAAA
AGCAGGATTTCATTTTTCTGTCAAGAGCCGGTCCTATTTTCCCTCTATTGACGACGATGAGCTTGAGGCGATCCTTATCC
GAGCCCAGGAAATGGCCCATTATGTTGAGCTTGGCGCCTTTGACGTAGGATTGACAGGCAAAGACTGGATTATCGAGACC
GATGCCGATGTGGTCGAGGTGTCTGATCTCGTCTATTCCAAAGCCTCTATGCGCCCGGTCCGCTGGGTTCTGGCTGTTCC
CGAGAGTTCGTCGATTCAGACAGTCAAAGACCTTGAGGGTAAGCATATCGCAACCGAGGTGGTCAATATCACCAAAAAGT
ATCTTGCAGAAAATAACGTTAACGCGCATGTCGAGTTCAGCTGGGGTGCTACAGAGGTCAAGCCGCCCGAACTTGCCGAT
GCCATTGTAGAGGTCACTGAAACCGGAAGTTCGCTGCGCGCCAATAAACTTCGTATCGTCGAGGTGCTTCTGGAATCCAA
CACCAAGCTCATCGCCAACCGCAATTCCTGGAACGATCCGTGGAAACGGGAAAAAATCGAGAATATGGCGATGCTGCTTC
AGGGAGCTATTCATGCACAGGGAAAAGTCGGGTTGAAAATGAATGCCCCGAAAGACGCGCTTGACAAGATTATGGCCTTC
ATTCCCGGCCTGCGTACACCGACCGTTTCGAACCTCGCCGACGACAAGTGGGTTGCGCTCGAAGTTATCGTTGACGAGCA
GACTGTCCGTTCAGTGATTCCCGACTTGAAGCGTGCCGGTGCGGAAGGTATTTTCGAATACCATATCAATAAACTGATCG
ATTGA

Upstream 100 bases:

>100_bases
TCTTGGTACCTGGATACACGGAAGCTATCCCTACGCGATCTTTGACAATGGGGTTTTTTCCCTGCAGGAACTCTCAATTT
AAATACGAGAACATCTCAAC

Downstream 100 bases:

>100_bases
TCTCTTCATGACGCAGAAAGGCCAACCGCTTCATTTCGGGTGGCCTTTTGTGCAATGTCGTTTGCCGGACCGCCGCTCTT
CTGAGCGGCTTTGTATTGCT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSASKQLLKLGLPKGSLQDSTLDLFAKAGFHFSVKSRSYFPSIDDDELEAILIRAQEMAHYVELGAFDVGLTGKDWIIET
DADVVEVSDLVYSKASMRPVRWVLAVPESSSIQTVKDLEGKHIATEVVNITKKYLAENNVNAHVEFSWGATEVKPPELAD
AIVEVTETGSSLRANKLRIVEVLLESNTKLIANRNSWNDPWKREKIENMAMLLQGAIHAQGKVGLKMNAPKDALDKIMAF
IPGLRTPTVSNLADDKWVALEVIVDEQTVRSVIPDLKRAGAEGIFEYHINKLID

Sequences:

>Translated_294_residues
MSASKQLLKLGLPKGSLQDSTLDLFAKAGFHFSVKSRSYFPSIDDDELEAILIRAQEMAHYVELGAFDVGLTGKDWIIET
DADVVEVSDLVYSKASMRPVRWVLAVPESSSIQTVKDLEGKHIATEVVNITKKYLAENNVNAHVEFSWGATEVKPPELAD
AIVEVTETGSSLRANKLRIVEVLLESNTKLIANRNSWNDPWKREKIENMAMLLQGAIHAQGKVGLKMNAPKDALDKIMAF
IPGLRTPTVSNLADDKWVALEVIVDEQTVRSVIPDLKRAGAEGIFEYHINKLID
>Mature_293_residues
SASKQLLKLGLPKGSLQDSTLDLFAKAGFHFSVKSRSYFPSIDDDELEAILIRAQEMAHYVELGAFDVGLTGKDWIIETD
ADVVEVSDLVYSKASMRPVRWVLAVPESSSIQTVKDLEGKHIATEVVNITKKYLAENNVNAHVEFSWGATEVKPPELADA
IVEVTETGSSLRANKLRIVEVLLESNTKLIANRNSWNDPWKREKIENMAMLLQGAIHAQGKVGLKMNAPKDALDKIMAFI
PGLRTPTVSNLADDKWVALEVIVDEQTVRSVIPDLKRAGAEGIFEYHINKLID

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=27.2108843537415, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320896, Length=247, Percent_Identity=28.3400809716599, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PROA2 (B4S561)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016654.1
- ProteinModelPortal:   B4S561
- SMR:   B4S561
- GeneID:   6459863
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1995
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32580; Mature: 32448

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASKQLLKLGLPKGSLQDSTLDLFAKAGFHFSVKSRSYFPSIDDDELEAILIRAQEMAH
CCCHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
YVELGAFDVGLTGKDWIIETDADVVEVSDLVYSKASMRPVRWVLAVPESSSIQTVKDLEG
HHHHCCEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCC
KHIATEVVNITKKYLAENNVNAHVEFSWGATEVKPPELADAIVEVTETGSSLRANKLRIV
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
EVLLESNTKLIANRNSWNDPWKREKIENMAMLLQGAIHAQGKVGLKMNAPKDALDKIMAF
HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
IPGLRTPTVSNLADDKWVALEVIVDEQTVRSVIPDLKRAGAEGIFEYHINKLID
HCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SASKQLLKLGLPKGSLQDSTLDLFAKAGFHFSVKSRSYFPSIDDDELEAILIRAQEMAH
CCHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
YVELGAFDVGLTGKDWIIETDADVVEVSDLVYSKASMRPVRWVLAVPESSSIQTVKDLEG
HHHHCCEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCC
KHIATEVVNITKKYLAENNVNAHVEFSWGATEVKPPELADAIVEVTETGSSLRANKLRIV
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
EVLLESNTKLIANRNSWNDPWKREKIENMAMLLQGAIHAQGKVGLKMNAPKDALDKIMAF
HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
IPGLRTPTVSNLADDKWVALEVIVDEQTVRSVIPDLKRAGAEGIFEYHINKLID
HCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA