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The map label for this gene is hisC

Identifier: 194334190

GI number: 194334190

Start: 1503381

End: 1504454

Strand: Reverse

Name: hisC

Synonym: Paes_1382

Alternate gene names: 194334190

Gene position: 1504454-1503381 (Counterclockwise)

Preceding gene: 194334194

Following gene: 194334189

Centisome position: 59.87

GC content: 47.95

Gene sequence:

>1074_bases
ATGGCACATGATTTTAGCGGTTTGCTGAATCCATCCTTGCTGAAGATGAGCGCTTATAGTGTCGAGGGAGGGCAGCAGGC
CGAGATAAAATTGAATCAGAATGAAAGTCCGTTTGATCTGCCCTTGTGGCTGAAGGATGAGATCATGGACGAATTCAAGC
ATGAGGCATGGAACCGCTATCCGGATATTCTTCCCTTCAGGGGAATGAAGGCGTATGCGGATTTTCTTGGGATCGCACCT
GAATCAGTGATGATGAGCAACGGCTCGAATGAAATGCTCTACACGATTTTTCTTGCCTGTCTTTCCAAGGGAAGAAAAGT
GGTTATTCCAGAGCCTTCGTTTTCGCTCTATGAAAAACTGGCGGTTCTTCTTCAGGCTGATATTGTCGATGTTCCGATGC
ACGACGATCTGACCTTTGATGTTGATGCCATCATTGCAAGAACCAATCAGGAGCGGGCAGGATTTGTTGTGCTTTCGACC
CCGAACAACCCGACAAGTCAGTCATTGAGGCTCGACGATGTCCGCCGTATTGTATCCGGCGTTGAAGCGCTTGTCCTGGT
CGATGAGGCCTATGTCGAATTTTCACGAGAAGAGTCTGCGCTGACGCTGATCGATGAGTTTCCTAACCTCATCATTCTTC
GTACCATGTCCAAGGCTCTGGCTCTTGCCGGTATGCGGATCGGTTTTGCCATTACCAACCCGCAGTTGCTTTCCGAGATT
GCCAAACCAAAAATTCCTTTTACATCGGGCAGGCTGGCAGAGATTACGCTGCAGCATGTTCTTCGTCATTACTCTCTTGT
TGACGATGCCGTAGCATATATTCTTCGAGAAAGGAACCGGCTTCTTGGTGAGTTATCGTCTGTCTCAGCAATCCATACCT
TTCCGAGTGACGCGAATTTTATCATTATCAGGGTCGACGACGCCCGTCATGTTTTCCATGCGTTGCAGGATGAGGGGATT
CTTGTTCGTAACGTTTCAGGTTACCGGCTGATGGAGAATTGTCTGCGTTTTAATATCGGGCTTGAGACAGAAAATGATCT
TTTGCTTGAAAAACTGCACCGCATGAAGGGATGA

Upstream 100 bases:

>100_bases
ACAGAAAAAATATCAGGGTGGGCGGATTATGCCGTTGAAAAAAACTATCTTACCATTTGATTTTTCTGTTCAAACCGGTT
TATAAAATTGGTAAGATTTT

Downstream 100 bases:

>100_bases
AGGGATTTTCCAAGCTTAACGGTGATGAAATGGGCCGTTTGGGCGTTGAAGAATACAACGCTGCTGAAAAGCACCCGGTG
ACGATTATTCTTCACAATAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MAHDFSGLLNPSLLKMSAYSVEGGQQAEIKLNQNESPFDLPLWLKDEIMDEFKHEAWNRYPDILPFRGMKAYADFLGIAP
ESVMMSNGSNEMLYTIFLACLSKGRKVVIPEPSFSLYEKLAVLLQADIVDVPMHDDLTFDVDAIIARTNQERAGFVVLST
PNNPTSQSLRLDDVRRIVSGVEALVLVDEAYVEFSREESALTLIDEFPNLIILRTMSKALALAGMRIGFAITNPQLLSEI
AKPKIPFTSGRLAEITLQHVLRHYSLVDDAVAYILRERNRLLGELSSVSAIHTFPSDANFIIIRVDDARHVFHALQDEGI
LVRNVSGYRLMENCLRFNIGLETENDLLLEKLHRMKG

Sequences:

