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The map label for this gene is lpxH [H]

Identifier: 193211920

GI number: 193211920

Start: 256511

End: 257242

Strand: Direct

Name: lpxH [H]

Synonym: Cpar_0246

Alternate gene names: 193211920

Gene position: 256511-257242 (Clockwise)

Preceding gene: 193211919

Following gene: 193211921

Centisome position: 11.21

GC content: 55.46

Gene sequence:

>732_bases
ATGTCCGGACTTTATTTCGTCAGCGATCTTCATCTCGGCCTGCAAGAGTCGCATGCCGAGGCGGAGAAGCTCGAACGACT
CGAAACGCTTTTCTCCATCATCGCCGATAACGGTGGCTCGCTTTTCCTGCTTGGCGACATTCTCGACTACTGGATGGAGT
TCCGCCATGTCATTCCCAAAGGGTTCACCCGTTTTTTCTGCATGCTTTCCGGGCTGGTGCGCAGCGGAGTGCCGGTGACC
TGGCTTGCCGGGAATCATGACTTCTACCTCGGGAGCTTTTTTGACGATGAGCTGGGCGTGCGCACGCTGTACGGCATCCA
CGAGGTGCAGCACGACGGTCGTACTTTTCTTATGGCGCATGGCGACGGGCTGGGCGAGGGTGATACCGGCTACAAGCTGT
TCGCGCGCTTTGTCCGGAACCGTTTCAATCTCGGCTTGCTGACCGGCTTCCATTCCGATCTTTCGACCGCCCTGATGCGG
TGGTTTTCCCGTCTCAGCCGCAAGCATAAAAAGAGCGACATGCGCGTCGAATCGACACGATTGATCGATTTTGCCACTTC
GTTGGCTATGGAGCGCGATTTTGATTATTTTGTGTGCGGTCATAACCATGCGGAGCGTATCCAGAGCGTCCACGAGTCGG
ATAGCACTTATGTCAATCTTGGCTCCTGGATCGAGGGGCGCTATCAGTACGGCGTTTATGAGCAGGGAGAGTTCCGGCTC
ATCAAGCTCTAA

Upstream 100 bases:

>100_bases
GTGGAGGGGGCAAGCCCGAAAGAGGTGGACAACATCCTCATCCCTGTAACGGTGATTGCGCTCTCCCTGGCGCTTTTCTC
CTGAACCGCCTTTTCGATTA

Downstream 100 bases:

>100_bases
GTCAATCAATCATTTTTCACGTATCATGAGCAACAGCAACAACGTTCTTAAGCTGGGCCTGCCCAAAGGCAGTCTCCAGG
ACTCAACTCTCGAACTTTTC

Product: metallophosphoesterase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSGLYFVSDLHLGLQESHAEAEKLERLETLFSIIADNGGSLFLLGDILDYWMEFRHVIPKGFTRFFCMLSGLVRSGVPVT
WLAGNHDFYLGSFFDDELGVRTLYGIHEVQHDGRTFLMAHGDGLGEGDTGYKLFARFVRNRFNLGLLTGFHSDLSTALMR
WFSRLSRKHKKSDMRVESTRLIDFATSLAMERDFDYFVCGHNHAERIQSVHESDSTYVNLGSWIEGRYQYGVYEQGEFRL
IKL

Sequences:

>Translated_243_residues
MSGLYFVSDLHLGLQESHAEAEKLERLETLFSIIADNGGSLFLLGDILDYWMEFRHVIPKGFTRFFCMLSGLVRSGVPVT
WLAGNHDFYLGSFFDDELGVRTLYGIHEVQHDGRTFLMAHGDGLGEGDTGYKLFARFVRNRFNLGLLTGFHSDLSTALMR
WFSRLSRKHKKSDMRVESTRLIDFATSLAMERDFDYFVCGHNHAERIQSVHESDSTYVNLGSWIEGRYQYGVYEQGEFRL
IKL
>Mature_242_residues
SGLYFVSDLHLGLQESHAEAEKLERLETLFSIIADNGGSLFLLGDILDYWMEFRHVIPKGFTRFFCMLSGLVRSGVPVTW
LAGNHDFYLGSFFDDELGVRTLYGIHEVQHDGRTFLMAHGDGLGEGDTGYKLFARFVRNRFNLGLLTGFHSDLSTALMRW
FSRLSRKHKKSDMRVESTRLIDFATSLAMERDFDYFVCGHNHAERIQSVHESDSTYVNLGSWIEGRYQYGVYEQGEFRLI
KL

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=224, Percent_Identity=26.3392857142857, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010138 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 27963; Mature: 27832

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLYFVSDLHLGLQESHAEAEKLERLETLFSIIADNGGSLFLLGDILDYWMEFRHVIPK
CCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
GFTRFFCMLSGLVRSGVPVTWLAGNHDFYLGSFFDDELGVRTLYGIHEVQHDGRTFLMAH
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEE
GDGLGEGDTGYKLFARFVRNRFNLGLLTGFHSDLSTALMRWFSRLSRKHKKSDMRVESTR
CCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LIDFATSLAMERDFDYFVCGHNHAERIQSVHESDSTYVNLGSWIEGRYQYGVYEQGEFRL
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEECCCCCCCCEEECCEECCCEEE
IKL
EEC
>Mature Secondary Structure 
SGLYFVSDLHLGLQESHAEAEKLERLETLFSIIADNGGSLFLLGDILDYWMEFRHVIPK
CCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
GFTRFFCMLSGLVRSGVPVTWLAGNHDFYLGSFFDDELGVRTLYGIHEVQHDGRTFLMAH
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEE
GDGLGEGDTGYKLFARFVRNRFNLGLLTGFHSDLSTALMRWFSRLSRKHKKSDMRVESTR
CCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LIDFATSLAMERDFDYFVCGHNHAERIQSVHESDSTYVNLGSWIEGRYQYGVYEQGEFRL
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEECCCCCCCCEEECCEECCCEEE
IKL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA