Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 194334371

GI number: 194334371

Start: 1704669

End: 1706165

Strand: Reverse

Name: trpE [H]

Synonym: Paes_1566

Alternate gene names: 194334371

Gene position: 1706165-1704669 (Counterclockwise)

Preceding gene: 194334373

Following gene: 194334370

Centisome position: 67.9

GC content: 50.9

Gene sequence:

>1497_bases
ATGTCGATATCAAGACAGAGCGAAACCTTTACGCTTCATCCTCTTATCAGCGCTGTCCATGCTGATACCGAAACCCCTGT
TTCAGTCTATCTCAAGCTTCGTGAACCCTATTCCTGCCTTCTTGAGTCGGTTGAAGGAGAGGAGCAGCTTGCCCGTTTTT
CTATTATTGCGATCGATCCTGTCGCTGTTCTTAAAGGGACGGTCAATGGGGATGTTTCTATAGACATCCGCGATAAGCGG
TTTGAACGCCTGGCAGCGATTCCCGGTGAGTCGTCCGGTTTGCGCGATGCTGTCGACCGTTGTCTCGCTCTTTTTAAAAG
CAGCGAATTTACGCCTGACGGTCCTGGCGCATCACGGATGATTACATCCGGAGCATTCGGTTATTTTGCCTACGACACCA
TGCATCTGGTAGAACGGATTCCTTCTGCCCAACTGCCCGATCCTGCCGATCTTCCTGACGTATGCCTCCTGTTATGCGAT
AAACTGGTTGTTTTCGACAATGTCAAGCGCAAGGTGTTTATCATCGTGAATTATCTCGATGAGGCTGATCGTCCGAGGGC
TGAAAAAACCATGGCAGATATCAGGGCAAGGATGTTTAATCCCTTATCAGCCCGGGAGCTGATGCTTGTACCCGAAAAGC
CTGAGCCGATTGTCTCTAATACCGAGCGGGAAGCCTATCTGGAGAAGATCCGGGTTGCCAAGGAGTACATTATGCAGGGG
GATATTTTTCAGGTACAGGTTTCGCAGCGTCTCAAACGCCATCTCAATTCACGCCCGTTTGACGTTTACCGTATGCTGCG
AACCATCAATCCTTCTCCATATCTCTATTATTTCGATATGGAGGAGTTCATGATTGTGGGTTCATCTCCTGAACTTCTGG
TCAAGGTCGCCGATGATCACGACGGCAGAAGGATCGTCGACACCCGTCCGATCGCAGGAACCCGCCCGAGAGGTGCGACA
TGGGAAGAAGACCAGCGTATCGAGAAAGAGCTTTTACGTGACGAAAAGGAGCTTGCCGAGCACTTGATGCTGATCGACTT
GAGCCGTAACGATATCGGGCGGATAGCTAAAATCGGGACGGTTGAAACCAATGAGATGATGATCATCGAGCGCTATTCGC
ATGTGATGCATATTGTCAGCAACGTTCGGGGTGAGCTGCGTGACGAATTGACGCCGATGGACGCATTCTGGGCATGCTTT
CCTGCCGGAACCCTGACAGGTGCCCCTAAAGTCAGGGCTATGGAAATCATCTATGAACTGGAGCAGGAGAAACGCGGGCT
TTATGGTGGAGCGGTCGGATTTATCGATTTCTGCGGGCAGCTTGAGACCGCTATTGCTATTCGTACCATGGTGGTTCGTG
ACGATACAGTCTATTTCCAGGCGGCCGGTGGTGTGGTTGCCGATTCTCTTGCCGAGAATGAATTCGACGAGACCATGAAC
AAAATGAGAGCGGGGCTCAGAACGCTCGAAGCGCTCGAGCATGTTTCAAACGATTGA

Upstream 100 bases:

>100_bases
CATAGAATCCGGAAGTATTGCAGTTCCTGTCCGGTTTCATGATACTAAATTTTCGCTATACATTTGCAACTGCACAAACC
ATTTGTCTTTTTCCATATCT

Downstream 100 bases:

>100_bases
TGTGTAACGATTAATTCATTGAGAACCATGAAAAGAAAATATACCTACTTGTTTCTTGTGCTCGCCGGTGTGCTGGTTGG
CGCGCTTGCTTTTTCTCATA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSISRQSETFTLHPLISAVHADTETPVSVYLKLREPYSCLLESVEGEEQLARFSIIAIDPVAVLKGTVNGDVSIDIRDKR
FERLAAIPGESSGLRDAVDRCLALFKSSEFTPDGPGASRMITSGAFGYFAYDTMHLVERIPSAQLPDPADLPDVCLLLCD
KLVVFDNVKRKVFIIVNYLDEADRPRAEKTMADIRARMFNPLSARELMLVPEKPEPIVSNTEREAYLEKIRVAKEYIMQG
DIFQVQVSQRLKRHLNSRPFDVYRMLRTINPSPYLYYFDMEEFMIVGSSPELLVKVADDHDGRRIVDTRPIAGTRPRGAT
WEEDQRIEKELLRDEKELAEHLMLIDLSRNDIGRIAKIGTVETNEMMIIERYSHVMHIVSNVRGELRDELTPMDAFWACF
PAGTLTGAPKVRAMEIIYELEQEKRGLYGGAVGFIDFCGQLETAIAIRTMVVRDDTVYFQAAGGVVADSLAENEFDETMN
KMRAGLRTLEALEHVSND

Sequences:

