Click here to switch to the map view.

The map label for this gene is gltT [H]

Identifier: 194333828

GI number: 194333828

Start: 1104944

End: 1106242

Strand: Reverse

Name: gltT [H]

Synonym: Paes_1002

Alternate gene names: 194333828

Gene position: 1106242-1104944 (Counterclockwise)

Preceding gene: 194333830

Following gene: 194333823

Centisome position: 44.02

GC content: 52.66

Gene sequence:

>1299_bases
TTGCAGAACAACAAACTTCTCATTGGCATTCTTGCAGGAATTCTCTCCGGTACGCTTATCGGAGGATTTTTTCCAGCCGT
CGGCAACGAAATCTCGTTTATCGGAGACCTCTTCATACGAACACTTTCGATGCTTGTCATGCCACTCATTATCGCGGCAA
TGATAACCGGCATCAGCAGGCTCGGGGACATACGGAAGCTCGGCTCGCTGGGAAGAGTAACCATCAGCTACTACCTTGGC
ACCACCGCAGTCGCCGTTATCACAGGAATAACCCTGGTTGTTCTGCTCCAACCCGGCAACCCCGGTATTGCAACGCCACC
AACAGAACCGCCATCAGCAATAACGGCAACGCACAATGAATCCCTGATGGACGAAGCACCGCAAACCCGAAGAGCACAAG
AAGAAGAGCGCACCATCCAGGGACTGCTCAAAGAGGTGATTACCGGCCTTGTCCCATCAAATCTTTTCAAGGCTATGGCG
GAAAATGATATCCTGCCGATCATTGTCTTTTCACTCCTCCTGGGAGGCGTTCTGACAACGATGGGAGAACAAGGCCGACC
GGTTCTGGACTTTTTCGTCAGCCTCAACGAAGCAGTGATGAAAATCATTCACCTGATCATGTATACCGCACCTGTCGGAA
TAGGGGCTCTTATTGCAGGACGACTGAGCAGCGCCGGAGGATTTAACGGATTCATCCCTGAACTCATGCGCCTCGGCAGC
TATTCGCTGACTGTCATTGCCGGGCTCATGATTCACAGCATCATCGTCCTGCCTCTCCTCCTGAAATTTATCGGGAGAAC
ACCTCCCGGACGGTTCGCCGCCAACACCTCTCCTGCTCTCCTGACAGCCTTTTCAACAGCCTCAAGCTCGGCAACGCTTC
CGGTCACCATGGAATGCGCCGAAGAAAAAAACAATGTCTCAGCCCGAACAGCAGGATTCACGCTTCCCCTTGGAGCGACA
ATCAACATGGACGGCACCGCTCTTTATGAAGCAGTTGCCGTTATATTTATCGCCCAGATGAACGGAATCATACTGACGGG
GCCGGAACTCGGCATCGTCTTTCTCACAGCAACACTTGCGGCAATCGGAGCCGCGGGTATTCCTGAAGCAGGGCTGGTCA
CTATGGTTCTGGTCCTGAAAGCGGTCAACCTTCCAGTGGAAGGCATTTCGCTCATTCTTGCTATAGACTGGTTCCTCGAC
CGTTGCAGGACAATGGTCAACGTATGGGGAGACAGTGTTGGGGCGAAGGTCATTGACCGCTACCTTAACGGAAAAACAAG
CCAGCACCTGAACAGGTGA

Upstream 100 bases:

>100_bases
AGCGGCATCCTGAAAAATGAGCTTATATATACAAAAATAATGTAAAAAACCGTACTTTTGACACGATCATCATCCGCAAA
AACCCAACCACTCCCGACCC

Downstream 100 bases:

>100_bases
TCGAGCATCTACTCTTCAATCACGATAACCAGGCAGCGTGATTTTTTCCAGAACTCGTTTTCGTCCCTGATAAGCAGCAG
AGCAGAACTCTCTCCGCCTA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MQNNKLLIGILAGILSGTLIGGFFPAVGNEISFIGDLFIRTLSMLVMPLIIAAMITGISRLGDIRKLGSLGRVTISYYLG
TTAVAVITGITLVVLLQPGNPGIATPPTEPPSAITATHNESLMDEAPQTRRAQEEERTIQGLLKEVITGLVPSNLFKAMA
ENDILPIIVFSLLLGGVLTTMGEQGRPVLDFFVSLNEAVMKIIHLIMYTAPVGIGALIAGRLSSAGGFNGFIPELMRLGS
YSLTVIAGLMIHSIIVLPLLLKFIGRTPPGRFAANTSPALLTAFSTASSSATLPVTMECAEEKNNVSARTAGFTLPLGAT
INMDGTALYEAVAVIFIAQMNGIILTGPELGIVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGISLILAIDWFLD
RCRTMVNVWGDSVGAKVIDRYLNGKTSQHLNR

Sequences:

