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The map label for this gene is typA [H]

Identifier: 194334343

GI number: 194334343

Start: 1676837

End: 1678663

Strand: Reverse

Name: typA [H]

Synonym: Paes_1536

Alternate gene names: 194334343

Gene position: 1678663-1676837 (Counterclockwise)

Preceding gene: 194334348

Following gene: 194334338

Centisome position: 66.8

GC content: 49.59

Gene sequence:

>1827_bases
ATGAGTACGAAACAGAATATTCGAAATATTGCGATCATTGCCCACGTTGATCATGGTAAGACGACACTTGTTGATGCAAT
TTTTAATCATACGGGTGTTTTCAGGGATAACCAGCAGGTTGATGCCCGTGTGCTTGATTCAAACCCCCAGGAGAGGGAGA
GAGGAATCACGATCTTTTCAAAAAATGCGGCAGCTTTTTACAAAGGGCATAAAATTAATATTGTCGATACTCCCGGCCAC
GCCGATTTTGGCGGTGAGGTAGAGCGTATCCTCAAGATGGTTGACGGCGTCCTGCTTCTTGTCGATGCGTTCGAAGGACC
GATGCCTCAGACTAAATTTGTTTTGCGCAAGGCGCTTGAACTCAATCTGAAGCCTGTTGTCGTTATCAACAAGATCGACC
GTCCGCAGGCCGATCCTGTGAAGGTTCACGACCAGGTGCTTGATCTGTTTATCGCTCTTGGTGCTGATGAAGACCAGCTT
GAATTTCCCTATATGTTCACCTCTGCCAAGATGGGTATCGCAAAAGCAAGCATGGAAGATGAAGATCATGATATGAGCCT
TCTGCTTGACATGATTATCGAAGAGATGCCTTCACCGGAAAGCAGCGATGAAGATGGCTTCCAGATGCTCGTTACCACGT
TGGACTATAGCGATTATCTTGGTAAAATTGCCATTGGACGAGTTCAGAGAGGACGCGTCAGAACAGGCGATGCGCTTGTT
GTCGTTACCGATGAGGGCGTTGTGGCAAAAGGAACGGCAGCCAAGGTGTTCACCTTTGATCAGACCAGGCGCGTCGAGGT
CAAGGAGGCTGGAGCAGGCGATATTATTGCCATTTCCGGTATTGCAGGGGCCAATGTCGGTCAGACACTGGCTGCGGCTG
ATAAACCCGATGCATTGACGTCATTCGAGATCAGCAAACCGACCCTGTCGATGCTTTTTTCGGTCAACGACTCGCCCTTT
GCCGGCCTGGAAGGCAAGGAGGTTACCAGTCGCAAGATCAGGGATCGACTGATGAAGGAAGTGATGACCAATGTCGCTCT
CGACATCGAGGAAACCGACAGTGCAGATACCTTCAGGGTGTCAGGCCGCGGTGAACTGCACCTTTCGGTCCTGATCGAGA
GTATGCGTCGCGAAGGATTCGAGCTATCCATCTCGAGACCCCAGGTTATTACCCGTACGGCAGAGGATGGAACAGTACTC
GAACCGGTCGAACATGTGACCATTGATGTTCCCGATGAGTACAACGGCGTTGTCATCGAGAAAATGGGCCGCCGTAAAGC
TGAAATGAAACATATGGAAACCCTCAAAGGCGGTATGGTCCGTCTCGAGTTCGAGATTCCTACCCGTGGTCTTATCGGCT
ACAGTCAGGAGTTTACAACCGATACCAAGGGAGAAGGTATTCTTTCTCACGTTTTTCATGACTATCAGCCTTTCAAAGGC
AAACTTCCTGCGCGTGAAACCGGTGCCCTTGTTTCAGGTGATAATGGTCAGTCTGTTGCGTATGCGCTTTCCGCACTTGA
AGACAGAGGCACCTTCTTTATCGGGCCGAACGTCAAGGTTTATGAAGGTATGGTTGTCGGAGAATCGACAAGGGAGTTCG
ATATTTCTCTGAACGTGTGCAAAACCAAAAAGCTCACCAATATGCGTTCTTCGGGTGCTGACGACTCCGTGCGTCTGACC
CCGCCGAAGGTGCTGACGCTTGAGCAGGCACTTGAATTTATCAATGATGATGAACTCGTTGAGGTAACTCCTCAGAGTAT
CAGGCTCAGGAAGAGAATTCTTGATTCAAACCTTCGTGCGAAAGCCGCCAAGAAAGCCAAAGGATGA

Upstream 100 bases:

>100_bases
CAAGCCGGTTATCCGGTCGATAAGAAGCACCATGATAATCGCGAAAAAAGTGTATATTCGGCCATTCCGTTGTGAAATAT
AACTATATCTCAGAAAAAAG

Downstream 100 bases:

>100_bases
ATCGCTGAATTGTTGATGCATTGAACACACCAAGGGCGCCGACAGGCGCCCTTGGTGTTTGGGCTCGGAGGCGGCGTTGT
TGCGCTCCAGATGCTTTATT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSTKQNIRNIAIIAHVDHGKTTLVDAIFNHTGVFRDNQQVDARVLDSNPQERERGITIFSKNAAAFYKGHKINIVDTPGH
ADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALELNLKPVVVINKIDRPQADPVKVHDQVLDLFIALGADEDQL
EFPYMFTSAKMGIAKASMEDEDHDMSLLLDMIIEEMPSPESSDEDGFQMLVTTLDYSDYLGKIAIGRVQRGRVRTGDALV
VVTDEGVVAKGTAAKVFTFDQTRRVEVKEAGAGDIIAISGIAGANVGQTLAAADKPDALTSFEISKPTLSMLFSVNDSPF
AGLEGKEVTSRKIRDRLMKEVMTNVALDIEETDSADTFRVSGRGELHLSVLIESMRREGFELSISRPQVITRTAEDGTVL
EPVEHVTIDVPDEYNGVVIEKMGRRKAEMKHMETLKGGMVRLEFEIPTRGLIGYSQEFTTDTKGEGILSHVFHDYQPFKG
KLPARETGALVSGDNGQSVAYALSALEDRGTFFIGPNVKVYEGMVVGESTREFDISLNVCKTKKLTNMRSSGADDSVRLT
PPKVLTLEQALEFINDDELVEVTPQSIRLRKRILDSNLRAKAAKKAKG

Sequences:

