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The map label for this gene is hmeD [H]

Identifier: 193211709

GI number: 193211709

Start: 39678

End: 41324

Strand: Direct

Name: hmeD [H]

Synonym: Cpar_0034

Alternate gene names: 193211709

Gene position: 39678-41324 (Clockwise)

Preceding gene: 193211708

Following gene: 193211710

Centisome position: 1.73

GC content: 58.59

Gene sequence:

>1647_bases
ATGTCCAAATACGCTCCAAAAACCGAAGAGCTCAAAAAAGAGTTCGAAGAGAAGAAGCCGCGGCTCCTGAAAGGGAAATT
CGACGGCATGGACTGGTGGGATATTCCGGTCGAGTTCCGCGACGGCAACTGGTGCTTCCCGGCCAAGCCGGAGGTGCTCG
AAGATCTCCACTTTCCCAATCCGAGGAAGTGGGCCGCCACCGACAAGGACTGGCAGCTTCCCGCCAACTGGGAAAAGACC
ATCCGCGACGGCATGAAGGATCGCCTTAAGCGGTTCCGCTCGTTCAAAGTGTTCATGGACAGCTGCGTGCGCTGCGGCGC
TTGCGCCGACAAGTGCCACTTCTTTCTCGGCACCGGTGACCCCAAGAACATGCCGGTGATGCGTGCCGAACTCGTCCGCT
CGATCTACCGCCAGGATGTGAACGCTTTTGCCCGTGTGCTGACCAAGTTCTCGGGATCGCGCAAGCTCACGCCGGAGGTG
ATCAAAGAGTGGCACATGTACTTCAACCAGTGCACCGAGTGCCGCCGCTGTTCGGTCTTCTGCCCGATGGGCATCGACAC
CGCCGAAATCACCATGATGGCCCGCGAGCTGCTCAATCTGATCGGCGTGAACAACAACTGGATTCTTGCGCCGGTGGCCA
ACTGCAACCGCACGGGCAACCACCTCGGTATCGAGCCTCACACTTTCAAGCAGAACATCATGTCGCTGGTCGATGACATC
GAGGATGTCACCGGCGTGAAGGTGAACCCGACCTTCAATCGCAAGGGGGCCGAAATCCTCTTCATTACGCCATCGGGCGA
CGTGTTCGGCGACCCCGGTGTCTATACGATGATGGGCTACCTGTTGTTGTTCCACCACATCGGCTTGGACTACACCATCA
GCACCTACGCTTCCGAGGGAGGCAACTTCGGTACCTTCACCTCGAACGAGATGATGAAGAAGCTGAACGCCAAGATGTAC
CACGAAGCCAAGCGGCTCGGGGTGAAATGGATTCTCGGCGGCGAGTGCGGGCACATGTGGCGCGTGGTGCATCAGTACAT
GAGCACGATGAACGGCCCGGCGGATTTCCTGCAGGAGCCGGTTTCGCCGATCACCGGCACGAAGTTCACCAACGCCAAAG
AGACCAAAATGGTGCACATCGCCGAGTTTACGGCCGATCTCATCAAGCACAACAAGCTGAAGCTCGATCCGAAGCGCAAC
GACCACCTGCGTACGACGTTCCACGATTCGTGCAACGTGGCGCGCGGCATGGGTATGTTCGAGGAGCCGCGTTACATCCT
GAACAAGGTGTGCAACACCTTCCACGAAATGCCCGAAAACACCATCCGCGAGCAGACCTTCTGCTGCGGCTCTGGCAGCG
GTCTGAACGCCGAGGAGTTCATGGACATCCGGATGCGCGGCGGCTTCCCGAGAGCCAACGCCGTAGCGCACGTCAAGGAG
AAGCACAAGGTCGATTCGCTGGTTACCATCTGCGCCATCGACCGCGCCAGCCTGACGCCGCTGATGCGCTACTGGAATCC
CGGTGTGTCGGTCTACGGCCTGCACGAGCTGGTGGGCAACGCGCTCATCATGGAGGGAGAGAAGAAACGAACCGAAGACC
TGAGGGAGGATGACATGGTTGGATTCGAGGAGGACGACGATGAATAA

Upstream 100 bases:

>100_bases
TGGAATCCCGACATCAAGTTCCGCTCCTATGCCGAATACGAGGATGAGTTCCGCGAGAAAATGAAAAAAGCTGGCATTCC
GGTCGATAAGCAATAACGAT

Downstream 100 bases:

>100_bases
AATCAGTCATATCCTCGGTGCTTTCGCTGCGGGCCTCGTCGTGTTCATCGCGGCCTGGTTCTTCATCCACGCTGGCCACG
GAGGCTCCATCCCGGCTCAC

Product: DsrK protein

Products: NA

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSKYAPKTEELKKEFEEKKPRLLKGKFDGMDWWDIPVEFRDGNWCFPAKPEVLEDLHFPNPRKWAATDKDWQLPANWEKT
IRDGMKDRLKRFRSFKVFMDSCVRCGACADKCHFFLGTGDPKNMPVMRAELVRSIYRQDVNAFARVLTKFSGSRKLTPEV
IKEWHMYFNQCTECRRCSVFCPMGIDTAEITMMARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFKQNIMSLVDDI
EDVTGVKVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGGNFGTFTSNEMMKKLNAKMY
HEAKRLGVKWILGGECGHMWRVVHQYMSTMNGPADFLQEPVSPITGTKFTNAKETKMVHIAEFTADLIKHNKLKLDPKRN
DHLRTTFHDSCNVARGMGMFEEPRYILNKVCNTFHEMPENTIREQTFCCGSGSGLNAEEFMDIRMRGGFPRANAVAHVKE
KHKVDSLVTICAIDRASLTPLMRYWNPGVSVYGLHELVGNALIMEGEKKRTEDLREDDMVGFEEDDDE