>Translated_432_residues
MQNNKLLIGILAGILSGTLIGGFFPAVGNEISFIGDLFIRTLSMLVMPLIIAAMITGISRLGDIRKLGSLGRVTISYYLG
TTAVAVITGITLVVLLQPGNPGIATPPTEPPSAITATHNESLMDEAPQTRRAQEEERTIQGLLKEVITGLVPSNLFKAMA
ENDILPIIVFSLLLGGVLTTMGEQGRPVLDFFVSLNEAVMKIIHLIMYTAPVGIGALIAGRLSSAGGFNGFIPELMRLGS
YSLTVIAGLMIHSIIVLPLLLKFIGRTPPGRFAANTSPALLTAFSTASSSATLPVTMECAEEKNNVSARTAGFTLPLGAT
INMDGTALYEAVAVIFIAQMNGIILTGPELGIVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGISLILAIDWFLD
RCRTMVNVWGDSVGAKVIDRYLNGKTSQHLNR
>Mature_432_residues
MQNNKLLIGILAGILSGTLIGGFFPAVGNEISFIGDLFIRTLSMLVMPLIIAAMITGISRLGDIRKLGSLGRVTISYYLG
TTAVAVITGITLVVLLQPGNPGIATPPTEPPSAITATHNESLMDEAPQTRRAQEEERTIQGLLKEVITGLVPSNLFKAMA
ENDILPIIVFSLLLGGVLTTMGEQGRPVLDFFVSLNEAVMKIIHLIMYTAPVGIGALIAGRLSSAGGFNGFIPELMRLGS
YSLTVIAGLMIHSIIVLPLLLKFIGRTPPGRFAANTSPALLTAFSTASSSATLPVTMECAEEKNNVSARTAGFTLPLGAT
INMDGTALYEAVAVIFIAQMNGIILTGPELGIVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGISLILAIDWFLD
RCRTMVNVWGDSVGAKVIDRYLNGKTSQHLNR

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=466, Percent_Identity=40.1287553648069, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI169790839, Length=423, Percent_Identity=42.080378250591, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI40254478, Length=471, Percent_Identity=40.9766454352442, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI4827012, Length=444, Percent_Identity=39.8648648648649, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI194239697, Length=467, Percent_Identity=37.6873661670236, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI21314632, Length=430, Percent_Identity=33.953488372093, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI5032093, Length=413, Percent_Identity=37.772397094431, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI223468566, Length=294, Percent_Identity=41.8367346938776, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI223468564, Length=266, Percent_Identity=43.609022556391, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI262359914, Length=423, Percent_Identity=35.2245862884161, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI301601644, Length=176, Percent_Identity=41.4772727272727, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1790514, Length=432, Percent_Identity=32.4074074074074, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789947, Length=434, Percent_Identity=26.4976958525346, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788024, Length=408, Percent_Identity=26.2254901960784, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789473, Length=276, Percent_Identity=28.6231884057971, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71983106, Length=460, Percent_Identity=38.9130434782609, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71983099, Length=460, Percent_Identity=38.9130434782609, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71996953, Length=432, Percent_Identity=41.2037037037037, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI193206505, Length=452, Percent_Identity=38.2743362831858, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17537407, Length=448, Percent_Identity=39.0625, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI193206654, Length=453, Percent_Identity=35.0993377483444, Blast_Score=251, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17541374, Length=424, Percent_Identity=38.6792452830189, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24583025, Length=454, Percent_Identity=34.8017621145374, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI17137668, Length=454, Percent_Identity=34.8017621145374, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24583023, Length=454, Percent_Identity=34.8017621145374, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI281360481, Length=464, Percent_Identity=33.1896551724138, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI281360483, Length=464, Percent_Identity=33.1896551724138, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17137666, Length=464, Percent_Identity=33.1896551724138, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45520; Mature: 45520

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNKLLIGILAGILSGTLIGGFFPAVGNEISFIGDLFIRTLSMLVMPLIIAAMITGISR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIRKLGSLGRVTISYYLGTTAVAVITGITLVVLLQPGNPGIATPPTEPPSAITATHNE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEECCCH
SLMDEAPQTRRAQEEERTIQGLLKEVITGLVPSNLFKAMAENDILPIIVFSLLLGGVLTT
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MGEQGRPVLDFFVSLNEAVMKIIHLIMYTAPVGIGALIAGRLSSAGGFNGFIPELMRLGS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
YSLTVIAGLMIHSIIVLPLLLKFIGRTPPGRFAANTSPALLTAFSTASSSATLPVTMECA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCEEEHHHH
EEKNNVSARTAGFTLPLGATINMDGTALYEAVAVIFIAQMNGIILTGPELGIVFLTATLA
HCCCCCCCEECCEEEECCCEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHH
AIGAAGIPEAGLVTMVLVLKAVNLPVEGISLILAIDWFLDRCRTMVNVWGDSVGAKVIDR
HHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YLNGKTSQHLNR
HHCCCCHHHCCC
>Mature Secondary Structure
MQNNKLLIGILAGILSGTLIGGFFPAVGNEISFIGDLFIRTLSMLVMPLIIAAMITGISR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIRKLGSLGRVTISYYLGTTAVAVITGITLVVLLQPGNPGIATPPTEPPSAITATHNE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEECCCH
SLMDEAPQTRRAQEEERTIQGLLKEVITGLVPSNLFKAMAENDILPIIVFSLLLGGVLTT
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MGEQGRPVLDFFVSLNEAVMKIIHLIMYTAPVGIGALIAGRLSSAGGFNGFIPELMRLGS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
YSLTVIAGLMIHSIIVLPLLLKFIGRTPPGRFAANTSPALLTAFSTASSSATLPVTMECA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCEEEHHHH
EEKNNVSARTAGFTLPLGATINMDGTALYEAVAVIFIAQMNGIILTGPELGIVFLTATLA
HCCCCCCCEECCEEEECCCEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHH
AIGAAGIPEAGLVTMVLVLKAVNLPVEGISLILAIDWFLDRCRTMVNVWGDSVGAKVIDR
HHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YLNGKTSQHLNR
HHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]