>Translated_608_residues
MSTKQNIRNIAIIAHVDHGKTTLVDAIFNHTGVFRDNQQVDARVLDSNPQERERGITIFSKNAAAFYKGHKINIVDTPGH
ADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALELNLKPVVVINKIDRPQADPVKVHDQVLDLFIALGADEDQL
EFPYMFTSAKMGIAKASMEDEDHDMSLLLDMIIEEMPSPESSDEDGFQMLVTTLDYSDYLGKIAIGRVQRGRVRTGDALV
VVTDEGVVAKGTAAKVFTFDQTRRVEVKEAGAGDIIAISGIAGANVGQTLAAADKPDALTSFEISKPTLSMLFSVNDSPF
AGLEGKEVTSRKIRDRLMKEVMTNVALDIEETDSADTFRVSGRGELHLSVLIESMRREGFELSISRPQVITRTAEDGTVL
EPVEHVTIDVPDEYNGVVIEKMGRRKAEMKHMETLKGGMVRLEFEIPTRGLIGYSQEFTTDTKGEGILSHVFHDYQPFKG
KLPARETGALVSGDNGQSVAYALSALEDRGTFFIGPNVKVYEGMVVGESTREFDISLNVCKTKKLTNMRSSGADDSVRLT
PPKVLTLEQALEFINDDELVEVTPQSIRLRKRILDSNLRAKAAKKAKG
>Mature_607_residues
STKQNIRNIAIIAHVDHGKTTLVDAIFNHTGVFRDNQQVDARVLDSNPQERERGITIFSKNAAAFYKGHKINIVDTPGHA
DFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALELNLKPVVVINKIDRPQADPVKVHDQVLDLFIALGADEDQLE
FPYMFTSAKMGIAKASMEDEDHDMSLLLDMIIEEMPSPESSDEDGFQMLVTTLDYSDYLGKIAIGRVQRGRVRTGDALVV
VTDEGVVAKGTAAKVFTFDQTRRVEVKEAGAGDIIAISGIAGANVGQTLAAADKPDALTSFEISKPTLSMLFSVNDSPFA
GLEGKEVTSRKIRDRLMKEVMTNVALDIEETDSADTFRVSGRGELHLSVLIESMRREGFELSISRPQVITRTAEDGTVLE
PVEHVTIDVPDEYNGVVIEKMGRRKAEMKHMETLKGGMVRLEFEIPTRGLIGYSQEFTTDTKGEGILSHVFHDYQPFKGK
LPARETGALVSGDNGQSVAYALSALEDRGTFFIGPNVKVYEGMVVGESTREFDISLNVCKTKKLTNMRSSGADDSVRLTP
PKVLTLEQALEFINDDELVEVTPQSIRLRKRILDSNLRAKAAKKAKG

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=493, Percent_Identity=30.2231237322515, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.8646616541353, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=40, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=40.8163265306122, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI25306287, Length=130, Percent_Identity=43.0769230769231, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI19923640, Length=130, Percent_Identity=43.0769230769231, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI25306283, Length=130, Percent_Identity=43.0769230769231, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI34147630, Length=237, Percent_Identity=31.2236286919831, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI217272892, Length=195, Percent_Identity=32.3076923076923, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI217272894, Length=195, Percent_Identity=32.3076923076923, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=34.8837209302326, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI53729339, Length=142, Percent_Identity=34.5070422535211, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI53729337, Length=142, Percent_Identity=34.5070422535211, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI48994988, Length=604, Percent_Identity=51.4900662251656, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1788922, Length=505, Percent_Identity=30.6930693069307, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1789738, Length=167, Percent_Identity=40.1197604790419, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790412, Length=329, Percent_Identity=27.355623100304, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789737, Length=329, Percent_Identity=27.355623100304, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790835, Length=146, Percent_Identity=31.5068493150685, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789559, Length=163, Percent_Identity=33.1288343558282, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=328, Percent_Identity=33.2317073170732, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17506493, Length=162, Percent_Identity=37.037037037037, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17556745, Length=134, Percent_Identity=41.7910447761194, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=39.2307692307692, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=39.2307692307692, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=145, Percent_Identity=39.3103448275862, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=140, Percent_Identity=36.4285714285714, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=296, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17556456, Length=283, Percent_Identity=28.2685512367491, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=237, Percent_Identity=30.379746835443, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323320, Length=490, Percent_Identity=30.2040816326531, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324707, Length=151, Percent_Identity=42.3841059602649, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320593, Length=151, Percent_Identity=42.3841059602649, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324761, Length=270, Percent_Identity=31.8518518518519, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=37.2222222222222, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=38.9261744966443, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=132, Percent_Identity=40.1515151515151, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI78706572, Length=519, Percent_Identity=27.1676300578035, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574573, Length=153, Percent_Identity=40.5228758169935, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24585711, Length=154, Percent_Identity=37.6623376623377, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585713, Length=154, Percent_Identity=37.6623376623377, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=37.6623376623377, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24582462, Length=202, Percent_Identity=36.1386138613861, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281363316, Length=271, Percent_Identity=30.9963099630996, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17864358, Length=271, Percent_Identity=30.9963099630996, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357743, Length=140, Percent_Identity=37.8571428571429, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221458488, Length=164, Percent_Identity=40.8536585365854, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921738, Length=309, Percent_Identity=26.2135922330097, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66959; Mature: 66828

