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The map label for this gene is trpC

Identifier: 193212187

GI number: 193212187

Start: 556932

End: 557702

Strand: Direct

Name: trpC

Synonym: Cpar_0518

Alternate gene names: 193212187

Gene position: 556932-557702 (Clockwise)

Preceding gene: 193212186

Following gene: 193212194

Centisome position: 24.33

GC content: 58.11

Gene sequence:

>771_bases
ATGACGTACCTCACCCGGATTCTTGAGACCAAGGCCGAAGAGGTCGCCGAACTCAAAAAGCAGGACCCGGAACGCCGCTA
CCACGAAGCGTGCGGCGATCTTCCGGCGACGCGCGACTTTCGTTCGGCCATCACAAGCCTTGACGGTGGCATCAATCTCA
TCGCTGAAGTAAAAAAGGCATCGCCCTCGCGCGGGGTGCTTGTCGAGGATTTCCGCCCGCTCGACATTGCCGAACGCTAT
GCTGAAATTGGTGCGTCAGCCTTTTCCGTTCTCACTGATCGCCAGTATTTCCAGGGCTCGCCCGACTACCTGAAGGCGAT
CACGCAAAAGTTTTCCATTCCTGTGCTCCGCAAGGAGTTCATCATCGACGAGAGCCAGATTTACGAAACTCGCCTCATGG
GTGCCGATGCGGCGCTGTTGATCGTGGCGGCGCTCGAACCGTCGCAGTTGCGGGACTATCTTCAGCTTTTCGCCGAACTC
GGCCTGCACGCGCTGGTCGAAACGCATGACGAGCGCGAGCTCGACACCGCCCTTGAACAGGGCTCGACCATTGTTGGCGT
GAACAACCGCGATTTGAAAACCTTCACGGTCGACCTGATGACCTCCGTGCGGCTCAGGCAGCGGATGCCTGATGGCATCG
TTTCAGTAGCCGAAAGCGGCATGAAGCACCGTGACGATATTCAGATGATGCAGGAGGCCGGGTTTGATGCCGTTCTGATT
GGAGAGGGATTGCTCGTCAGCGAAGAGCTGCGGCAGTTCTCGTGGGGGTAG

Upstream 100 bases:

>100_bases
TCCATCAGGCAACCAGCATCGATCCGTGGTTCCTTGACAACATCCGCCAGATTGTCGAGTTCGAGGATGAGCTCCGCAAG
ATGGCAGCTGAAAGCGAGGC

Downstream 100 bases:

>100_bases
GCGTAGCGGTCGACTTGGTGGACAGCGCCGGGCTGTAAAACCAGCGTCTCCTTTCTTTTTTCCTATAGGACTTATAGGCC
CCATCAGACCTATAAGTCCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTYLTRILETKAEEVAELKKQDPERRYHEACGDLPATRDFRSAITSLDGGINLIAEVKKASPSRGVLVEDFRPLDIAERY
AEIGASAFSVLTDRQYFQGSPDYLKAITQKFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAEL
GLHALVETHDERELDTALEQGSTIVGVNNRDLKTFTVDLMTSVRLRQRMPDGIVSVAESGMKHRDDIQMMQEAGFDAVLI
GEGLLVSEELRQFSWG

Sequences:

>Translated_256_residues
MTYLTRILETKAEEVAELKKQDPERRYHEACGDLPATRDFRSAITSLDGGINLIAEVKKASPSRGVLVEDFRPLDIAERY
AEIGASAFSVLTDRQYFQGSPDYLKAITQKFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAEL
GLHALVETHDERELDTALEQGSTIVGVNNRDLKTFTVDLMTSVRLRQRMPDGIVSVAESGMKHRDDIQMMQEAGFDAVLI
GEGLLVSEELRQFSWG
>Mature_255_residues
TYLTRILETKAEEVAELKKQDPERRYHEACGDLPATRDFRSAITSLDGGINLIAEVKKASPSRGVLVEDFRPLDIAERYA
EIGASAFSVLTDRQYFQGSPDYLKAITQKFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELG
LHALVETHDERELDTALEQGSTIVGVNNRDLKTFTVDLMTSVRLRQRMPDGIVSVAESGMKHRDDIQMMQEAGFDAVLIG
EGLLVSEELRQFSWG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=250, Percent_Identity=35.6, Blast_Score=142, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322638, Length=230, Percent_Identity=40, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_CHLP8 (B3QLY7)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998140.1
- GeneID:   6419432
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0518
- HOGENOM:   HBG540956
- OMA:   THDEREL
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28728; Mature: 28597

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLTRILETKAEEVAELKKQDPERRYHEACGDLPATRDFRSAITSLDGGINLIAEVKKA
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHC
SPSRGVLVEDFRPLDIAERYAEIGASAFSVLTDRQYFQGSPDYLKAITQKFSIPVLRKEF
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH
IIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELGLHALVETHDERELDTALEQ
HCCHHHHHHHHHCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GSTIVGVNNRDLKTFTVDLMTSVRLRQRMPDGIVSVAESGMKHRDDIQMMQEAGFDAVLI
CCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
GEGLLVSEELRQFSWG
CCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TYLTRILETKAEEVAELKKQDPERRYHEACGDLPATRDFRSAITSLDGGINLIAEVKKA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHC
SPSRGVLVEDFRPLDIAERYAEIGASAFSVLTDRQYFQGSPDYLKAITQKFSIPVLRKEF
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH
IIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELGLHALVETHDERELDTALEQ
HCCHHHHHHHHHCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GSTIVGVNNRDLKTFTVDLMTSVRLRQRMPDGIVSVAESGMKHRDDIQMMQEAGFDAVLI
CCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
GEGLLVSEELRQFSWG
CCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA