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The map label for this gene is fumA [H]

Identifier: 193212519

GI number: 193212519

Start: 935801

End: 937327

Strand: Direct

Name: fumA [H]

Synonym: Cpar_0857

Alternate gene names: 193212519

Gene position: 935801-937327 (Clockwise)

Preceding gene: 193212518

Following gene: 193212520

Centisome position: 40.88

GC content: 61.89

Gene sequence:

>1527_bases
ATGAAACAGTTCAGGGATTCAATGATAGCCTTGATTACGGAGACCTCCGCCAACCTGCCGAGCGACGTGCGCAAGGCGAT
TGCCGATGCGGTCGGTCAGGAGACCGCCGATTCGAGAGCCGGTCTGGCCATGTCGGCCATCACGCTCAACATCGACATGG
CTGTCGATAACGTCGGCCCGGTCTGTCAGGATACCGGCATGCCCACCTTTTTCGTGCACACTCCGAAAGGCGTCGATCAG
CTCGCCATGAAGCGCGACATCGAAGAGGCTATCGTCGAGGCGACCCGCACCGGCAAGCTTCGCCCCAATGCGGTTGATTC
GATGAGCGGCAAGAACTCCGGCAACAACCTCGGCTGCCACGTGCCGGTGATCCATTTCGAACCGTGGGATCGCGACGAGA
TCGAGGTGAAGCTTATCCTCAAAGGCGGCGGCTGCGAGAACAAGAACATCCAGTATTCGCTTCCGGCTGAAATTCCCGGA
CAGGGCCGTGCGGCTCGCGACATCGACGGCGTGCGCAAGTGCATCGCCCACGCGGTGTACCAGGCGCAGGGGCAGGGGTG
CAGCCCTGGTTTCATCGGCGTCGGCGTCGGCGGCGACCGCACCAGCGGCTTCGAGCTGGCCAAGAAGCAGCTTCTCCGTT
ATGTCGATGACACCAATCCCGATCCGGAACTGGCTGGCCTCGAACAGGAGATGCTCGAAAAGGCCAACACGCTGAACATT
GGCCCGATGGGCTTCTCCGGCAAGAGCACGCTGCTCGGCTGCAAGATCGGCAAGTCGCACCGAGTGCCGGCCAGCTTCTT
CGTCTCGGTGGCCTACAACTGCTGGGCTTACCGCCGTCTCGGCGTCATCATCGATCCCGCAGAGGGCTCGATCACCGAGT
GGCAGTACCGTTCCGACGATGAAATCAAACGCATGGCTCAGGGCGAGGGCATTCCGCTTACGGGCCGCGAGGTGGTGCTC
AAGGCTCCGATCAGCGAGGAGACGATCCGCTCGCTCAAGGTGGGCGACATCGTCATCGTCGAGGGCGAGATGCACACCGG
CCGCGACGCCTTCCACCACTACGTGATGCACCACGACCTGCCGGAGGATCTCGACATCAGTGGCGGCATTATCTACCACT
GCGGCCCGGTGATGCTCAAGAACGACGATGGTGAGTACCGGGTTGTCGCCGCAGGGCCGACCACCTCGATCCGCGAGGAG
CCCTACCAGGCGGACGTGATCGAGAAGCTCGGCCTTCGCGCTGTGATCGGCAAGGGCGGCATGGGGCCGAAGACGCTGGC
CGGCCTGCAGAAGCATGGCGCGGTGTACCTCAACGCCATCGGCGGTGCGGCACAGTACTACGCCCGCTCGGTAGAAAAGG
TGACCGGCGTCGATTTTCTCGAAGAGATGGGTGTGCCAGAAGCGATGTGGCACTTGCAGGTCAAGGCATTCCCGGCAATC
GTCACGATGGACGCCAACGGTAACAGCCTGCACCAGCAGGTCGATGAGGAGTCGTTCGCGATTCTCGAAAAGATCGGCAA
AGAGTAA

Upstream 100 bases:

>100_bases
CGACAAAACTGCTACTGAATAAGCGATTTATCAGCGGGGTTTCTCTGGACGCGATCCGGGCGGCCTCAACTACTATTGTT
CACTTTCAAGCTTCCCGATT

Downstream 100 bases:

>100_bases
CGATCACGGCTGAGCCGGATCAATCATTTTTCGAGGCTGTTTGCCTGCTTGGCGGGAGGCGGCCCTAACGGATCAAGATA
AAACCAACGAGAGCGTTATA

Product: hydro-lyase, Fe-S type, tartrate/fumarate subfamily subunit alpha

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKQFRDSMIALITETSANLPSDVRKAIADAVGQETADSRAGLAMSAITLNIDMAVDNVGPVCQDTGMPTFFVHTPKGVDQ
LAMKRDIEEAIVEATRTGKLRPNAVDSMSGKNSGNNLGCHVPVIHFEPWDRDEIEVKLILKGGGCENKNIQYSLPAEIPG
QGRAARDIDGVRKCIAHAVYQAQGQGCSPGFIGVGVGGDRTSGFELAKKQLLRYVDDTNPDPELAGLEQEMLEKANTLNI
GPMGFSGKSTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGVIIDPAEGSITEWQYRSDDEIKRMAQGEGIPLTGREVVL
KAPISEETIRSLKVGDIVIVEGEMHTGRDAFHHYVMHHDLPEDLDISGGIIYHCGPVMLKNDDGEYRVVAAGPTTSIREE
PYQADVIEKLGLRAVIGKGGMGPKTLAGLQKHGAVYLNAIGGAAQYYARSVEKVTGVDFLEEMGVPEAMWHLQVKAFPAI
VTMDANGNSLHQQVDEESFAILEKIGKE

Sequences:

>Translated_508_residues
MKQFRDSMIALITETSANLPSDVRKAIADAVGQETADSRAGLAMSAITLNIDMAVDNVGPVCQDTGMPTFFVHTPKGVDQ
LAMKRDIEEAIVEATRTGKLRPNAVDSMSGKNSGNNLGCHVPVIHFEPWDRDEIEVKLILKGGGCENKNIQYSLPAEIPG
QGRAARDIDGVRKCIAHAVYQAQGQGCSPGFIGVGVGGDRTSGFELAKKQLLRYVDDTNPDPELAGLEQEMLEKANTLNI
GPMGFSGKSTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGVIIDPAEGSITEWQYRSDDEIKRMAQGEGIPLTGREVVL
KAPISEETIRSLKVGDIVIVEGEMHTGRDAFHHYVMHHDLPEDLDISGGIIYHCGPVMLKNDDGEYRVVAAGPTTSIREE
PYQADVIEKLGLRAVIGKGGMGPKTLAGLQKHGAVYLNAIGGAAQYYARSVEKVTGVDFLEEMGVPEAMWHLQVKAFPAI
VTMDANGNSLHQQVDEESFAILEKIGKE
>Mature_508_residues
MKQFRDSMIALITETSANLPSDVRKAIADAVGQETADSRAGLAMSAITLNIDMAVDNVGPVCQDTGMPTFFVHTPKGVDQ
LAMKRDIEEAIVEATRTGKLRPNAVDSMSGKNSGNNLGCHVPVIHFEPWDRDEIEVKLILKGGGCENKNIQYSLPAEIPG
QGRAARDIDGVRKCIAHAVYQAQGQGCSPGFIGVGVGGDRTSGFELAKKQLLRYVDDTNPDPELAGLEQEMLEKANTLNI
GPMGFSGKSTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGVIIDPAEGSITEWQYRSDDEIKRMAQGEGIPLTGREVVL
KAPISEETIRSLKVGDIVIVEGEMHTGRDAFHHYVMHHDLPEDLDISGGIIYHCGPVMLKNDDGEYRVVAAGPTTSIREE
PYQADVIEKLGLRAVIGKGGMGPKTLAGLQKHGAVYLNAIGGAAQYYARSVEKVTGVDFLEEMGVPEAMWHLQVKAFPAI
VTMDANGNSLHQQVDEESFAILEKIGKE

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=173, Percent_Identity=38.728323699422, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789442, Length=269, Percent_Identity=30.1115241635688, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787897, Length=477, Percent_Identity=25.7861635220126, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790564, Length=482, Percent_Identity=25.9336099585062, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 55013; Mature: 55013

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFRDSMIALITETSANLPSDVRKAIADAVGQETADSRAGLAMSAITLNIDMAVDNVGP
CCHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEECCCCC
VCQDTGMPTFFVHTPKGVDQLAMKRDIEEAIVEATRTGKLRPNAVDSMSGKNSGNNLGCH
CHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCEEE
VPVIHFEPWDRDEIEVKLILKGGGCENKNIQYSLPAEIPGQGRAARDIDGVRKCIAHAVY
EEEEEECCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
QAQGQGCSPGFIGVGVGGDRTSGFELAKKQLLRYVDDTNPDPELAGLEQEMLEKANTLNI
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCC
GPMGFSGKSTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGVIIDPAEGSITEWQYRSDD
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHEEEEECEEEECCCCCEEECCCCCHH
EIKRMAQGEGIPLTGREVVLKAPISEETIRSLKVGDIVIVEGEMHTGRDAFHHYVMHHDL
HHHHHHCCCCCCCCCCCEEEECCCCHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHCCC
PEDLDISGGIIYHCGPVMLKNDDGEYRVVAAGPTTSIREEPYQADVIEKLGLRAVIGKGG
CCCCCCCCCEEEECCEEEEECCCCCEEEEEECCCCCHHCCCCHHHHHHHCCCEEEECCCC
MGPKTLAGLQKHGAVYLNAIGGAAQYYARSVEKVTGVDFLEEMGVPEAMWHLQVKAFPAI
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCEE
VTMDANGNSLHQQVDEESFAILEKIGKE
EEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQFRDSMIALITETSANLPSDVRKAIADAVGQETADSRAGLAMSAITLNIDMAVDNVGP
CCHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEECCCCC
VCQDTGMPTFFVHTPKGVDQLAMKRDIEEAIVEATRTGKLRPNAVDSMSGKNSGNNLGCH
CHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCEEE
VPVIHFEPWDRDEIEVKLILKGGGCENKNIQYSLPAEIPGQGRAARDIDGVRKCIAHAVY
EEEEEECCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
QAQGQGCSPGFIGVGVGGDRTSGFELAKKQLLRYVDDTNPDPELAGLEQEMLEKANTLNI
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCC
GPMGFSGKSTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGVIIDPAEGSITEWQYRSDD
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHEEEEECEEEECCCCCEEECCCCCHH
EIKRMAQGEGIPLTGREVVLKAPISEETIRSLKVGDIVIVEGEMHTGRDAFHHYVMHHDL
HHHHHHCCCCCCCCCCCEEEECCCCHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHCCC
PEDLDISGGIIYHCGPVMLKNDDGEYRVVAAGPTTSIREEPYQADVIEKLGLRAVIGKGG
CCCCCCCCCEEEECCEEEEECCCCCEEEEEECCCCCHHCCCCHHHHHHHCCCEEEECCCC
MGPKTLAGLQKHGAVYLNAIGGAAQYYARSVEKVTGVDFLEEMGVPEAMWHLQVKAFPAI
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCEE
VTMDANGNSLHQQVDEESFAILEKIGKE
EEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473853 [H]