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The map label for this gene is gne [H]

Identifier: 194334552

GI number: 194334552

Start: 1907026

End: 1908012

Strand: Reverse

Name: gne [H]

Synonym: Paes_1748

Alternate gene names: 194334552

Gene position: 1908012-1907026 (Counterclockwise)

Preceding gene: 194334553

Following gene: 194334551

Centisome position: 75.93

GC content: 38.8

Gene sequence:

>987_bases
ATGTTGGTTTCTTTGATTGGTGGATCTGGATTTGTAGGGACTCGGTTGATTGAGGCGCTTGGAAAAGAGCATTGTTCCAA
TCTGGATAAAAATCACAGTTCTCAATATGATGATATCACTGTTATTCAGGATATTCGTCATGGTGGTATAGATAATGCTT
TGCGAGATGATACGAAAACTGTGGTATTACTTGCGGCGGAGCATAGAGATGATGTGAGTCCGACCTCATTATATTATGAT
GTCAATGTTCAGGGGACAAAGAACGTACTTGATGCTATGGACCGGAAGGGATTGAGAAGCATTGTCTTTACAAGTTCCGT
TGCTGTATATGGTTTGAATAAGGAAAATCCAGATGAAGAACATCCTGCAGATCCTTTCAATCATTATGGTAAAAGTAAGT
GGAAGGCAGAAGAAGTCCTGAGAGATTGGTATCAAAAAGACCCTGAAAAAAAGTCTCTTTCAATAATTCGACCTACAGTT
ATTTTTGGAGAAGCAAATAGAGGAAATGTATACAACTTGTTGAGGCAAATAGCTTCTGGGAAATTTCTGATGATTGGTGA
TGGTGTCAACAAGAAATCAATGGCTTATGTTGGTAATATCGTGGCCTTTATCAAGTATCTTATTGAGAATGATTCGCCGG
GATACAGGGTGTATAATTATGTTGATAAACCGGACTTCAACATGAACGAACTCGTCACTCAGGTCAGGAGTGATCTACAG
CATAATGGACGCTTGATCAGGATTCCGGAAGTTATGGGTATGCTTGGAGGATATGGATTTGATATTCTGGCAAAAGCTAC
CGGTAAAAAACTTCCGATCAGTAGTGTGAGAGTGAAGAAGTTTTGTGCTACAACACAATTTTCTGCTGAAAAACTAAATG
CAAGTGGTTTTACAAGACCTTACACTCTTGAAGAAGGTTTAGAGCGTACATTGCGCTACGAGTTTATTGAAAATCATGAT
GATAAACCTGTGTTTTTTTCAGAGTAA

Upstream 100 bases:

>100_bases
ATATGGTGGTGACTGTTGGAGTGTTGAGTGTTATGTATTGATTGTCGGGACAGAAGAGTTGTATTTGGTATTCATTTTAA
TAAATAGAACCATAGTTGAT

Downstream 100 bases:

>100_bases
GTAGTTGAATTTTTTTACAAGTACTAGTGAATACTGACTGATTATGAAGCATATCCATCCGGTTTTTGACCAGATTTTAG
GGCGTGAAGATAAAGAACGT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: UDP-GlcNAc 4-epimerase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLVSLIGGSGFVGTRLIEALGKEHCSNLDKNHSSQYDDITVIQDIRHGGIDNALRDDTKTVVLLAAEHRDDVSPTSLYYD
VNVQGTKNVLDAMDRKGLRSIVFTSSVAVYGLNKENPDEEHPADPFNHYGKSKWKAEEVLRDWYQKDPEKKSLSIIRPTV
IFGEANRGNVYNLLRQIASGKFLMIGDGVNKKSMAYVGNIVAFIKYLIENDSPGYRVYNYVDKPDFNMNELVTQVRSDLQ
HNGRLIRIPEVMGMLGGYGFDILAKATGKKLPISSVRVKKFCATTQFSAEKLNASGFTRPYTLEEGLERTLRYEFIENHD
DKPVFFSE

