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The map label for this gene is cbiHC [H]

Identifier: 194334102

GI number: 194334102

Start: 1408793

End: 1410202

Strand: Reverse

Name: cbiHC [H]

Synonym: Paes_1290

Alternate gene names: 194334102

Gene position: 1410202-1408793 (Counterclockwise)

Preceding gene: 194334103

Following gene: 194334101

Centisome position: 56.12

GC content: 59.15

Gene sequence:

>1410_bases
ATGAACCAAGGTCGTATTATTGTAGCCGGAATTGGGCCCGGCGATGAATCCATGGTGACACCCCAGGTGCGTCATGCCGT
CAGTGAAGCGGATGATGTCGTGGGGTACCATCGCTATATCAACCTGATCGAGGGGTGGCTTCCTGCTCATGTCAGCAGGC
ATTCGACCGGGATGACGCATGAGCAGGCCCGTGCCGACAAGGCATTTGCTCTGGCCTCTGAAGGCCGGAACGTCGTGGTC
GTGAGTTCCGGTGATGCTGGTATTTACGGGATGGCGCCCCTGATTCTCGAACTCTGTGCCAGAAGCGGGGTTTCCGGCCC
GGAACTCGTTGTGCTGCCCGGCATCAGTGCCTTCCAGGTCGCGGCGGCACGGCTCGGTGCACCGATCAGTCATGATTTCT
GCGTTATCTCTCTTTCCGACCTCATGACGCCGTGGGACGTGATCGAACGACGGATCGAGGCTGCAGCCTCGGCTGACTTC
GTCACGGCGATCTACAACCCGGCCAGTCGTGACCGGTATTGGCAGATCCATCGTTTCAAGGAACGGTTTCTCGAACATCG
TTCAGCATCGACGCCTGTCGGCATTGTCCGCCAGGCAGGCAGGGACGACGAGTCTGTCGTCCGCACGACGCTCGGGTCCT
TCGATCCCGATACCCTCGATATGTTCAGCGTCATGATCGTCGGCAATTCGTCGACATTCATGAGCGAGAACCGGATGATC
ACTCCCCGGGGGTATTTCCGGCATCAGGAACATGACGGCACCAGGCCGGGGCAGTCGATCATGATCAACAGTTTTCGAAC
CATTGCCGGATTGCTGAAACGCGACGATCATGCCTGCGATGCGAAATGGGCGCTGATTCACACGATCCATACAACAGCCG
ATTTCGAATTCGAGGATATTTTTCAGACATCTCCGGGTGCCGTGGCTACCTTGCACCGGAAGCTGACAGCGGGGGGAGCC
GTGATCATCACCGATGTCACCATGGTGCAGTCCGGACTGCGCAAGGCGGCGCTGAAGCGGTACGGCATTCGTGTGCACTG
CTACCTGACGGACCCGCGAGTGCCGGAACTGGCCGCTGCCGAGGGCATAACCCGAACCCAGGCGGGTATAAGGCTGGCCG
CGAATGAGCATCCGGATGCCCTGTTCGTGATCGGTAACGCCCCGACGGCGCTTATGGAACTGGCAGATCTTCTCCACAGG
ACCGATCTTTCACCTATGGGTGTGATCGGTGCACCGGTCGGGTTTGTCAATGTCGTGGAGTCCAAGCTGCGCCTCAAGGC
TGCCTGCCGGATAACGCCGTACGTGGTGATCGAAGGCCGCAAGGGAGGCAGTTCGGTTGCCGCGACCATCGTGAACGCGG
CAATGAGCCTCGAGGATGCCCAGGCAATGAAACCGGGAAGAGATGTCTGA

Upstream 100 bases:

>100_bases
TGACATCCGAGAAAGAAGAGCTCCGGAACCGTATCATACCGTATTTTTCCCTGCTGATCTGTTCCCGCAACGGCAGTCAG
CGATAAACCTGATATCTGTT

Downstream 100 bases:

>100_bases
GAAGTTTCTTGTGATCGGCCTCAGTGACAGCCGTTCCCCGGTTTTCGATCCTCAAACCCTGCGAGAGATCGCCGCATGCA
GGGTGTTTGCCGGAGGTGAG

Product: precorrin-3B C17-methyltransferase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin-3B C(17)-methyltransferase; Cobalt-precorrin-3 methylase; Cobalt-precorrin-3 methyltransferase; Cobalt-precorrin-8X methylmutase; Cobalt-precorrin isomerase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNQGRIIVAGIGPGDESMVTPQVRHAVSEADDVVGYHRYINLIEGWLPAHVSRHSTGMTHEQARADKAFALASEGRNVVV
VSSGDAGIYGMAPLILELCARSGVSGPELVVLPGISAFQVAAARLGAPISHDFCVISLSDLMTPWDVIERRIEAAASADF
VTAIYNPASRDRYWQIHRFKERFLEHRSASTPVGIVRQAGRDDESVVRTTLGSFDPDTLDMFSVMIVGNSSTFMSENRMI
TPRGYFRHQEHDGTRPGQSIMINSFRTIAGLLKRDDHACDAKWALIHTIHTTADFEFEDIFQTSPGAVATLHRKLTAGGA
VIITDVTMVQSGLRKAALKRYGIRVHCYLTDPRVPELAAAEGITRTQAGIRLAANEHPDALFVIGNAPTALMELADLLHR
TDLSPMGVIGAPVGFVNVVESKLRLKAACRITPYVVIEGRKGGSSVAATIVNAAMSLEDAQAMKPGRDV

Sequences:

>Translated_469_residues
MNQGRIIVAGIGPGDESMVTPQVRHAVSEADDVVGYHRYINLIEGWLPAHVSRHSTGMTHEQARADKAFALASEGRNVVV
VSSGDAGIYGMAPLILELCARSGVSGPELVVLPGISAFQVAAARLGAPISHDFCVISLSDLMTPWDVIERRIEAAASADF
VTAIYNPASRDRYWQIHRFKERFLEHRSASTPVGIVRQAGRDDESVVRTTLGSFDPDTLDMFSVMIVGNSSTFMSENRMI
TPRGYFRHQEHDGTRPGQSIMINSFRTIAGLLKRDDHACDAKWALIHTIHTTADFEFEDIFQTSPGAVATLHRKLTAGGA
VIITDVTMVQSGLRKAALKRYGIRVHCYLTDPRVPELAAAEGITRTQAGIRLAANEHPDALFVIGNAPTALMELADLLHR
TDLSPMGVIGAPVGFVNVVESKLRLKAACRITPYVVIEGRKGGSSVAATIVNAAMSLEDAQAMKPGRDV
>Mature_469_residues
MNQGRIIVAGIGPGDESMVTPQVRHAVSEADDVVGYHRYINLIEGWLPAHVSRHSTGMTHEQARADKAFALASEGRNVVV
VSSGDAGIYGMAPLILELCARSGVSGPELVVLPGISAFQVAAARLGAPISHDFCVISLSDLMTPWDVIERRIEAAASADF
VTAIYNPASRDRYWQIHRFKERFLEHRSASTPVGIVRQAGRDDESVVRTTLGSFDPDTLDMFSVMIVGNSSTFMSENRMI
TPRGYFRHQEHDGTRPGQSIMINSFRTIAGLLKRDDHACDAKWALIHTIHTTADFEFEDIFQTSPGAVATLHRKLTAGGA
VIITDVTMVQSGLRKAALKRYGIRVHCYLTDPRVPELAAAEGITRTQAGIRLAANEHPDALFVIGNAPTALMELADLLHR
TDLSPMGVIGAPVGFVNVVESKLRLKAACRITPYVVIEGRKGGSSVAATIVNAAMSLEDAQAMKPGRDV

Specific function: Bifunctional enzyme with a methyltransferase domain that catalyzes the methylation of C-17 in cobalt-precorrin-3B to form cobalt-precorrin-4 and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration

COG id: COG1010

COG function: function code H; Precorrin-3B methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014422
- InterPro:   IPR003722
- InterPro:   IPR006363 [H]

Pfam domain/function: PF02570 CbiC; PF00590 TP_methylase [H]

EC number: 5.4.1.2; 2.1.1.131

Molecular weight: Translated: 50784; Mature: 50784

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQGRIIVAGIGPGDESMVTPQVRHAVSEADDVVGYHRYINLIEGWLPAHVSRHSTGMTH
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EQARADKAFALASEGRNVVVVSSGDAGIYGMAPLILELCARSGVSGPELVVLPGISAFQV
HHHHHHHHEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
AAARLGAPISHDFCVISLSDLMTPWDVIERRIEAAASADFVTAIYNPASRDRYWQIHRFK
HHHHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHH
ERFLEHRSASTPVGIVRQAGRDDESVVRTTLGSFDPDTLDMFSVMIVGNSSTFMSENRMI
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCHHEEEEEEEECCCCCEECCCCEE
TPRGYFRHQEHDGTRPGQSIMINSFRTIAGLLKRDDHACDAKWALIHTIHTTADFEFEDI
CCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHH
FQTSPGAVATLHRKLTAGGAVIITDVTMVQSGLRKAALKRYGIRVHCYLTDPRVPELAAA
HCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHH
EGITRTQAGIRLAANEHPDALFVIGNAPTALMELADLLHRTDLSPMGVIGAPVGFVNVVE
CCCHHHCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SKLRLKAACRITPYVVIEGRKGGSSVAATIVNAAMSLEDAQAMKPGRDV
HHHHHHHHEEECEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNQGRIIVAGIGPGDESMVTPQVRHAVSEADDVVGYHRYINLIEGWLPAHVSRHSTGMTH
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EQARADKAFALASEGRNVVVVSSGDAGIYGMAPLILELCARSGVSGPELVVLPGISAFQV
HHHHHHHHEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
AAARLGAPISHDFCVISLSDLMTPWDVIERRIEAAASADFVTAIYNPASRDRYWQIHRFK
HHHHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHH
ERFLEHRSASTPVGIVRQAGRDDESVVRTTLGSFDPDTLDMFSVMIVGNSSTFMSENRMI
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCHHEEEEEEEECCCCCEECCCCEE
TPRGYFRHQEHDGTRPGQSIMINSFRTIAGLLKRDDHACDAKWALIHTIHTTADFEFEDI
CCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHH
FQTSPGAVATLHRKLTAGGAVIITDVTMVQSGLRKAALKRYGIRVHCYLTDPRVPELAAA
HCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHH
EGITRTQAGIRLAANEHPDALFVIGNAPTALMELADLLHRTDLSPMGVIGAPVGFVNVVE
CCCHHHCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SKLRLKAACRITPYVVIEGRKGGSSVAATIVNAAMSLEDAQAMKPGRDV
HHHHHHHHEEECEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]