>Translated_498_residues
MSISRQSETFTLHPLISAVHADTETPVSVYLKLREPYSCLLESVEGEEQLARFSIIAIDPVAVLKGTVNGDVSIDIRDKR
FERLAAIPGESSGLRDAVDRCLALFKSSEFTPDGPGASRMITSGAFGYFAYDTMHLVERIPSAQLPDPADLPDVCLLLCD
KLVVFDNVKRKVFIIVNYLDEADRPRAEKTMADIRARMFNPLSARELMLVPEKPEPIVSNTEREAYLEKIRVAKEYIMQG
DIFQVQVSQRLKRHLNSRPFDVYRMLRTINPSPYLYYFDMEEFMIVGSSPELLVKVADDHDGRRIVDTRPIAGTRPRGAT
WEEDQRIEKELLRDEKELAEHLMLIDLSRNDIGRIAKIGTVETNEMMIIERYSHVMHIVSNVRGELRDELTPMDAFWACF
PAGTLTGAPKVRAMEIIYELEQEKRGLYGGAVGFIDFCGQLETAIAIRTMVVRDDTVYFQAAGGVVADSLAENEFDETMN
KMRAGLRTLEALEHVSND
>Mature_497_residues
SISRQSETFTLHPLISAVHADTETPVSVYLKLREPYSCLLESVEGEEQLARFSIIAIDPVAVLKGTVNGDVSIDIRDKRF
ERLAAIPGESSGLRDAVDRCLALFKSSEFTPDGPGASRMITSGAFGYFAYDTMHLVERIPSAQLPDPADLPDVCLLLCDK
LVVFDNVKRKVFIIVNYLDEADRPRAEKTMADIRARMFNPLSARELMLVPEKPEPIVSNTEREAYLEKIRVAKEYIMQGD
IFQVQVSQRLKRHLNSRPFDVYRMLRTINPSPYLYYFDMEEFMIVGSSPELLVKVADDHDGRRIVDTRPIAGTRPRGATW
EEDQRIEKELLRDEKELAEHLMLIDLSRNDIGRIAKIGTVETNEMMIIERYSHVMHIVSNVRGELRDELTPMDAFWACFP
AGTLTGAPKVRAMEIIYELEQEKRGLYGGAVGFIDFCGQLETAIAIRTMVVRDDTVYFQAAGGVVADSLAENEFDETMNK
MRAGLRTLEALEHVSND

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=377, Percent_Identity=38.7267904509284, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1788114, Length=455, Percent_Identity=31.6483516483516, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786809, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082077, Length=302, Percent_Identity=24.5033112582781, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=508, Percent_Identity=38.5826771653543, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6324361, Length=368, Percent_Identity=22.554347826087, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56309; Mature: 56178

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISRQSETFTLHPLISAVHADTETPVSVYLKLREPYSCLLESVEGEEQLARFSIIAIDP
CCCCCCCCCEEHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHEEEEEECH
VAVLKGTVNGDVSIDIRDKRFERLAAIPGESSGLRDAVDRCLALFKSSEFTPDGPGASRM
HHHHEECCCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
ITSGAFGYFAYDTMHLVERIPSAQLPDPADLPDVCLLLCDKLVVFDNVKRKVFIIVNYLD
HHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECC
EADRPRAEKTMADIRARMFNPLSARELMLVPEKPEPIVSNTEREAYLEKIRVAKEYIMQG
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
DIFQVQVSQRLKRHLNSRPFDVYRMLRTINPSPYLYYFDMEEFMIVGSSPELLVKVADDH
CEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEHHHEEEECCCCCEEEEEECCC
DGRRIVDTRPIAGTRPRGATWEEDQRIEKELLRDEKELAEHLMLIDLSRNDIGRIAKIGT
CCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHEEEECCCCCCCHHHEECE
VETNEMMIIERYSHVMHIVSNVRGELRDELTPMDAFWACFPAGTLTGAPKVRAMEIIYEL
ECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
EQEKRGLYGGAVGFIDFCGQLETAIAIRTMVVRDDTVYFQAAGGVVADSLAENEFDETMN
HHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHHHHHHHHHHHH
KMRAGLRTLEALEHVSND
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SISRQSETFTLHPLISAVHADTETPVSVYLKLREPYSCLLESVEGEEQLARFSIIAIDP
CCCCCCCCEEHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHEEEEEECH
VAVLKGTVNGDVSIDIRDKRFERLAAIPGESSGLRDAVDRCLALFKSSEFTPDGPGASRM
HHHHEECCCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
ITSGAFGYFAYDTMHLVERIPSAQLPDPADLPDVCLLLCDKLVVFDNVKRKVFIIVNYLD
HHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECC
EADRPRAEKTMADIRARMFNPLSARELMLVPEKPEPIVSNTEREAYLEKIRVAKEYIMQG
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
DIFQVQVSQRLKRHLNSRPFDVYRMLRTINPSPYLYYFDMEEFMIVGSSPELLVKVADDH
CEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEHHHEEEECCCCCEEEEEECCC
DGRRIVDTRPIAGTRPRGATWEEDQRIEKELLRDEKELAEHLMLIDLSRNDIGRIAKIGT
CCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHEEEECCCCCCCHHHEECE
VETNEMMIIERYSHVMHIVSNVRGELRDELTPMDAFWACFPAGTLTGAPKVRAMEIIYEL
ECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
EQEKRGLYGGAVGFIDFCGQLETAIAIRTMVVRDDTVYFQAAGGVVADSLAENEFDETMN
HHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHHHHHHHHHHHH
KMRAGLRTLEALEHVSND
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]