Sequences:

>Translated_548_residues
MSKYAPKTEELKKEFEEKKPRLLKGKFDGMDWWDIPVEFRDGNWCFPAKPEVLEDLHFPNPRKWAATDKDWQLPANWEKT
IRDGMKDRLKRFRSFKVFMDSCVRCGACADKCHFFLGTGDPKNMPVMRAELVRSIYRQDVNAFARVLTKFSGSRKLTPEV
IKEWHMYFNQCTECRRCSVFCPMGIDTAEITMMARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFKQNIMSLVDDI
EDVTGVKVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGGNFGTFTSNEMMKKLNAKMY
HEAKRLGVKWILGGECGHMWRVVHQYMSTMNGPADFLQEPVSPITGTKFTNAKETKMVHIAEFTADLIKHNKLKLDPKRN
DHLRTTFHDSCNVARGMGMFEEPRYILNKVCNTFHEMPENTIREQTFCCGSGSGLNAEEFMDIRMRGGFPRANAVAHVKE
KHKVDSLVTICAIDRASLTPLMRYWNPGVSVYGLHELVGNALIMEGEKKRTEDLREDDMVGFEEDDDE
>Mature_547_residues
SKYAPKTEELKKEFEEKKPRLLKGKFDGMDWWDIPVEFRDGNWCFPAKPEVLEDLHFPNPRKWAATDKDWQLPANWEKTI
RDGMKDRLKRFRSFKVFMDSCVRCGACADKCHFFLGTGDPKNMPVMRAELVRSIYRQDVNAFARVLTKFSGSRKLTPEVI
KEWHMYFNQCTECRRCSVFCPMGIDTAEITMMARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFKQNIMSLVDDIE
DVTGVKVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGGNFGTFTSNEMMKKLNAKMYH
EAKRLGVKWILGGECGHMWRVVHQYMSTMNGPADFLQEPVSPITGTKFTNAKETKMVHIAEFTADLIKHNKLKLDPKRND
HLRTTFHDSCNVARGMGMFEEPRYILNKVCNTFHEMPENTIREQTFCCGSGSGLNAEEFMDIRMRGGFPRANAVAHVKEK
HKVDSLVTICAIDRASLTPLMRYWNPGVSVYGLHELVGNALIMEGEKKRTEDLREDDMVGFEEDDDE

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 62805; Mature: 62674

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYAPKTEELKKEFEEKKPRLLKGKFDGMDWWDIPVEFRDGNWCFPAKPEVLEDLHFPN
CCCCCCCHHHHHHHHHHCCCCEECCCCCCCCEEECEEEECCCCCCCCCCHHHHHHCCCCC
PRKWAATDKDWQLPANWEKTIRDGMKDRLKRFRSFKVFMDSCVRCGACADKCHFFLGTGD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEECCC
PKNMPVMRAELVRSIYRQDVNAFARVLTKFSGSRKLTPEVIKEWHMYFNQCTECRRCSVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
CPMGIDTAEITMMARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFKQNIMSLVDDI
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EDVTGVKVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEG
HHHCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCC
GNFGTFTSNEMMKKLNAKMYHEAKRLGVKWILGGECGHMWRVVHQYMSTMNGPADFLQEP
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCC
VSPITGTKFTNAKETKMVHIAEFTADLIKHNKLKLDPKRNDHLRTTFHDSCNVARGMGMF
CCCCCCCCCCCCCHHHEEHHHHHHHHHHHCCCEEECCCCCCCCEEEHHCCCCHHHCCCCC
EEPRYILNKVCNTFHEMPENTIREQTFCCGSGSGLNAEEFMDIRMRGGFPRANAVAHVKE
CCCHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
KHKVDSLVTICAIDRASLTPLMRYWNPGVSVYGLHELVGNALIMEGEKKRTEDLREDDMV
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHHCCEEEECCCHHHHHHCCHHCCC
GFEEDDDE
CCCCCCCC
>Mature Secondary Structure 
SKYAPKTEELKKEFEEKKPRLLKGKFDGMDWWDIPVEFRDGNWCFPAKPEVLEDLHFPN
CCCCCCHHHHHHHHHHCCCCEECCCCCCCCEEECEEEECCCCCCCCCCHHHHHHCCCCC
PRKWAATDKDWQLPANWEKTIRDGMKDRLKRFRSFKVFMDSCVRCGACADKCHFFLGTGD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEECCC
PKNMPVMRAELVRSIYRQDVNAFARVLTKFSGSRKLTPEVIKEWHMYFNQCTECRRCSVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
CPMGIDTAEITMMARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFKQNIMSLVDDI
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EDVTGVKVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEG
HHHCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCC
GNFGTFTSNEMMKKLNAKMYHEAKRLGVKWILGGECGHMWRVVHQYMSTMNGPADFLQEP
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCC
VSPITGTKFTNAKETKMVHIAEFTADLIKHNKLKLDPKRNDHLRTTFHDSCNVARGMGMF
CCCCCCCCCCCCCHHHEEHHHHHHHHHHHCCCEEECCCCCCCCEEEHHCCCCHHHCCCCC
EEPRYILNKVCNTFHEMPENTIREQTFCCGSGSGLNAEEFMDIRMRGGFPRANAVAHVKE
CCCHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
KHKVDSLVTICAIDRASLTPLMRYWNPGVSVYGLHELVGNALIMEGEKKRTEDLREDDMV
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHHCCEEEECCCHHHHHHCCHHCCC
GFEEDDDE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA