Click here to switch to the map view.

The map label for this gene is guaD [H]

Identifier: 194334351

GI number: 194334351

Start: 1685927

End: 1686394

Strand: Reverse

Name: guaD [H]

Synonym: Paes_1544

Alternate gene names: 194334351

Gene position: 1686394-1685927 (Counterclockwise)

Preceding gene: 194334352

Following gene: 194334350

Centisome position: 67.11

GC content: 53.42

Gene sequence:

>468_bases
ATGATGGAGAGCCGTTTTCTCGATAGAGCGCTTGCTCTTGCCGTTGAGAACGTCGCAGCAGGCGGCGGGCCTTTTGGCGC
GCTCATTGTCAGAAACGGCGAGGTTGTCGCAACGGGGGTTAACAGGGTTACAAGGGAGAATGATCCCACGTCGCACGCCG
AAGTCAATGCGATCCGGGCTGCTTCGCAAAAACTCAAAACCTTCAAGCTGGAAGGCTGTGAGCTCTATTCCTCCTGTGAA
CCCTGCCCGATGTGCATGGGGGCGATTTACTGGGCCGGAGTGACGACAGTTTACTATGGAGCCGATAGTGACGAGGCGGC
AGTGGCAGGGTTCGATGATCGGTATATTTATGATGAGCTCCGAAAAAAGCCTCAGCAGCGCACTCTCCGTTGTATTCAGA
TCCCATCCCCTTCCAACAGTGAGCCTTTTGATGCGTGGCGTTTATGTGATAACAAAGTGATCTATTGA

Upstream 100 bases:

>100_bases
ATCGTGCTTTTTGATGTTGTCTTGATGGACGATTATTTCGTGACGTCTGCCGATCTGTGTTTTCTGTTTCAGAGCATTAT
TAACCGATACTGGAAAAGTG

Downstream 100 bases:

>100_bases
GGCTGTTGCCGGGCAGAGGAGGCTCTTTGGCGCAGCAGGGGGGCTCGTACGTAATTTGCTCTTTTTTATGTACTTTATTG
TGTTCATTTCTGTTTGCAAC

Product: CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MMESRFLDRALALAVENVAAGGGPFGALIVRNGEVVATGVNRVTRENDPTSHAEVNAIRAASQKLKTFKLEGCELYSSCE
PCPMCMGAIYWAGVTTVYYGADSDEAAVAGFDDRYIYDELRKKPQQRTLRCIQIPSPSNSEPFDAWRLCDNKVIY

Sequences:

>Translated_155_residues
MMESRFLDRALALAVENVAAGGGPFGALIVRNGEVVATGVNRVTRENDPTSHAEVNAIRAASQKLKTFKLEGCELYSSCE
PCPMCMGAIYWAGVTTVYYGADSDEAAVAGFDDRYIYDELRKKPQQRTLRCIQIPSPSNSEPFDAWRLCDNKVIY
>Mature_155_residues
MMESRFLDRALALAVENVAAGGGPFGALIVRNGEVVATGVNRVTRENDPTSHAEVNAIRAASQKLKTFKLEGCELYSSCE
PCPMCMGAIYWAGVTTVYYGADSDEAAVAGFDDRYIYDELRKKPQQRTLRCIQIPSPSNSEPFDAWRLCDNKVIY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=87, Percent_Identity=36.7816091954023, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17554608, Length=150, Percent_Identity=43.3333333333333, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555996, Length=156, Percent_Identity=43.5897435897436, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541138, Length=108, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17093; Mature: 17093

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMESRFLDRALALAVENVAAGGGPFGALIVRNGEVVATGVNRVTRENDPTSHAEVNAIRA
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCHHHHCCCCCCCHHHHHHHHH
ASQKLKTFKLEGCELYSSCEPCPMCMGAIYWAGVTTVYYGADSDEAAVAGFDDRYIYDEL
HHHHHHEEECCCCHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCEEECCCCHHHHHHH
RKKPQQRTLRCIQIPSPSNSEPFDAWRLCDNKVIY
HCCHHHHCEEEEECCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MMESRFLDRALALAVENVAAGGGPFGALIVRNGEVVATGVNRVTRENDPTSHAEVNAIRA
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCHHHHCCCCCCCHHHHHHHHH
ASQKLKTFKLEGCELYSSCEPCPMCMGAIYWAGVTTVYYGADSDEAAVAGFDDRYIYDEL
HHHHHHEEECCCCHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCEEECCCCHHHHHHH
RKKPQQRTLRCIQIPSPSNSEPFDAWRLCDNKVIY
HCCHHHHCEEEEECCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]