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The map label for this gene is modD [H]

Identifier: 194333738

GI number: 194333738

Start: 996069

End: 996881

Strand: Reverse

Name: modD [H]

Synonym: Paes_0908

Alternate gene names: 194333738

Gene position: 996881-996069 (Counterclockwise)

Preceding gene: 194333743

Following gene: 194333731

Centisome position: 39.67

GC content: 51.29

Gene sequence:

>813_bases
ATGCTTCGCGAAGATGTCCCGTATTTCGATCTGACAAGCCGGATCATGGACCTGGAAACCATCGAAGCAGAAATTCTTTT
TACGCCCAAAAGTGACGTCACCGTTTGCGGAACCGAAGAAGCGGAAAAAATTTTCGGCATGCTGGGTGCCGAAACATCTC
TGCTCAAAAAAAGCGGCGAACATGCAGGTCAAGACCAGACCGTTTTCAGAGCGTACGGCAATGCCGAACAACTGCATATG
GGCTGGAAAGTCGTGCAGAATATTCTTGAACACTTCTCTGGAATTGCCACACGAACCCGTTCCATGGTCGATGGGGCAAA
CAGGGGGAAACCGAACACCGAAGTGTGCGGGACAAGGAAACATCTTCCAGGCATCAAACACCTCTCCCTGAAAGCCCTCT
GCGCCGGGGGAGGCTATCCTCATCGCCTTGGCATATCGGATTCCGTTCTTATTTTCTCGAACCACTACGACCTGCTTGGC
GGGATCGGTGCCGTCTGCCGGGAACTGCCATCCATCAGGTCACGATGTCCCGAAAAAAAAGTTGCCGTAGAAGTTGAGAC
GCTCGATCATGCCGTTATGGCAGCAGAAGCCGGAGCAGATATCATCCAGCTCGACAAACTCAAACCGGAAGCTGTAGAAA
AGATCGTCAACACCATAAAGCCGTCACACCGTCATATCGTTATAGCTGCTGCTGGAGGAGTCAATGCTTCCAACGCTGAA
GCCTATGGGGCTGCCGGAGCAGATGTTCTGGTCAGCTCATGGATGTATTTCGGCAAACCTGTCGATTACAAGGTTGTTGT
CCGAAAAGTATGA

Upstream 100 bases:

>100_bases
AGAGTCGGCCTACAATCAAGGCCACTTGCTGTCCTTGAAAATTTCAATCAAAGAAGAAACAACCGTGCAATTCATAACAA
ACCTTTCTGAAACAGAAGCC

Downstream 100 bases:

>100_bases
CATCCGAAATGCAGAAAAAACAAAACCTGCTCTGAACCAGATGTCCAGAGCAGGTGTAACGGAGAAGAAGCAACACATAC
TTCTTTTATAACAACAAAGC

Product: modD protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLREDVPYFDLTSRIMDLETIEAEILFTPKSDVTVCGTEEAEKIFGMLGAETSLLKKSGEHAGQDQTVFRAYGNAEQLHM
GWKVVQNILEHFSGIATRTRSMVDGANRGKPNTEVCGTRKHLPGIKHLSLKALCAGGGYPHRLGISDSVLIFSNHYDLLG
GIGAVCRELPSIRSRCPEKKVAVEVETLDHAVMAAEAGADIIQLDKLKPEAVEKIVNTIKPSHRHIVIAAAGGVNASNAE
AYGAAGADVLVSSWMYFGKPVDYKVVVRKV

Sequences:

>Translated_270_residues
MLREDVPYFDLTSRIMDLETIEAEILFTPKSDVTVCGTEEAEKIFGMLGAETSLLKKSGEHAGQDQTVFRAYGNAEQLHM
GWKVVQNILEHFSGIATRTRSMVDGANRGKPNTEVCGTRKHLPGIKHLSLKALCAGGGYPHRLGISDSVLIFSNHYDLLG
GIGAVCRELPSIRSRCPEKKVAVEVETLDHAVMAAEAGADIIQLDKLKPEAVEKIVNTIKPSHRHIVIAAAGGVNASNAE
AYGAAGADVLVSSWMYFGKPVDYKVVVRKV
>Mature_270_residues
MLREDVPYFDLTSRIMDLETIEAEILFTPKSDVTVCGTEEAEKIFGMLGAETSLLKKSGEHAGQDQTVFRAYGNAEQLHM
GWKVVQNILEHFSGIATRTRSMVDGANRGKPNTEVCGTRKHLPGIKHLSLKALCAGGGYPHRLGISDSVLIFSNHYDLLG
GIGAVCRELPSIRSRCPEKKVAVEVETLDHAVMAAEAGADIIQLDKLKPEAVEKIVNTIKPSHRHIVIAAAGGVNASNAE
AYGAAGADVLVSSWMYFGKPVDYKVVVRKV

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=249, Percent_Identity=28.9156626506024, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786299, Length=257, Percent_Identity=26.8482490272374, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321162, Length=272, Percent_Identity=29.7794117647059, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.-

Molecular weight: Translated: 29254; Mature: 29254

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLREDVPYFDLTSRIMDLETIEAEILFTPKSDVTVCGTEEAEKIFGMLGAETSLLKKSGE
CCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEECCHHHHHHHHHHCCHHHHHHHCCC
HAGQDQTVFRAYGNAEQLHMGWKVVQNILEHFSGIATRTRSMVDGANRGKPNTEVCGTRK
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
HLPGIKHLSLKALCAGGGYPHRLGISDSVLIFSNHYDLLGGIGAVCRELPSIRSRCPEKK
HCCCCCHHHHEEEECCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
VAVEVETLDHAVMAAEAGADIIQLDKLKPEAVEKIVNTIKPSHRHIVIAAAGGVNASNAE
EEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
AYGAAGADVLVSSWMYFGKPVDYKVVVRKV
CCCCCCHHHHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MLREDVPYFDLTSRIMDLETIEAEILFTPKSDVTVCGTEEAEKIFGMLGAETSLLKKSGE
CCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEECCHHHHHHHHHHCCHHHHHHHCCC
HAGQDQTVFRAYGNAEQLHMGWKVVQNILEHFSGIATRTRSMVDGANRGKPNTEVCGTRK
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
HLPGIKHLSLKALCAGGGYPHRLGISDSVLIFSNHYDLLGGIGAVCRELPSIRSRCPEKK
HCCCCCHHHHEEEECCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
VAVEVETLDHAVMAAEAGADIIQLDKLKPEAVEKIVNTIKPSHRHIVIAAAGGVNASNAE
EEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
AYGAAGADVLVSSWMYFGKPVDYKVVVRKV
CCCCCCHHHHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]