Sequences:

>Translated_328_residues
MLVSLIGGSGFVGTRLIEALGKEHCSNLDKNHSSQYDDITVIQDIRHGGIDNALRDDTKTVVLLAAEHRDDVSPTSLYYD
VNVQGTKNVLDAMDRKGLRSIVFTSSVAVYGLNKENPDEEHPADPFNHYGKSKWKAEEVLRDWYQKDPEKKSLSIIRPTV
IFGEANRGNVYNLLRQIASGKFLMIGDGVNKKSMAYVGNIVAFIKYLIENDSPGYRVYNYVDKPDFNMNELVTQVRSDLQ
HNGRLIRIPEVMGMLGGYGFDILAKATGKKLPISSVRVKKFCATTQFSAEKLNASGFTRPYTLEEGLERTLRYEFIENHD
DKPVFFSE
>Mature_328_residues
MLVSLIGGSGFVGTRLIEALGKEHCSNLDKNHSSQYDDITVIQDIRHGGIDNALRDDTKTVVLLAAEHRDDVSPTSLYYD
VNVQGTKNVLDAMDRKGLRSIVFTSSVAVYGLNKENPDEEHPADPFNHYGKSKWKAEEVLRDWYQKDPEKKSLSIIRPTV
IFGEANRGNVYNLLRQIASGKFLMIGDGVNKKSMAYVGNIVAFIKYLIENDSPGYRVYNYVDKPDFNMNELVTQVRSDLQ
HNGRLIRIPEVMGMLGGYGFDILAKATGKKLPISSVRVKKFCATTQFSAEKLNASGFTRPYTLEEGLERTLRYEFIENHD
DKPVFFSE

Specific function: Converts UDP-GlcNAc to UDP-GalNAc. Essential for O antigen synthesis [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321437, Length=351, Percent_Identity=28.2051282051282, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.7 [H]

Molecular weight: Translated: 36958; Mature: 36958

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSLIGGSGFVGTRLIEALGKEHCSNLDKNHSSQYDDITVIQDIRHGGIDNALRDDTKT
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCE
VVLLAAEHRDDVSPTSLYYDVNVQGTKNVLDAMDRKGLRSIVFTSSVAVYGLNKENPDEE
EEEEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
HPADPFNHYGKSKWKAEEVLRDWYQKDPEKKSLSIIRPTVIFGEANRGNVYNLLRQIASG
CCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEECCEEEEECCCCCHHHHHHHHHHCC
KFLMIGDGVNKKSMAYVGNIVAFIKYLIENDSPGYRVYNYVDKPDFNMNELVTQVRSDLQ
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
HNGRLIRIPEVMGMLGGYGFDILAKATGKKLPISSVRVKKFCATTQFSAEKLNASGFTRP
HCCCEEEHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCC
YTLEEGLERTLRYEFIENHDDKPVFFSE
CCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLVSLIGGSGFVGTRLIEALGKEHCSNLDKNHSSQYDDITVIQDIRHGGIDNALRDDTKT
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCE
VVLLAAEHRDDVSPTSLYYDVNVQGTKNVLDAMDRKGLRSIVFTSSVAVYGLNKENPDEE
EEEEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
HPADPFNHYGKSKWKAEEVLRDWYQKDPEKKSLSIIRPTVIFGEANRGNVYNLLRQIASG
CCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEECCEEEEECCCCCHHHHHHHHHHCC
KFLMIGDGVNKKSMAYVGNIVAFIKYLIENDSPGYRVYNYVDKPDFNMNELVTQVRSDLQ
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
HNGRLIRIPEVMGMLGGYGFDILAKATGKKLPISSVRVKKFCATTQFSAEKLNASGFTRP
HCCCEEEHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCC
YTLEEGLERTLRYEFIENHDDKPVFFSE
CCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11976290; 11206551; 11258796 [H]