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKQNIRNIAIIAHVDHGKTTLVDAIFNHTGVFRDNQQVDARVLDSNPQERERGITIFS
CCCHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHCCCEEEE
KNAAAFYKGHKINIVDTPGHADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALE
CCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
LNLKPVVVINKIDRPQADPVKVHDQVLDLFIALGADEDQLEFPYMFTSAKMGIAKASMED
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEECCCCC
EDHDMSLLLDMIIEEMPSPESSDEDGFQMLVTTLDYSDYLGKIAIGRVQRGRVRTGDALV
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHEECCCCCCCEECCCEEE
VVTDEGVVAKGTAAKVFTFDQTRRVEVKEAGAGDIIAISGIAGANVGQTLAAADKPDALT
EEECCCEEECCCCEEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCHHHCCCCCCCCE
SFEISKPTLSMLFSVNDSPFAGLEGKEVTSRKIRDRLMKEVMTNVALDIEETDSADTFRV
EEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEE
SGRGELHLSVLIESMRREGFELSISRPQVITRTAEDGTVLEPVEHVTIDVPDEYNGVVIE
CCCCCEEHHHHHHHHHCCCCEEEECCCEEEEEECCCCCEECCCCEEEEECCCCCCCEEEE
KMGRRKAEMKHMETLKGGMVRLEFEIPTRGLIGYSQEFTTDTKGEGILSHVFHDYQPFKG
HHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
KLPARETGALVSGDNGQSVAYALSALEDRGTFFIGPNVKVYEGMVVGESTREFDISLNVC
CCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCCCEEEEEEEEE
KTKKLTNMRSSGADDSVRLTPPKVLTLEQALEFINDDELVEVTPQSIRLRKRILDSNLRA
CCHHHHCCCCCCCCCCEEECCCCEEEHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCHHH
KAAKKAKG
HHHHCCCC
>Mature Secondary Structure 
STKQNIRNIAIIAHVDHGKTTLVDAIFNHTGVFRDNQQVDARVLDSNPQERERGITIFS
CCHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHCCCEEEE
KNAAAFYKGHKINIVDTPGHADFGGEVERILKMVDGVLLLVDAFEGPMPQTKFVLRKALE
CCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
LNLKPVVVINKIDRPQADPVKVHDQVLDLFIALGADEDQLEFPYMFTSAKMGIAKASMED
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEECCCCC
EDHDMSLLLDMIIEEMPSPESSDEDGFQMLVTTLDYSDYLGKIAIGRVQRGRVRTGDALV
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHEECCCCCCCEECCCEEE
VVTDEGVVAKGTAAKVFTFDQTRRVEVKEAGAGDIIAISGIAGANVGQTLAAADKPDALT
EEECCCEEECCCCEEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCHHHCCCCCCCCE
SFEISKPTLSMLFSVNDSPFAGLEGKEVTSRKIRDRLMKEVMTNVALDIEETDSADTFRV
EEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEE
SGRGELHLSVLIESMRREGFELSISRPQVITRTAEDGTVLEPVEHVTIDVPDEYNGVVIE
CCCCCEEHHHHHHHHHCCCCEEEECCCEEEEEECCCCCEECCCCEEEEECCCCCCCEEEE
KMGRRKAEMKHMETLKGGMVRLEFEIPTRGLIGYSQEFTTDTKGEGILSHVFHDYQPFKG
HHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
KLPARETGALVSGDNGQSVAYALSALEDRGTFFIGPNVKVYEGMVVGESTREFDISLNVC
CCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCCCEEEEEEEEE
KTKKLTNMRSSGADDSVRLTPPKVLTLEQALEFINDDELVEVTPQSIRLRKRILDSNLRA
CCHHHHCCCCCCCCCCEEECCCCEEEHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCHHH
KAAKKAKG
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]