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The map label for this gene is hemN [H]

Identifier: 193211903

GI number: 193211903

Start: 236769

End: 237896

Strand: Direct

Name: hemN [H]

Synonym: Cpar_0229

Alternate gene names: 193211903

Gene position: 236769-237896 (Clockwise)

Preceding gene: 193211902

Following gene: 193211904

Centisome position: 10.34

GC content: 62.06

Gene sequence:

>1128_bases
ATGTTCAGCCTCTACGTTCACATCCCCTTCTGCCGTGAGCGTTGCCCTTACTGCGATTTTTTTCTGATTACCCGCCCCGG
TTTTGTCGAGCGCTTTTTCGAGGCGCTTGCCGTCGAGACCGCATCAAAGGCTTCGTTGCTTGAGGGGCGGACGATCGACG
CGATCCACTTTGGTGGCGGTACGCCGTCGCTGGTGCCGGTTTCGTTCATTTCCGGATGGCTGGAGCAGGTTGCCGGGCTG
GCCGGCCTGTCGGCTGATACCGAGATCACGCTTGAAGCCAATCCCGAAGACCTTGACACGGCGACGCTCGATGCGCTGCG
AGCGGCGGGCGTCAACCGCCTGAGTATCGGCGTGCAGTCGTTTACTGATCGCAAGCTCCGTGCGCTCGGCAGGGCGCACA
CGGCAGCGGATGCCGAGCGCACGGTGTCGGAGGCGTTGGAGCGCTTCCCGTCGGTGAGCATCGACCTGATCTGCGGGGCG
GAGGGGGAGAGCGCCAGGGAGTGGGAGGGCGATCTCCGTGCGGCGCTCCGGTTTCGTCCGCAGCACGTTTCGGTTTACAT
GCTCACTCTCGAAGAGAAGACCCGGCTTTGGCGTGATGTCAGCAAGGGACTCCGGGAGCTGCCCGGCGAGGGGCAACAGG
CTTCGATGTACCGGCAGGCCATGATGATGCTGTGCGGCGCGGGGTACCGGCACTACGAAGTTTCCAACTACGCGCTCGAA
GGGCACCATTCGCGTTACAACCTTTCAAGCTGGAAGCGCGAGCCGTACCTCGGTTTTGGGCCCTCGGCGCACAGCTTTCT
CCAAACGGCGGAGGGCGAGGTGCGCTTTTCCAACGCATCGAATCTGCATCGCTATCTCACCGATCCGGCCAACGCCACCG
ACTTCAGGGAGGTGCTTACCGCCGGGCAGCGGTTTGACGAGGAGGTGTTTCTTTCCCTGAGAATCCGCAAGGGGCTGACC
GTGGAGTTTTTGCGAAAAGGTCATACATTAGGGCTTCAGCGTCTGGATGACCGCCTTGCCCGGTTGCAGGCCGAAGGGTG
GATCGCGGTCGAGGGCGGACAGGTTACTCTGACCGATGATGGGTTCCTGTTTGCCGATCTCGTGGCCGGTGAGCTGCTGT
CGGAGTGA

Upstream 100 bases:

>100_bases
GTTTCCCGACCACGTAGCCGATGACCTCTACCAGGCCGTAACCGGGTATATTCTCGGCGAGCCGTCTCGCTGATTGCGCA
GGCGAATCAAAGTTTCCCCC

Downstream 100 bases:

>100_bases
CGGCATCATCCGGCATCCGAAACCGAAGCAAAGCGTTTTCAAGCACCAAACATGTCTCATAACAAGCTGAACAGGCTCAT
CGCCGTCCTCATCTTTGTCG

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MFSLYVHIPFCRERCPYCDFFLITRPGFVERFFEALAVETASKASLLEGRTIDAIHFGGGTPSLVPVSFISGWLEQVAGL
AGLSADTEITLEANPEDLDTATLDALRAAGVNRLSIGVQSFTDRKLRALGRAHTAADAERTVSEALERFPSVSIDLICGA
EGESAREWEGDLRAALRFRPQHVSVYMLTLEEKTRLWRDVSKGLRELPGEGQQASMYRQAMMMLCGAGYRHYEVSNYALE
GHHSRYNLSSWKREPYLGFGPSAHSFLQTAEGEVRFSNASNLHRYLTDPANATDFREVLTAGQRFDEEVFLSLRIRKGLT
VEFLRKGHTLGLQRLDDRLARLQAEGWIAVEGGQVTLTDDGFLFADLVAGELLSE

Sequences:

>Translated_375_residues
MFSLYVHIPFCRERCPYCDFFLITRPGFVERFFEALAVETASKASLLEGRTIDAIHFGGGTPSLVPVSFISGWLEQVAGL
AGLSADTEITLEANPEDLDTATLDALRAAGVNRLSIGVQSFTDRKLRALGRAHTAADAERTVSEALERFPSVSIDLICGA
EGESAREWEGDLRAALRFRPQHVSVYMLTLEEKTRLWRDVSKGLRELPGEGQQASMYRQAMMMLCGAGYRHYEVSNYALE
GHHSRYNLSSWKREPYLGFGPSAHSFLQTAEGEVRFSNASNLHRYLTDPANATDFREVLTAGQRFDEEVFLSLRIRKGLT
VEFLRKGHTLGLQRLDDRLARLQAEGWIAVEGGQVTLTDDGFLFADLVAGELLSE
>Mature_375_residues
MFSLYVHIPFCRERCPYCDFFLITRPGFVERFFEALAVETASKASLLEGRTIDAIHFGGGTPSLVPVSFISGWLEQVAGL
AGLSADTEITLEANPEDLDTATLDALRAAGVNRLSIGVQSFTDRKLRALGRAHTAADAERTVSEALERFPSVSIDLICGA
EGESAREWEGDLRAALRFRPQHVSVYMLTLEEKTRLWRDVSKGLRELPGEGQQASMYRQAMMMLCGAGYRHYEVSNYALE
GHHSRYNLSSWKREPYLGFGPSAHSFLQTAEGEVRFSNASNLHRYLTDPANATDFREVLTAGQRFDEEVFLSLRIRKGLT
VEFLRKGHTLGLQRLDDRLARLQAEGWIAVEGGQVTLTDDGFLFADLVAGELLSE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=284, Percent_Identity=40.8450704225352, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1789325, Length=278, Percent_Identity=36.6906474820144, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082341, Length=244, Percent_Identity=29.9180327868852, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41778; Mature: 41778

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01258 BH2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSLYVHIPFCRERCPYCDFFLITRPGFVERFFEALAVETASKASLLEGRTIDAIHFGGG
CEEEEEECCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
TPSLVPVSFISGWLEQVAGLAGLSADTEITLEANPEDLDTATLDALRAAGVNRLSIGVQS
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEECHHH
FTDRKLRALGRAHTAADAERTVSEALERFPSVSIDLICGAEGESAREWEGDLRAALRFRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCC
QHVSVYMLTLEEKTRLWRDVSKGLRELPGEGQQASMYRQAMMMLCGAGYRHYEVSNYALE
CEEEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCEEEC
GHHSRYNLSSWKREPYLGFGPSAHSFLQTAEGEVRFSNASNLHRYLTDPANATDFREVLT
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHCCCCEEECCCHHHHHHHCCCCCCHHHHHHHH
AGQRFDEEVFLSLRIRKGLTVEFLRKGHTLGLQRLDDRLARLQAEGWIAVEGGQVTLTDD
HHHCCCHHHEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEECC
GFLFADLVAGELLSE
CCCHHHHHHHHHHCC
>Mature Secondary Structure
MFSLYVHIPFCRERCPYCDFFLITRPGFVERFFEALAVETASKASLLEGRTIDAIHFGGG
CEEEEEECCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
TPSLVPVSFISGWLEQVAGLAGLSADTEITLEANPEDLDTATLDALRAAGVNRLSIGVQS
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEECHHH
FTDRKLRALGRAHTAADAERTVSEALERFPSVSIDLICGAEGESAREWEGDLRAALRFRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCC
QHVSVYMLTLEEKTRLWRDVSKGLRELPGEGQQASMYRQAMMMLCGAGYRHYEVSNYALE
CEEEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCEEEC
GHHSRYNLSSWKREPYLGFGPSAHSFLQTAEGEVRFSNASNLHRYLTDPANATDFREVLT
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHCCCCEEECCCHHHHHHHCCCCCCHHHHHHHH
AGQRFDEEVFLSLRIRKGLTVEFLRKGHTLGLQRLDDRLARLQAEGWIAVEGGQVTLTDD
HHHCCCHHHEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEECC
GFLFADLVAGELLSE
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]