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The map label for this gene is folD [H]

Identifier: 193212353

GI number: 193212353

Start: 732555

End: 733445

Strand: Direct

Name: folD [H]

Synonym: Cpar_0686

Alternate gene names: 193212353

Gene position: 732555-733445 (Clockwise)

Preceding gene: 193212351

Following gene: 193212354

Centisome position: 32.0

GC content: 57.91

Gene sequence:

>891_bases
ATGAAAGCACTTGACCCGAGCCCAATCGCCGCCGCATTTCGTGATGCCGTCCGCCGGGAGATCAGCGATGAAAAGCTGAG
CATCAATATCGTCGGCATTCTGGCCTCCGATGATCCCGCATCGGCAACCTACGCAGACTACACTCGGGCGGGGTGTGAGG
ATGTCGGCATCAGCTTCGATCTGCGCAAAACCAGTCCCGAATCGGTCAGGAACATGCTTGAATCGGCCAATGCGGATTCA
GACGTTCACGGCATTTTCGTCTATTATCCGATCTGGGGCGACAGCCGCGATGCCGAGCTTCGTGACCTGATTTCGCCGCA
CAAGGATGTCGAGGGGCTCTGTCCGCACTGGATCAGCAAGCTCTACGCCAACGAGCGTTTCGACGATGAGGCGCGAAAGT
TCAAGGCGATTCTGCCCTGCACACCGCTGGCCATCCTCAAGCTGCTCGAAGAGACCGAGGCCTACATTCCCTACGGCTTG
CCGTTCGGCGGTCAGCAGATCACCATTTTCAACCGTTCGGAAGTGGTCGGCAGGCCGCTCGCCTACATGCTCTCAAACGA
CGGTGCGAGGGTCTATTCGTTCGACATCGACGGCGGCTTCGTGGTTGATGTCAACGATCCCGGCCACGAGCGCGTGCCAG
TTACCCGCGAGGAGGCGTTGAGACAGTCGGACATCGTGATTACCGGCGTGCCTTCAAAAGTGTTCGACAAGATCAAAGCC
GATGAGCTGAAGTCGGGCGCAGTTTGCCTGAACTTCTCTTCAATCCAGAATTTCGAGCCGGATGCCAAGGAATCGGCCGG
GCTCTACATTCCGAGGGTCGGCCCCATGACGGTGGCCATGTGCATGCGCAACGCCCTGCAACTCTATCGCAACTACCATC
ATGAAGCCTGA

Upstream 100 bases:

>100_bases
CGTTTCGGAAGCATTTCGGACAAAGCGCAGCGTGCTCCGTCGGAGTCACCATCCCTCTCTTTTGCCCGTACAGATTTGTC
ACACACAGCCTTGTTGATTC

Downstream 100 bases:

>100_bases
CGGTACGCTTGAATCGACCACCATTGCCGCCTACCTCGGTCGGCTCGCCAGCGGTGATCCCACGCCGGGTGGTGGGGCGG
CAGCGGCAGTGACGGCCGCA

Product: tetrahydrofolate dehydrogenase/cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKALDPSPIAAAFRDAVRREISDEKLSINIVGILASDDPASATYADYTRAGCEDVGISFDLRKTSPESVRNMLESANADS
DVHGIFVYYPIWGDSRDAELRDLISPHKDVEGLCPHWISKLYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGL
PFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGVPSKVFDKIKA
DELKSGAVCLNFSSIQNFEPDAKESAGLYIPRVGPMTVAMCMRNALQLYRNYHHEA

Sequences:

>Translated_296_residues
MKALDPSPIAAAFRDAVRREISDEKLSINIVGILASDDPASATYADYTRAGCEDVGISFDLRKTSPESVRNMLESANADS
DVHGIFVYYPIWGDSRDAELRDLISPHKDVEGLCPHWISKLYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGL
PFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGVPSKVFDKIKA
DELKSGAVCLNFSSIQNFEPDAKESAGLYIPRVGPMTVAMCMRNALQLYRNYHHEA
>Mature_296_residues
MKALDPSPIAAAFRDAVRREISDEKLSINIVGILASDDPASATYADYTRAGCEDVGISFDLRKTSPESVRNMLESANADS
DVHGIFVYYPIWGDSRDAELRDLISPHKDVEGLCPHWISKLYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGL
PFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGVPSKVFDKIKA
DELKSGAVCLNFSSIQNFEPDAKESAGLYIPRVGPMTVAMCMRNALQLYRNYHHEA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=326, Percent_Identity=26.9938650306748, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI94721354, Length=310, Percent_Identity=26.7741935483871, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI222418558, Length=276, Percent_Identity=26.4492753623188, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786741, Length=278, Percent_Identity=27.6978417266187, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17568735, Length=237, Percent_Identity=28.2700421940928, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322933, Length=304, Percent_Identity=39.4736842105263, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6319558, Length=311, Percent_Identity=25.4019292604502, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321643, Length=314, Percent_Identity=26.7515923566879, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136818, Length=286, Percent_Identity=25.8741258741259, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136816, Length=286, Percent_Identity=25.8741258741259, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 32881; Mature: 32881

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALDPSPIAAAFRDAVRREISDEKLSINIVGILASDDPASATYADYTRAGCEDVGISFD
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCHHHCCCEEE
LRKTSPESVRNMLESANADSDVHGIFVYYPIWGDSRDAELRDLISPHKDVEGLCPHWISK
ECCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCCHHHCCHHHHHH
LYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGLPFGGQQITIFNRSEVVGRPL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCC
AYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGVPSKVFDKIKA
EEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHH
DELKSGAVCLNFSSIQNFEPDAKESAGLYIPRVGPMTVAMCMRNALQLYRNYHHEA
HHCCCCEEEEEEHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKALDPSPIAAAFRDAVRREISDEKLSINIVGILASDDPASATYADYTRAGCEDVGISFD
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCHHHCCCEEE
LRKTSPESVRNMLESANADSDVHGIFVYYPIWGDSRDAELRDLISPHKDVEGLCPHWISK
ECCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCCHHHCCHHHHHH
LYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGLPFGGQQITIFNRSEVVGRPL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCC
AYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGVPSKVFDKIKA
EEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHH
DELKSGAVCLNFSSIQNFEPDAKESAGLYIPRVGPMTVAMCMRNALQLYRNYHHEA
HHCCCCEEEEEEHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA