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The map label for this gene is cfiA [H]

Identifier: 193212520

GI number: 193212520

Start: 937427

End: 939310

Strand: Direct

Name: cfiA [H]

Synonym: Cpar_0858

Alternate gene names: 193212520

Gene position: 937427-939310 (Clockwise)

Preceding gene: 193212519

Following gene: 193212521

Centisome position: 40.95

GC content: 61.15

Gene sequence:

>1884_bases
ATGAAAAAAATACGGTTCATGGATGTCTCCTTCCGCGACGGGTTCCAGTCCTGTTACGGAGCAAGGGTCAAAACCGAGGA
TTTCCTTCCGGTGCTTCAGGCTGCGGTCGATGCGGGCACCGATAACTTCGAGGTGGGCGGCGGCGCACGCTTCCAGAGCC
TCTACTTCTACTGCCAGGAGGACGCCTTCGAGATGATGGATGCCTGCCGCCGCGTGGTCGGGCCGGACATCAACCTCCAG
ACTCTGTCGCGAGGTGCAAACGTGGTGGGTCTCGTGTCGCAGTCGCGTGACATCATCGACCTTCACGCCAAGCTTTTCAA
GAAGCACGGCATCAGCACCATCCGCAACTTCGACGCGCTCATGGATGTGCGCAACCTCGCATGGTCGGGTCAGTGCATCG
TCAACGCCGGGCTGAAGCACCAGGTGGTGATCGCCCTGATGGGTCTGCCTCCGGGCCTCAAGGAGTCGTACTGCCACACG
CCGCAGTTCTACCTCGACAAGCTCAAGGATATTCTCGATGCGGGTATTCCGTTCGATAGCGTCGCTTTCAAGGACGCCTC
TGGCACCACCACTCCCGCCGTCGTGTACGAAACGGTCAAGGGTGCGCGCAAAATGCTGCCCGAGGGCACCACGCTCGAAT
TCCACACGCACGACACCGCTGGAATGGGCGTGGCGTGTAACTACGCTGCTATCGAGGCCGGTATCGACATCATCGACCTT
GCGATGGCTCCGGTCAGCGGTGGCACCGCCGAGGTTGACATTCTCACCATGTGGCACCGCCTGCGTGGCACCGACTACAC
CCTCGACATCGACCAGGAGAAGTACCTCGAAGTCGAGCGGATGTTCATCGAGCACATGGACAAATACTACATGCCGCCGG
AAGCCAAAGAGGTCAATCCGGTGATTCCGTTCTCCCCGATGCCCGGCGGCGCGCTGACCGCCAACACCCAGATGATGCGC
GACCACGACACGCTGCACTTCTTCCCCGAGGTGATCCGCAACATGCGCGAAGTTGTCGCCAAGGGCGGCTTCGGCGCTTC
GGTGACGCCGGTTTCGCAGTTCTACTTCCAGCAGGCTTTCGCCAACACCGTGCAGGGGCCGTGGAAAAAGATCGTGGACG
GCTACGGCAAGATGGTGCTCGGCTACTTCGGCAAGACCCCGGCAGCCCCCGATCCGGAGGTGGTGGCGCTCGCCTCGGAA
CAGCTCGGCCTCGAGCCGACCGTTCAGGACGTGCACGACATCAACGACCGCAATCCCGATCTTGGCATCGAGCACAACAC
CAAGCTGCTCGAAGAGGCAGGTCTGGAGATTACCGACGAAAACATCTTCATCGCGGCTACCTGCGGCGCGAAGGGCATCG
GTTTCCTTCAGGGCGACAAGCCGATGGGCATCCGCTACAAGGCGGATATCGAGGCTGAGGAGGAGGCCAAGCATAGCGAG
GAAGAGTTGAAGGTCACCTCGCACGGCAACTCGTTGCAGGATCGCTTGTCTGACCTCATCAAACCGGCTGGCCGCAGCAA
TCTGTCGGGCAACTACATGGTGATGGTCGATGGCAAGTCGTTCAACGTGGTGATCGCCGACGGCATGGTGATGGCGCAGT
CCACCGCCCCCGGCGCGCAGCCGATGGCGATGCCGCAAATGGCCGCTCCCGCCGCTGTCCAGCAGCACCAGGGCACACCC
GTGATGCCGTCAATGCCGGGCAACGTCTTCAAGATGGAAGTCGAAGTCGGCCAGAAGGTCGAGGAAGGCCAGGAGGTCGC
CGTCATGGAGGCTATGAAGATGGAGTCCCCGGTCAAGGCCCCCAAGTCGGGCATCGTCACGGTAGTCCTCGCCAAACCGG
GCGATGCGGTTTCCGCCGACCAGCCGCTGATGTATATCGATTGA

Upstream 100 bases:

>100_bases
ACGATCACGGCTGAGCCGGATCAATCATTTTTCGAGGCTGTTTGCCTGCTTGGCGGGAGGCGGCCCTAACGGATCAAGAT
AAAACCAACGAGAGCGTTAT

Downstream 100 bases:

>100_bases
TCTGGAAGCGATTTATCATAGCACTATTCAAAAGGGCAGACTTAACAGGTCTGCCCTTTTTTTGTTTGCTGATCAAGTGA
TAAATTTGGTGTAATGGTTT

Product: Oxaloacetate decarboxylase

Products: NA

Alternate protein names: 2-oxoglutarate carboxylase alpha subunit [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MKKIRFMDVSFRDGFQSCYGARVKTEDFLPVLQAAVDAGTDNFEVGGGARFQSLYFYCQEDAFEMMDACRRVVGPDINLQ
TLSRGANVVGLVSQSRDIIDLHAKLFKKHGISTIRNFDALMDVRNLAWSGQCIVNAGLKHQVVIALMGLPPGLKESYCHT
PQFYLDKLKDILDAGIPFDSVAFKDASGTTTPAVVYETVKGARKMLPEGTTLEFHTHDTAGMGVACNYAAIEAGIDIIDL
AMAPVSGGTAEVDILTMWHRLRGTDYTLDIDQEKYLEVERMFIEHMDKYYMPPEAKEVNPVIPFSPMPGGALTANTQMMR
DHDTLHFFPEVIRNMREVVAKGGFGASVTPVSQFYFQQAFANTVQGPWKKIVDGYGKMVLGYFGKTPAAPDPEVVALASE
QLGLEPTVQDVHDINDRNPDLGIEHNTKLLEEAGLEITDENIFIAATCGAKGIGFLQGDKPMGIRYKADIEAEEEAKHSE
EELKVTSHGNSLQDRLSDLIKPAGRSNLSGNYMVMVDGKSFNVVIADGMVMAQSTAPGAQPMAMPQMAAPAAVQQHQGTP
VMPSMPGNVFKMEVEVGQKVEEGQEVAVMEAMKMESPVKAPKSGIVTVVLAKPGDAVSADQPLMYID

Sequences:

>Translated_627_residues
MKKIRFMDVSFRDGFQSCYGARVKTEDFLPVLQAAVDAGTDNFEVGGGARFQSLYFYCQEDAFEMMDACRRVVGPDINLQ
TLSRGANVVGLVSQSRDIIDLHAKLFKKHGISTIRNFDALMDVRNLAWSGQCIVNAGLKHQVVIALMGLPPGLKESYCHT
PQFYLDKLKDILDAGIPFDSVAFKDASGTTTPAVVYETVKGARKMLPEGTTLEFHTHDTAGMGVACNYAAIEAGIDIIDL
AMAPVSGGTAEVDILTMWHRLRGTDYTLDIDQEKYLEVERMFIEHMDKYYMPPEAKEVNPVIPFSPMPGGALTANTQMMR
DHDTLHFFPEVIRNMREVVAKGGFGASVTPVSQFYFQQAFANTVQGPWKKIVDGYGKMVLGYFGKTPAAPDPEVVALASE
QLGLEPTVQDVHDINDRNPDLGIEHNTKLLEEAGLEITDENIFIAATCGAKGIGFLQGDKPMGIRYKADIEAEEEAKHSE
EELKVTSHGNSLQDRLSDLIKPAGRSNLSGNYMVMVDGKSFNVVIADGMVMAQSTAPGAQPMAMPQMAAPAAVQQHQGTP
VMPSMPGNVFKMEVEVGQKVEEGQEVAVMEAMKMESPVKAPKSGIVTVVLAKPGDAVSADQPLMYID
>Mature_627_residues
MKKIRFMDVSFRDGFQSCYGARVKTEDFLPVLQAAVDAGTDNFEVGGGARFQSLYFYCQEDAFEMMDACRRVVGPDINLQ
TLSRGANVVGLVSQSRDIIDLHAKLFKKHGISTIRNFDALMDVRNLAWSGQCIVNAGLKHQVVIALMGLPPGLKESYCHT
PQFYLDKLKDILDAGIPFDSVAFKDASGTTTPAVVYETVKGARKMLPEGTTLEFHTHDTAGMGVACNYAAIEAGIDIIDL
AMAPVSGGTAEVDILTMWHRLRGTDYTLDIDQEKYLEVERMFIEHMDKYYMPPEAKEVNPVIPFSPMPGGALTANTQMMR
DHDTLHFFPEVIRNMREVVAKGGFGASVTPVSQFYFQQAFANTVQGPWKKIVDGYGKMVLGYFGKTPAAPDPEVVALASE
QLGLEPTVQDVHDINDRNPDLGIEHNTKLLEEAGLEITDENIFIAATCGAKGIGFLQGDKPMGIRYKADIEAEEEAKHSE
EELKVTSHGNSLQDRLSDLIKPAGRSNLSGNYMVMVDGKSFNVVIADGMVMAQSTAPGAQPMAMPQMAAPAAVQQHQGTP
VMPSMPGNVFKMEVEVGQKVEEGQEVAVMEAMKMESPVKAPKSGIVTVVLAKPGDAVSADQPLMYID

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=664, Percent_Identity=25.3012048192771, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI106049295, Length=664, Percent_Identity=25.3012048192771, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI106049292, Length=664, Percent_Identity=25.3012048192771, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562816, Length=646, Percent_Identity=26.7801857585139, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319695, Length=650, Percent_Identity=26.1538461538462, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6321376, Length=650, Percent_Identity=25.0769230769231, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24652212, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652210, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652214, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19921944, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652216, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363050, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652224, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652222, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652220, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652218, Length=649, Percent_Identity=25.8859784283513, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.7 [H]

Molecular weight: Translated: 68423; Mature: 68423

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIRFMDVSFRDGFQSCYGARVKTEDFLPVLQAAVDAGTDNFEVGGGARFQSLYFYCQE
CCCEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCCEEEHEEEEEHH
DAFEMMDACRRVVGPDINLQTLSRGANVVGLVSQSRDIIDLHAKLFKKHGISTIRNFDAL
HHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHH
MDVRNLAWSGQCIVNAGLKHQVVIALMGLPPGLKESYCHTPQFYLDKLKDILDAGIPFDS
HHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCC
VAFKDASGTTTPAVVYETVKGARKMLPEGTTLEFHTHDTAGMGVACNYAAIEAGIDIIDL
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECHHHHHCCCCEEEE
AMAPVSGGTAEVDILTMWHRLRGTDYTLDIDQEKYLEVERMFIEHMDKYYMPPEAKEVNP
EECCCCCCCCEEHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VIPFSPMPGGALTANTQMMRDHDTLHFFPEVIRNMREVVAKGGFGASVTPVSQFYFQQAF
CCCCCCCCCCCEECCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ANTVQGPWKKIVDGYGKMVLGYFGKTPAAPDPEVVALASEQLGLEPTVQDVHDINDRNPD
HHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHCCCCCCC
LGIEHNTKLLEEAGLEITDENIFIAATCGAKGIGFLQGDKPMGIRYKADIEAEEEAKHSE
CCCCCCHHHHHHCCCEEECCCEEEEEECCCCCCEEEECCCCCCEEEEECCCCHHHHHCCH
EELKVTSHGNSLQDRLSDLIKPAGRSNLSGNYMVMVDGKSFNVVIADGMVMAQSTAPGAQ
HHEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCEEEEECCCCCCC
PMAMPQMAAPAAVQQHQGTPVMPSMPGNVFKMEVEVGQKVEEGQEVAVMEAMKMESPVKA
CCCCCHHCCCHHHHHCCCCCCCCCCCCCEEEEEEHHCCHHHCCCHHHHHHHHHHCCCCCC
PKSGIVTVVLAKPGDAVSADQPLMYID
CCCCEEEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure
MKKIRFMDVSFRDGFQSCYGARVKTEDFLPVLQAAVDAGTDNFEVGGGARFQSLYFYCQE
CCCEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCCEEEHEEEEEHH
DAFEMMDACRRVVGPDINLQTLSRGANVVGLVSQSRDIIDLHAKLFKKHGISTIRNFDAL
HHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHH
MDVRNLAWSGQCIVNAGLKHQVVIALMGLPPGLKESYCHTPQFYLDKLKDILDAGIPFDS
HHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCC
VAFKDASGTTTPAVVYETVKGARKMLPEGTTLEFHTHDTAGMGVACNYAAIEAGIDIIDL
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECHHHHHCCCCEEEE
AMAPVSGGTAEVDILTMWHRLRGTDYTLDIDQEKYLEVERMFIEHMDKYYMPPEAKEVNP
EECCCCCCCCEEHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VIPFSPMPGGALTANTQMMRDHDTLHFFPEVIRNMREVVAKGGFGASVTPVSQFYFQQAF
CCCCCCCCCCCEECCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ANTVQGPWKKIVDGYGKMVLGYFGKTPAAPDPEVVALASEQLGLEPTVQDVHDINDRNPD
HHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHCCCCCCC
LGIEHNTKLLEEAGLEITDENIFIAATCGAKGIGFLQGDKPMGIRYKADIEAEEEAKHSE
CCCCCCHHHHHHCCCEEECCCEEEEEECCCCCCEEEECCCCCCEEEEECCCCHHHHHCCH
EELKVTSHGNSLQDRLSDLIKPAGRSNLSGNYMVMVDGKSFNVVIADGMVMAQSTAPGAQ
HHEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCEEEEECCCCCCC
PMAMPQMAAPAAVQQHQGTPVMPSMPGNVFKMEVEVGQKVEEGQEVAVMEAMKMESPVKA
CCCCCHHCCCHHHHHCCCCCCCCCCCCCEEEEEEHHCCHHHCCCHHHHHHHHHHCCCCCC
PKSGIVTVVLAKPGDAVSADQPLMYID
CCCCEEEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA