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The map label for this gene is polC [H]

Identifier: 193212627

GI number: 193212627

Start: 1075483

End: 1076181

Strand: Direct

Name: polC [H]

Synonym: Cpar_0972

Alternate gene names: 193212627

Gene position: 1075483-1076181 (Clockwise)

Preceding gene: 193212626

Following gene: 193212633

Centisome position: 46.98

GC content: 58.37

Gene sequence:

>699_bases
GTGATTGAGCTGATCCAGAAAAAGCTGCTCTTGCGGAAGTGCCGGAACGGAGAGCTGCCGGAGAGCGTCTGCCGCTACCT
GCACCGGTTCGACGAAGGCTTTCGCGCACAGACGCCGATAGAGGATGCGCGTTTCGTCATTTACGATACCGAAACCACCG
GATTCGATTTCAGGCATGACCGGATCATTTCGATCGGCGCGGTCGGCACGAAAGGGGAGGTGATCGATATCGCCGATTCG
TTCGAGGTGCTGCTTCGTCAGGAGGTGTGCAGCGAGCGCGATGCGGTGACGGTGCATGGCCTGCTCAAGCGCGATATCGA
CAGCGGTCTGGAAGAGAGCGAGGCGGTTTGCCGTTTTCTGGACTATCTCGGCAATGCGGTGATCGTGGCGCATCATGCCG
ATTTCGATATCGCCATGATCAATCAGGTGCTTTCGAGGCGCTTCGGAATGCGGCTCTTCAACGAAGCTCTCGATACGGCC
AGCTTTGCCAAACGGCTTGAAAAAGGTCCCTACTACAACCTTGCGCATAAGGGTGGTGAGTACCGCCTTGACAACCTCTG
CGCCCGTTACGGCATCCGCCTCTACGACCGCCACACCGCACCAGGGGACGCCTACCTTACCGCCCAGCTTTTCCAGCGCC
TTCTCGCGCTTGGCCGCAAAGCGGGTATCGATACGCTCGGCAAGCTCTTGCTGAAGTGA

Upstream 100 bases:

>100_bases
GGGCTTAACAAGATCGAACGCCAGATGCTCAGAAACGTCTTTTCAACCATCGGCAAGGTGCAGAGCATGCTCAACCTCCG
GTTCCAGCTCGACTACATCC

Downstream 100 bases:

>100_bases
CGTTGCCGCGGCAAAAAGTCCAGGACAATCCAGATTGAAATCGGAATCGGAAGGCTCGTTCGTCAGGAGACGGCCGGTTT
GCGGGCAAGCAGCATCATGC

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MIELIQKKLLLRKCRNGELPESVCRYLHRFDEGFRAQTPIEDARFVIYDTETTGFDFRHDRIISIGAVGTKGEVIDIADS
FEVLLRQEVCSERDAVTVHGLLKRDIDSGLEESEAVCRFLDYLGNAVIVAHHADFDIAMINQVLSRRFGMRLFNEALDTA
SFAKRLEKGPYYNLAHKGGEYRLDNLCARYGIRLYDRHTAPGDAYLTAQLFQRLLALGRKAGIDTLGKLLLK

Sequences:

>Translated_232_residues
MIELIQKKLLLRKCRNGELPESVCRYLHRFDEGFRAQTPIEDARFVIYDTETTGFDFRHDRIISIGAVGTKGEVIDIADS
FEVLLRQEVCSERDAVTVHGLLKRDIDSGLEESEAVCRFLDYLGNAVIVAHHADFDIAMINQVLSRRFGMRLFNEALDTA
SFAKRLEKGPYYNLAHKGGEYRLDNLCARYGIRLYDRHTAPGDAYLTAQLFQRLLALGRKAGIDTLGKLLLK
>Mature_232_residues
MIELIQKKLLLRKCRNGELPESVCRYLHRFDEGFRAQTPIEDARFVIYDTETTGFDFRHDRIISIGAVGTKGEVIDIADS
FEVLLRQEVCSERDAVTVHGLLKRDIDSGLEESEAVCRFLDYLGNAVIVAHHADFDIAMINQVLSRRFGMRLFNEALDTA
SFAKRLEKGPYYNLAHKGGEYRLDNLCARYGIRLYDRHTAPGDAYLTAQLFQRLLALGRKAGIDTLGKLLLK

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 26386; Mature: 26386

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQKKLLLRKCRNGELPESVCRYLHRFDEGFRAQTPIEDARFVIYDTETTGFDFRHD
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
RIISIGAVGTKGEVIDIADSFEVLLRQEVCSERDAVTVHGLLKRDIDSGLEESEAVCRFL
CEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
DYLGNAVIVAHHADFDIAMINQVLSRRFGMRLFNEALDTASFAKRLEKGPYYNLAHKGGE
HHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCC
YRLDNLCARYGIRLYDRHTAPGDAYLTAQLFQRLLALGRKAGIDTLGKLLLK
CHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MIELIQKKLLLRKCRNGELPESVCRYLHRFDEGFRAQTPIEDARFVIYDTETTGFDFRHD
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
RIISIGAVGTKGEVIDIADSFEVLLRQEVCSERDAVTVHGLLKRDIDSGLEESEAVCRFL
CEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
DYLGNAVIVAHHADFDIAMINQVLSRRFGMRLFNEALDTASFAKRLEKGPYYNLAHKGGE
HHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCC
YRLDNLCARYGIRLYDRHTAPGDAYLTAQLFQRLLALGRKAGIDTLGKLLLK
CHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]