>Translated_357_residues
MAHDFSGLLNPSLLKMSAYSVEGGQQAEIKLNQNESPFDLPLWLKDEIMDEFKHEAWNRYPDILPFRGMKAYADFLGIAP
ESVMMSNGSNEMLYTIFLACLSKGRKVVIPEPSFSLYEKLAVLLQADIVDVPMHDDLTFDVDAIIARTNQERAGFVVLST
PNNPTSQSLRLDDVRRIVSGVEALVLVDEAYVEFSREESALTLIDEFPNLIILRTMSKALALAGMRIGFAITNPQLLSEI
AKPKIPFTSGRLAEITLQHVLRHYSLVDDAVAYILRERNRLLGELSSVSAIHTFPSDANFIIIRVDDARHVFHALQDEGI
LVRNVSGYRLMENCLRFNIGLETENDLLLEKLHRMKG
>Mature_356_residues
AHDFSGLLNPSLLKMSAYSVEGGQQAEIKLNQNESPFDLPLWLKDEIMDEFKHEAWNRYPDILPFRGMKAYADFLGIAPE
SVMMSNGSNEMLYTIFLACLSKGRKVVIPEPSFSLYEKLAVLLQADIVDVPMHDDLTFDVDAIIARTNQERAGFVVLSTP
NNPTSQSLRLDDVRRIVSGVEALVLVDEAYVEFSREESALTLIDEFPNLIILRTMSKALALAGMRIGFAITNPQLLSEIA
KPKIPFTSGRLAEITLQHVLRHYSLVDDAVAYILRERNRLLGELSSVSAIHTFPSDANFIIIRVDDARHVFHALQDEGIL
VRNVSGYRLMENCLRFNIGLETENDLLLEKLHRMKG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=337, Percent_Identity=29.673590504451, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788722, Length=177, Percent_Identity=29.9435028248588, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786816, Length=306, Percent_Identity=23.8562091503268, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=189, Percent_Identity=24.8677248677249, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=330, Percent_Identity=26.969696969697, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_PROA2 (B4S8L6)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016050.1
- ProteinModelPortal:   B4S8L6
- SMR:   B4S8L6
- GeneID:   6460486
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1382
- HOGENOM:   HBG646350
- OMA:   REPWNRY
- ProtClustDB:   CLSK637673
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40207; Mature: 40076

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00599 AA_TRANSFER_CLASS_2; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDFSGLLNPSLLKMSAYSVEGGQQAEIKLNQNESPFDLPLWLKDEIMDEFKHEAWNRY
CCCCCCCCCCCHHHEEEEEECCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCC
PDILPFRGMKAYADFLGIAPESVMMSNGSNEMLYTIFLACLSKGRKVVIPEPSFSLYEKL
CCCCCCCCHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHH
AVLLQADIVDVPMHDDLTFDVDAIIARTNQERAGFVVLSTPNNPTSQSLRLDDVRRIVSG
HHHHHHHHEECCCCCCCCCCHHHHHEECCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHH
VEALVLVDEAYVEFSREESALTLIDEFPNLIILRTMSKALALAGMRIGFAITNPQLLSEI
HHHEEEEHHHHHHHCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHEEEEECCHHHHHHH
AKPKIPFTSGRLAEITLQHVLRHYSLVDDAVAYILRERNRLLGELSSVSAIHTFPSDANF
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCE
IIIRVDDARHVFHALQDEGILVRNVSGYRLMENCLRFNIGLETENDLLLEKLHRMKG
EEEEECCHHHHHHHHCCCCEEEEECCCHHHHHHHHHEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AHDFSGLLNPSLLKMSAYSVEGGQQAEIKLNQNESPFDLPLWLKDEIMDEFKHEAWNRY
CCCCCCCCCCHHHEEEEEECCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCC
PDILPFRGMKAYADFLGIAPESVMMSNGSNEMLYTIFLACLSKGRKVVIPEPSFSLYEKL
CCCCCCCCHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHH
AVLLQADIVDVPMHDDLTFDVDAIIARTNQERAGFVVLSTPNNPTSQSLRLDDVRRIVSG
HHHHHHHHEECCCCCCCCCCHHHHHEECCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHH
VEALVLVDEAYVEFSREESALTLIDEFPNLIILRTMSKALALAGMRIGFAITNPQLLSEI
HHHEEEEHHHHHHHCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHEEEEECCHHHHHHH
AKPKIPFTSGRLAEITLQHVLRHYSLVDDAVAYILRERNRLLGELSSVSAIHTFPSDANF
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCE
IIIRVDDARHVFHALQDEGILVRNVSGYRLMENCLRFNIGLETENDLLLEKLHRMKG
EEEEECCHHHHHHHHCCCCEEEEECCCHHHHHHHHHEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA