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The map label for this gene is hisG

Identifier: 193211921

GI number: 193211921

Start: 257268

End: 258152

Strand: Direct

Name: hisG

Synonym: Cpar_0247

Alternate gene names: 193211921

Gene position: 257268-258152 (Clockwise)

Preceding gene: 193211920

Following gene: 193211922

Centisome position: 11.24

GC content: 56.05

Gene sequence:

>885_bases
ATGAGCAACAGCAACAACGTTCTTAAGCTGGGCCTGCCCAAAGGCAGTCTCCAGGACTCAACTCTCGAACTTTTCGCCAA
CGCCGGGTTTCATTTTTCCGTCCAGAGCCGTTCGTACTTTCCGTCCATCGACGACGATGAGCTGGAAGCGATTCTGATCC
GTGCCCAGGAGATGGCCCGCTACGTTTCGCAGGGTGCATTTGATGCCGGCTTGACTGGCAAGGACTGGATCATCGAAACC
GATGCCGATGTGGTCGAAGTGGCCGATCTGGTCTATTCCAAAGCTTCCATGCGCCCGGTACGCTGGGTACTTGCCGTGCC
TGAAAGCTCACCGATCCAGTCAGTCAGGGATCTCGAAGGCAAGCACATCGCCACTGAAGTGGTGAACATCACCAAAAAAT
ATCTGGCCAGGAATGGCGTGAACGCATCGGTCGAGTTCAGCTGGGGCGCGACTGAGGTTAAGCCGCCGGAGCTGGCCGAC
GCGATTGTCGAGGTGACCGAGACCGGCTCTTCGCTGCGCGCCAACAAGCTTCGTATCGTCGAGACGATTCTCGAATCCAA
CACCAAGCTCATCGCCAACAAGGCTTCGTGGGAAAACCCGTGGAAGCGCGAGAAGATCGAAAATATGGCCATGCTGCTTC
AGGGTGCGATCAACGCCCAGGGCAAGGTCGGCCTCAAGATGAACGCACCGAAAGCCGGGCTCAACAAGCTTATCGAGAGC
ATTCCGGCTCTGCGTCAGCCGACTATTTCCGATCTGGCTGACAACGCATGGGTTGCGATCGAAGTGATCGTTGACGAGAA
AGTCGTGCGCCACCTGATTCCCGATCTCAAGCGTGCTGGCGCCGAGGGTATTTTCGAGTACGACATCAACAAACTGATCG
ATTGA

Upstream 100 bases:

>100_bases
CTTGGCTCCTGGATCGAGGGGCGCTATCAGTACGGCGTTTATGAGCAGGGAGAGTTCCGGCTCATCAAGCTCTAAGTCAA
TCAATCATTTTTCACGTATC

Downstream 100 bases:

>100_bases
TTTCGATTCTGGGGTTTCAGGGGCAAGGAGAAGTACAACACTAAAGAACGTTTAAGCCTGTTCACGCCTTTAAGTCACCT
GACCATTTACGTAACTGTTA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSNSNNVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMARYVSQGAFDAGLTGKDWIIET
DADVVEVADLVYSKASMRPVRWVLAVPESSPIQSVRDLEGKHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPELAD
AIVEVTETGSSLRANKLRIVETILESNTKLIANKASWENPWKREKIENMAMLLQGAINAQGKVGLKMNAPKAGLNKLIES
IPALRQPTISDLADNAWVAIEVIVDEKVVRHLIPDLKRAGAEGIFEYDINKLID

Sequences:

>Translated_294_residues
MSNSNNVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMARYVSQGAFDAGLTGKDWIIET
DADVVEVADLVYSKASMRPVRWVLAVPESSPIQSVRDLEGKHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPELAD
AIVEVTETGSSLRANKLRIVETILESNTKLIANKASWENPWKREKIENMAMLLQGAINAQGKVGLKMNAPKAGLNKLIES
IPALRQPTISDLADNAWVAIEVIVDEKVVRHLIPDLKRAGAEGIFEYDINKLID
>Mature_293_residues
SNSNNVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMARYVSQGAFDAGLTGKDWIIETD
ADVVEVADLVYSKASMRPVRWVLAVPESSPIQSVRDLEGKHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPELADA
IVEVTETGSSLRANKLRIVETILESNTKLIANKASWENPWKREKIENMAMLLQGAINAQGKVGLKMNAPKAGLNKLIESI
PALRQPTISDLADNAWVAIEVIVDEKVVRHLIPDLKRAGAEGIFEYDINKLID

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=297, Percent_Identity=27.6094276094276, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320896, Length=285, Percent_Identity=27.0175438596491, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CHLP8 (B3QR09)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001997874.1
- GeneID:   6419160
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0247
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32353; Mature: 32222

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSNNVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMAR
CCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
YVSQGAFDAGLTGKDWIIETDADVVEVADLVYSKASMRPVRWVLAVPESSPIQSVRDLEG
HHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCC
KHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPELADAIVEVTETGSSLRANKLRIV
CHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
ETILESNTKLIANKASWENPWKREKIENMAMLLQGAINAQGKVGLKMNAPKAGLNKLIES
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IPALRQPTISDLADNAWVAIEVIVDEKVVRHLIPDLKRAGAEGIFEYDINKLID
HHHHCCCCHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SNSNNVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMAR
CCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
YVSQGAFDAGLTGKDWIIETDADVVEVADLVYSKASMRPVRWVLAVPESSPIQSVRDLEG
HHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCC
KHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPELADAIVEVTETGSSLRANKLRIV
CHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
ETILESNTKLIANKASWENPWKREKIENMAMLLQGAINAQGKVGLKMNAPKAGLNKLIES
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IPALRQPTISDLADNAWVAIEVIVDEKVVRHLIPDLKRAGAEGIFEYDINKLID
HHHHCCCCHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA